55,874 research outputs found

    USING TRAJECTORIES FROM A BIVARIATEGROWTH CURVE OF COVARIATES IN A COXMODEL ANALYSIS

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    In many maintenance treatment trials, patients are first enrolled into an open treatmentbefore they are randomized into treatment groups. During this period, patients are followedover time with their responses measured longitudinally. This design is very common intoday's public health studies of the prevention of many diseases. Using mixed model theory, onecan characterize these data using a wide array of across subject models. A state-spacerepresentation of the mixed model and use of the Kalman filter allow more fexibility inchoosing the within error correlation structure even in the presence of missing and unequallyspaced observations. Furthermore, using the state-space approach, one can avoid invertinglarge matrices resulting in eficient computations. Estimated trajectories from these models can be used as predictors in a survival analysis in judging the efacacy of the maintenance treatments. The statistical problem lies in accounting for the estimation error in these predictors. We considered a bivariate growth curve where the longitudinal responses were unequally spaced and assumed that the within subject errors followed a continuous firstorder autoregressive (CAR (1)) structure. A simulation study was conducted to validatethe model. We developed a method where estimated random effects for each subject froma bivariate growth curve were used as predictors in the Cox proportional hazards model,using the full likelihood based on the conditional expectation of covariates to adjust for the estimation errors in the predictor variables. Simulation studies indicated that error corrected estimators for model parameters are mostly less biased when compared with thenave regression without accounting for estimation errors. These results hold true in Coxmodels with one or two predictors. An illustrative example is provided with data from a maintenance treatment trial for major depression in an elderly population. A Visual Fortran 90 and a SAS IML program are developed

    Limits for circular Jacobi beta-ensembles

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    Bourgade, Nikeghbali and Rouault recently proposed a matrix model for the circular Jacobi β\beta-ensemble, which is a generalization of the Dyson circular β\beta-ensemble but equipped with an additional parameter bb, and further studied its limiting spectral measure. We calculate the scaling limits for expected products of characteristic polynomials of circular Jacobi β\beta-ensembles. For the fixed constant bb, the resulting limit near the spectrum singularity is proven to be a new multivariate function. When b=βNd/2b=\beta Nd/2, the scaling limits in the bulk and at the soft edge agree with those of the Hermite (Gaussian), Laguerre (Chiral) and Jacobi β\beta-ensembles proved in the joint work with P Desrosiers "Asymptotics for products of characteristic polynomials in classical beta-ensembles", Constr. Approx. 39 (2014), arXiv:1112.1119v3. As corollaries, for even β\beta the scaling limits of point correlation functions for the ensemble are given. Besides, a transition from the spectrum singularity to the soft edge limit is observed as bb goes to infinity. The positivity of two special multivariate hypergeometric functions, which appear as one factor of the joint eigenvalue densities for spiked Jacobi/Wishart β\beta-ensembles and Gaussian β\beta-ensembles with source, will also be shown.Comment: 26 page

    Degree growth for tame automorphisms of an affine quadric threefold

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    In this paper, we consider the degree sequences of the tame automorphisms preserving an affine quadric threefold. Using some valuatives estimates derived from the work of Shestakov-Umirbaev and the action of this group on a CAT(0), Gromov-hyperbolic square complex constructed by Bisi-Furter-Lamy, we prove that the dynamical degrees of tame elements avoid any value strictly between 1 and 4/3. As an application, these methods allow us to characterize when the growth exponent of the degree of a random product of finitely many tame automorphisms is positive.Comment: This paper is part of the author's PhD thesi
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