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    The Physics of the B Factories

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    Placental transport of radionuclides. Terminal report, May 1, 1973--July 31, 1975. [Tritiated water, tritium, /sup 14/C, /sup 45/C, and /sup 47/C tracers]

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    Four successful experiments were conducted with tritiated water on pregnant sheep. This came into equilibrium between fetal and maternal circulations within 60 seconds after injection into the ewe or the fetus. The estimates of total water transport rate averaged 85% of the daily water intake. Six successful experiments were conducted with /sup 3/H- and /sup 14/C-glucose on pregnant ewes. The results for glucose space and transport rate in the ewes agree closely with previously published data. The fetal glucose pool size was large, presumably reflecting the relatively large volume of fetal-placental fluids in exchange with fetal blood. Six successful experiments were conducted with /sup 45/Ca and /sup 47/Ca for 5 days or more on pregnant ewes. The smallest compartment size of exchangeable calcium in mother and fetus were about 2 to 6 hours duration, and the net daily gain of calcium by the fetus was just slightly less in the chronic than in the acute experiments, 0.75 and 0.83 g/day respectively
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