Multicriteria Optimization in Water Resources Distribution Problem

A multicriteria problem on the distribution of water resources between four reservoirs with respect to electricity production in three countries is considered. The reservoirs are connected in a unique water system. The water inflow to one of the reservoirs is considered as the result of water releases from the others at previous time. The problem is to choose water releases which would provide maximum of the electricity in each country and minimum of fluctuations of the water levels in reservoirs as well. The multicriteria non-linear programming system DISO/PC-MCNLP is used for the solution of the problem

First results of the renewed Uragan-2M torsatron

The results of experimental investigation on the vacuum magnetic surfaces in the l=2 torsatron with an additional toroidal field Uragan-2M at wide varying operation parameters are presented. Also the first results on the wall conditioning in the Uragan-2M with the ECR and RF discharges in atmosphere of hydrogen in steady-state mode at low magnetic field, plasma production and heating with RF power are described.Представлено результати експериментального дослідження вакуумних магнітних поверхонь в l=2 торсатроні з додатковим магнітним полем Ураган-2М для широкої зміни операційних параметрів. Також описані перші результати підготовки першої стінки в Урагані-2М за допомогою ЕЦР і ВЧ розрядів в атмосфері водню в стаціонарному режимі при низькому магнітному полі, створення і нагріву плазми ВЧ потужністю.Представлены результаты экспериментального исследования вакуумных магнитных поверхностей в l=2 торсатроне с дополнительным магнитным полем Ураган-2М для широкого изменения операционных параметров. Также описаны первые результаты подготовки первой стенки в Урагане-2М при помощи ЭЦР и ВЧ разрядов в атмосфере водорода в стационарном режиме при низком магнитном поле, создания и нагрева плазмы ВЧ- мощностью

Micrometeorological simulations over a complex terrain with SUBMESCO: a model study using a novel pre-processor

International audienc

Synthesis of C-29-phosphonium derivatives of 3,28-diacetoxylup-20(29)-en-30-oic acid

© 2020, Springer Science+Business Media LLC. 3β,28-Diacetoxylup-20(29)-en-30-oic acid (obtained via oxidation of betulin diacetate) enters the addition reaction with P—H-phosphonium salts (triarylphosphonium trifluoroacetates) under mild conditions to afford β-carboxyalkylphosphonium salts. Structure and composition of the resulting compounds were confirmed by NMR and IR spectroscopy, mass spectrometry, and elemental analysis

3,28-Diacetoxylup-20(29)-ene-30-oic Acid and Its ω-Bromoalkyl Esters

© 2020, Pleiades Publishing, Ltd. Abstract: A convenient procedure has been developed for the synthesis of3β,28-diacetoxylup-20(29)-en-30-oic acid via oxidation of 3β,28-di-O-acetylbetulin with selenium dioxide in aqueousethanol on heating, followed by oxidation of 3β,28-diacetoxylup-20(29)-en-30-althus formed with sodium chlorite in tert-butyl alcohol. The alkylation of3β,28-diacetoxylup-20(29)-en-30-oic acid with 1,3-dibrompropane and1,5-dibromopentane in boiling acetonitrile in the presence of potassiumcarbonate afforded the corresponding ω-bromoalkyl esters in high yields

Turbulent Winds and Temperature Fronts in Large-Eddy Simulations of the Stable Atmospheric Boundary Layer

Geoscience and Remote SensingCivil Engineering and Geoscience

Synthesis and in vitro evaluation of triphenylphosphonium derivatives of acetylsalicylic and salicylic acids: structure-dependent interactions with cancer cells, bacteria, and mitochondria

Salicylic acid (SA) remains one of the most fruitful natural compounds to generate drug molecules with versatile activities. In this study, effective synthesis of SA and acetylsalicylic acid (ASA) derivatives with a carrier triphenylphoshonium (TPP) group was proposed. A series of SA and ASA conjugates linked with the TPP group via alkyl chain linker (C3-C10) was synthesized. The conjugates showed enhanced TPP-mediated cytotoxicity towards MCF-7, Caco-2, PC-3 cells in proportion to the linker length. 7e, 8e (C9), and 7f (C10) were the most active against the cancer cells with IC50 = 0.6–1.9 µM while were less toxic for HSF. Similarly, antibacterial (bactericidal) activity of the compounds against S. aureus increased with the linker elongation. The lowest MIC for SA and ASA derivatives were 4 and 1 µM, respectively. The TPP conjugates induced early linker length-dependent mitochondria depolarization and concurrent superoxide radical production in the cancer cells. The most lipophilic conjugates were found to specifically interact with ROS probe 2′,7′-dichlorofluorescin diacetate, forming mixed aggregates with the probe and inhibiting its fluorescence upon oxidation. These interactions were exploited to probe the compounds inside living cells. The results identify 7e and 7f as promising mitochondria-modulating and anticancer agents with increased cellular availability. [Figure not available: see fulltext.