10 research outputs found

    Pineal serotonin is resistant to depletion by serotonergic neurotoxins in rats

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    : Administration of 3,4‐methylenedioxymethamphetamine (MDMA) or para‐chloroamphetamine (pCA) to adult rats is neurotoxic to serotonin (5HT) nerve terminals and cell bodies. MDMA (10 mg/kg) reduces; 5HT levels in the frontal cortex, medial basal hypothalamus, and striatum acutely and 17 days after a series of multiple injections. The acute reductions occur within 1–2 hr after injection of doses greater than 3 mg/kg. A single injection of pCA reduces 5HT levels in the above mentioned brain regions as well as in the brain stem. However, none of these treatments are able to alter 5HT levels in the pineal gland. It appears that the pineal does not contain the 5HT reuptake system that is thought to be necessary for the neurotoxicity of MDMA and pCA

    Experimental studies on 3,4-methylenedioxymethamphetamine (MDMA, “ECSTASY”) and its potential to damage brain serotonin neurons

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    Chapter One Current Challenges and Frameworks

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    The Role of Th2-Mediated Anti-Tumor Immunity in Tumor Surveillance and Clearance

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    Antiparkinsonian Treatment for Depression in Parkinson's Disease: Are Selective Serotonin Reuptake Inhibitors Recommended?

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    The Role of the Status of Selected Micronutrients in Shaping the Immune Function

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    Selective neurotoxins, chemical tools to probe the mind: The first Thirty years and beyond

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    Bibliography

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    Neurochemistry of Drug Abuse

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