58 research outputs found

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    Imported quartz cement in aeolian sandstone grew from water of uniform composition but has complex zonation

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    The origins and volumes of waters which mass-transport silica in sedimentary basins remain obscure. Many previous analytical studies have illustrated cases where quartz cements in sandstones originate from complex and variable fluids. By contrast we show, by using a combination of separation and analytical techniques, that in Lower Permian sandstones of the southern North Sea the cementing fluid was isotopically uniform during growth of quartz cement with a δ1BO of 19.6 + 1.0%‰ V-SMOW. In this relatively uniform fluid quartz cements grew and developed complex cathodoluminescence (CL) zonations. Petrographic data show that 8–10% quartz cement (locally 30%) was imported into this 380 km2× 180 m thick aeolian sandstone, and cement distribution controlled by depositional permeabilities. We infer a large-scale, high volume, flux of evolved meteoric fluid during 2 km deep burial, and show that complex CL zonation may arise from relatively subtle changes in water composition

    Defining the origin of Plasmodium falciparum resistant dhfr isolates in Senegal.

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    We previously reported a high baseline prevalence of mutations in the dhfr and dhps genes of Plasmodium falciparum throughout Senegal. The highest prevalence of the triple dhfr pyrimethamine associated mutations were found in isolates obtained in the western part of the country near the capital city of Dakar. In this study, we sought out to determine the relatedness of dhfr wild type and mutated strains by analyzing three microsatellite regions upstream of the dhfr locus. Twenty-six of the 31 wild type strains had a unique microsatellite pattern. In contrast, of the 17 isolates containing the triple mutation in dhfr, 11 had an identical microsatellite pattern. Diverse geographical isolates in Senegal containing the triple dhfr mutation have arisen from a limited number of ancestral strains. In addition, we demonstrate that these isolates have shared ancestry with the previously reported triple mutation haplotype found in Tanzania, South Africa, and southeast Asia. This common ancestry may have implications for the malaria control strategy for reducing the spread of sulfadoxine-pyrimethamine resistance in Senegal and elsewhere in Africa
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