228 research outputs found
Active vibration control (AVC) of a satellite boom structure using optimally positioned stacked piezoelectric actuators
In this paper, results for active vibration control predicted from experimental measurements on a lightweight structure are compared with purely computational predictions. The structure studied is a 4.5m long satellite boom consisting of 10 identical bays with equilateral triangular cross sections. First, the results from a Fortran code that is based on a receptance analysis are validated against the experimental forced response of the boom structure. Exhaustive searches are then carried out to find the optimum positions for one and two actuators. Finally, a genetic algorithm is employed to find high-quality positions for three actuators on the structure that will achieve the greatest reductions in vibration transmission. Having found these actuator positions, experiments are then carried out to verify the quality of the theoretical predictions. It was found that the attenuation achievable in practice for one, two and three actuators were, respectively, 15.1, 26.1 and 33.5 dB
Active vibration control (AVC) of a satellite boom structure using optimally positioned stacked piezoelectric actuators
In this paper, results for active vibration control predicted from experimental measurements on a lightweight structure are compared with purely computational predictions. The structure studied is a 4.5m long satellite boom consisting of 10 identical bays with equilateral triangular cross sections. First, the results from a Fortran code that is based on a receptance analysis are validated against the experimental forced response of the boom structure. Exhaustive searches are then carried out to find the optimum positions for one and two actuators. Finally, a genetic algorithm is employed to find high-quality positions for three actuators on the structure that will achieve the greatest reductions in vibration transmission. Having found these actuator positions, experiments are then carried out to verify the quality of the theoretical predictions. It was found that the attenuation achievable in practice for one, two and three actuators were, respectively, 15.1, 26.1 and 33.5 dB
Determination of polarized parton distribution functions and their uncertainties
We investigate the polarized parton distribution functions (PDFs) and their
uncertainties by using the world data on the spin asymmetry A_1. The
uncertainties of the polarized PDFs are estimated by the Hessian method. The up
and down valence-quark distributions are determined well. However, the
antiquark distributions have large uncertainties at this stage, and it is
particularly difficult to fix the gluon distribution. The \chi^2 analysis
produces a positively polarized gluon distribution, but even \Delta g(x)=0
could be allowed according to our uncertainty estimation. In comparison with
the previous AAC (Asymmetry Analysis Collaboration) parameterization in 2000,
accurate SLAC-E155 proton data are added to the analysis. We find that the E155
data improve the determination of the polarized PDFs, especially the polarized
antiquark distributions. In addition, the gluon-distribution uncertainties are
reduced due to the correlation with the antiquark distributions. We also show
the global analysis results with the condition \Delta g(x)=0 at the initial
scale, Q^2=1 GeV^2, for clarifying the error correlation effects with the gluon
distribution.Comment: 9 pages, 15 eps figures, REVTeX, FORTRAN package is available at the
web site http://www-hs.phys.saga-u.ac.jp/aac.html. Replaced 3 eps figures in
Fig.
Sensitisation of cancer cells to radiotherapy by serine and glycine starvation
Background:
Cellular metabolism is an integral component of cellular adaptation to stress, playing a pivotal role in the resistance of cancer cells to various treatment modalities, including radiotherapy. In response to radiotherapy, cancer cells engage antioxidant and DNA repair mechanisms which mitigate and remove DNA damage, facilitating cancer cell survival. Given the reliance of these resistance mechanisms on amino acid metabolism, we hypothesised that controlling the exogenous availability of the non-essential amino acids serine and glycine would radiosensitise cancer cells.
Methods:
We exposed colorectal, breast and pancreatic cancer cell lines/organoids to radiation in vitro and in vivo in the presence and absence of exogenous serine and glycine. We performed phenotypic assays for DNA damage, cell cycle, ROS levels and cell death, combined with a high-resolution untargeted LCMS metabolomics and RNA-Seq.
Results:
Serine and glycine restriction sensitised a range of cancer cell lines, patient-derived organoids and syngeneic mouse tumour models to radiotherapy. Comprehensive metabolomic and transcriptomic analysis of central carbon metabolism revealed that amino acid restriction impacted not only antioxidant response and nucleotide synthesis but had a marked inhibitory effect on the TCA cycle.
Conclusion:
Dietary restriction of serine and glycine is a viable radio-sensitisation strategy in cancer
- …