99 research outputs found

    Plant natriuretic peptide signalling processes

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    Self-Similar Scalar Field Collapse: Naked Singularities and Critical Behaviour

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    Homothetic scalar field collapse is considered in this article. By making a suitable choice of variables the equations are reduced to an autonomous system. Then using a combination of numerical and analytic techniques it is shown that there are two classes of solutions. The first consists of solutions with a non-singular origin in which the scalar field collapses and disperses again. There is a singularity at one point of these solutions, however it is not visible to observers at finite radius. The second class of solutions includes both black holes and naked singularities with a critical evolution (which is neither) interpolating between these two extremes. The properties of these solutions are discussed in detail. The paper also contains some speculation about the significance of self-similarity in recent numerical studies.Comment: 27 pages including 5 encapsulated postcript figures in separate compressed file, report NCL94-TP1

    Higher dimensional dust collapse with a cosmological constant

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    The general solution of the Einstein equation for higher dimensional (HD) spherically symmetric collapse of inhomogeneous dust in presence of a cosmological term, i.e., exact interior solutions of the Einstein field equations is presented for the HD Tolman-Bondi metrics imbedded in a de Sitter background. The solution is then matched to exterior HD Scwarschild-de Sitter. A brief discussion on the causal structure singularities and horizons is provided. It turns out that the collapse proceed in the same way as in the Minkowski background, i.e., the strong curvature naked singularities form and that the higher dimensions seem to favor black holes rather than naked singularities.Comment: 7 Pages, no figure

    Direct measurement of optical quasidistribution functions: multimode theory and homodyne tests of Bell's inequalities

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    We develop a multimode theory of direct homodyne measurements of quantum optical quasidistribution functions. We demonstrate that unbalanced homodyning with appropriately shaped auxiliary coherent fields allows one to sample point-by-point different phase space representations of the electromagnetic field. Our analysis includes practical factors that are likely to affect the outcome of a realistic experiment, such as non-unit detection efficiency, imperfect mode matching, and dark counts. We apply the developed theory to discuss feasibility of observing a loophole-free violation of Bell's inequalities by measuring joint two-mode quasidistribution functions under locality conditions by photon counting. We determine the range of parameters of the experimental setup that enable violation of Bell's inequalities for two states exhibiting entanglement in the Fock basis: a one-photon Fock state divided by a 50:50 beam splitter, and a two-mode squeezed vacuum state produced in the process of non-degenerate parametric down-conversion.Comment: 18 pages, 7 figure

    About Bianchi I with VSL

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    In this paper we study how to attack, through different techniques, a perfect fluid Bianchi I model with variable G,c and Lambda, but taking into account the effects of a cc-variable into the curvature tensor. We study the model under the assumption,div(T)=0. These tactics are: Lie groups method (LM), imposing a particular symmetry, self-similarity (SS), matter collineations (MC) and kinematical self-similarity (KSS). We compare both tactics since they are quite similar (symmetry principles). We arrive to the conclusion that the LM is too restrictive and brings us to get only the flat FRW solution. The SS, MC and KSS approaches bring us to obtain all the quantities depending on \int c(t)dt. Therefore, in order to study their behavior we impose some physical restrictions like for example the condition q<0 (accelerating universe). In this way we find that cc is a growing time function and Lambda is a decreasing time function whose sing depends on the equation of state, w, while the exponents of the scale factor must satisfy the conditions ∑i=13αi=1\sum_{i=1}^{3}\alpha_{i}=1 and ∑i=13αi2<1,\sum_{i=1}^{3}\alpha_{i}^{2}<1, ∀ω\forall\omega, i.e. for all equation of state,, relaxing in this way the Kasner conditions. The behavior of GG depends on two parameters, the equation of state ω\omega and Ï”,\epsilon, a parameter that controls the behavior of c(t),c(t), therefore GG may be growing or decreasing.We also show that through the Lie method, there is no difference between to study the field equations under the assumption of a c−c-var affecting to the curvature tensor which the other one where it is not considered such effects.Nevertheless, it is essential to consider such effects in the cases studied under the SS, MC, and KSS hypotheses.Comment: 29 pages, Revtex4, Accepted for publication in Astrophysics & Space Scienc

    The Similarity Hypothesis in General Relativity

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    Self-similar models are important in general relativity and other fundamental theories. In this paper we shall discuss the ``similarity hypothesis'', which asserts that under a variety of physical circumstances solutions of these theories will naturally evolve to a self-similar form. We will find there is good evidence for this in the context of both spatially homogenous and inhomogeneous cosmological models, although in some cases the self-similar model is only an intermediate attractor. There are also a wide variety of situations, including critical pheneomena, in which spherically symmetric models tend towards self-similarity. However, this does not happen in all cases and it is it is important to understand the prerequisites for the conjecture.Comment: to be submitted to Gen. Rel. Gra

    Gaussian quantum operator representation for bosons

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    We introduce a Gaussian quantum operator representation, using the most general possible multimode Gaussian operator basis. The representation unifies and substantially extends existing phase-space representations of density matrices for Bose systems and also includes generalized squeezed-state and thermal bases. It enables first-principles dynamical or equilibrium calculations in quantum many-body systems, with quantum uncertainties appearing as dynamical objects. Any quadratic Liouville equation for the density operator results in a purely deterministic time evolution. Any cubic or quartic master equation can be treated using stochastic methods

    Bianchi II with time varying constants. Self-similar approach

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    We study a perfect fluid Bianchi II models with time varying constants under the self-similarity approach. In the first of the studied model, we consider that only vary GG and Λ.\Lambda. The obtained solution is more general that the obtained one for the classical solution since it is valid for an equation of state ω∈(−1,∞)\omega\in(-1,\infty) while in the classical solution ω∈(−1/3,1).\omega\in(-1/3,1) . Taking into account the current observations, we conclude that GG must be a growing time function while Λ\Lambda is a positive decreasing function. In the second of the studied models we consider a variable speed of light (VSL). We obtain a similar solution as in the first model arriving to the conclusions that cc must be a growing time function if Λ\Lambda is a positive decreasing function.Comment: 10 pages. RevTeX

    The Public Repository of Xenografts enables discovery and randomized phase II-like trials in mice

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    More than 90% of drugs with preclinical activity fail in human trials, largely due to insufficient efficacy. We hypothesized that adequately powered trials of patient-derived xenografts (PDX) in mice could efficiently define therapeutic activity across heterogeneous tumors. To address this hypothesis, we established a large, publicly available repository of well-characterized leukemia and lymphoma PDXs that undergo orthotopic engraftment, called the Public Repository of Xenografts (PRoXe). PRoXe includes all de-identified information relevant to the primary specimens and the PDXs derived from them. Using this repository, we demonstrate that large studies of acute leukemia PDXs that mimic human randomized clinical trials can characterize drug efficacy and generate transcriptional, functional, and proteomic biomarkers in both treatment-naive and relapsed/refractory disease
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