A Study on the Parallelization of Terrain-Covering Ant Robots Simulations

Agent-based simulation is used as a tool for supporting (time-critical) decision making in differentiated contexts. Hence, techniques for speeding up the execution of agent-based models, such as Parallel Discrete Event Simulation (PDES), are of great relevance/benefit. On the other hand, parallelism entails that the final output provided by the simulator should closely match the one provided by a traditional sequential run. This is not obvious given that, for performance and efficiency reasons, parallel simulation engines do not allow the evaluation of global predicates on the simulation model evolution with arbitrary time-granularity along the simulation time-Axis. In this article we present a study on the effects of parallelization of agent-based simulations, focusing on complementary aspects such as performance and reliability of the provided simulation output. We target Terrain Covering Ant Robots (TCAR) simulations, which are useful in rescue scenarios to determine how many agents (i.e., robots) should be used to completely explore a certain terrain for possible victims within a given time. © 2014 Springer-Verlag Berlin Heidelberg

TIC 172900988: A transiting circumbinary planet detected in one sector of TESS data

We report the first discovery of a transiting circumbinary planet detected from a single sector of Transiting Exoplanet Survey Satellite (TESS) data. During Sector 21, the planet TIC 172900988b transited the primary star and then five days later it transited the secondary star. The binary is itself eclipsing, with a period P ≈ 19.7 days and an eccentricity e ≈ 0.45. Archival data from ASAS-SN, Evryscope, KELT, and SuperWASP reveal a prominent apsidal motion of the binary orbit, caused by the dynamical interactions between the binary and the planet. A comprehensive photodynamical analysis of the TESS, archival and follow-up data yields stellar masses and radii of M1 = 1.2384 ± 0.0007 Me and R1 = 1.3827 ± 0.0016 Re for the primary and M2 = 1.2019 ± 0.0007 Me and R2 = 1.3124 ± 0.0012 Re for the secondary. The radius of the planet is R3 = 11.25 ± 0.44 R (1.004 ± 0.039RJup). The planet's mass and orbital properties are not uniquely determined-there are six solutions with nearly equal likelihood. Specifically, we find that the planet's mass is in the range of 824 M3 981 M (2.65 M3 3.09MJup), its orbital period could be 188.8, 190.4, 194.0, 199.0, 200.4, or 204.1 days, and the eccentricity is between 0.02 and 0.09. At V = 10.141 mag, the system is accessible for high-resolution spectroscopic observations, e.g., the Rossiter-McLaughlin effect and transit spectroscopy

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

A TENTATIVE ESTIMATION OF MAN'S TOLERANCE TO OVERPRESSURES FROM AIR BLAST. Technical Progress Report

Tentative estimates of the sharp''-rising overpressures as a function of duration which represent a lethal hazard to the 70-kg animal 1, 50, and 99% of the time were presented. The predictions were based on interspecies correlations and extrapolations encompassing blast-tolerance data for six mammalian species. The tentative application of the data to indicate human blast tolerance was discussed and relevant uncertainties in the estimates were emphasized. It was also pointed out that biologic tolerance would be different for air-blast pulses having non-ideal wave forms frequently associated with various geometries of exposure. Selected pathophysiological information pertinent to the biological response following blast exposure was given; namely, survival time and selected postshot observations of dogs and goats. (auth