291 research outputs found
Energy Release During Slow Long Duration Flares Observed by RHESSI
Slow Long Duration Events (SLDEs) are flares characterized by long duration
of rising phase. In many such cases impulsive phase is weak with lack of
typical short-lasting pulses. Instead of that smooth, long-lasting Hard X-ray
(HXR) emission is observed. We analysed hard X-ray emission and morphology of
six selected SLDEs. In our analysis we utilized data from RHESSI and GOES
satellites. Physical parameters of HXR sources were obtained from imaging
spectroscopy and were used for the energy balance analysis. Characteristic time
of heating rate decrease, after reaching its maximum value, is very long, which
explains long rising phase of these flares.Comment: Accepted for publication in Solar Physic
Svestka's Research: Then and Now
Zdenek Svestka's research work influenced many fields of solar physics,
especially in the area of flare research. In this article I take five of the
areas that particularly interested him and assess them in a "then and now"
style. His insights in each case were quite sound, although of course in the
modern era we have learned things that he could not readily have envisioned.
His own views about his research life have been published recently in this
journal, to which he contributed so much, and his memoir contains much
additional scientific and personal information (Svestka, 2010).Comment: Invited review for "Solar and Stellar Flares," a conference in honour
of Prof. Zden\v{e}k \v{S}vestka, Prague, June 23-27, 2014. This is a
contribution to a Topical Issue in Solar Physics, based on the presentations
at this meeting (Editors Lyndsay Fletcher and Petr Heinzel
Density of states in d-wave superconductors disordered by extended impurities
The low-energy quasiparticle states of a disordered d-wave superconductor are
investigated theoretically. A class of such states, formed via tunneling
between the Andreev bound states that are localized around extended impurities
(and result from scattering between pair-potential lobes that differ in sign)
is identified. Its (divergent) contribution to the total density of states is
determined by taking advantage of connections with certain one-dimensional
random tight-binding models. The states under discussion should be
distinguished from those associated with nodes in the pair potential.Comment: 5 pages, 1 figur
Impurity and interface bound states in and superconductors
Motivated by recent discoveries of novel superconductors such as
NaCoOHO and SrRuO, we analysize features of
quasi-particle scattering due to impurities and interfaces for possible gapful
and Cooper pairing. A bound state appears near
a local impurity, and a band of bound states form near an interface. We
obtained analytically the bound state energy, and calculated the space and
energy dependent local density of states resolvable by high-resolution scanning
tunnelling microscopy. For comparison we also sketch results of impurity and
surface states if the pairing is nodal p- or d-wave.Comment: 4 pages, 4 figure
Peak grain forecasts for the US High Plains amid withering waters
ACKNOWLEDGMENTS. This paper stems from discussions during the Ettersburg Ecohydrology Workshop in Germany (October 2018), with the corresponding manuscript preparation ensuing in subsequent months. The workshop was funded by the UNIDEL Foundation, Inc. and the University of Delaware. Accordingly, partial support for this paper derived from funding for the workshop. A.M. was supported by the US NSF (Grants NSF-AGS-1644382 and NSF-IOS-175489).Peer reviewedPublisher PD
On the Nature and Genesis of EUV Waves: A Synthesis of Observations from SOHO, STEREO, SDO, and Hinode
A major, albeit serendipitous, discovery of the SOlar and Heliospheric
Observatory mission was the observation by the Extreme Ultraviolet Telescope
(EIT) of large-scale Extreme Ultraviolet (EUV) intensity fronts propagating
over a significant fraction of the Sun's surface. These so-called EIT or EUV
waves are associated with eruptive phenomena and have been studied intensely.
However, their wave nature has been challenged by non-wave (or pseudo-wave)
interpretations and the subject remains under debate. A string of recent solar
missions has provided a wealth of detailed EUV observations of these waves
bringing us closer to resolving their nature. With this review, we gather the
current state-of-art knowledge in the field and synthesize it into a picture of
an EUV wave driven by the lateral expansion of the CME. This picture can
account for both wave and pseudo-wave interpretations of the observations, thus
resolving the controversy over the nature of EUV waves to a large degree but
not completely. We close with a discussion of several remaining open questions
in the field of EUV waves research.Comment: Solar Physics, Special Issue "The Sun in 360",2012, accepted for
publicatio
B7-H3-redirected chimeric antigen receptor T cells target glioblastoma and neurospheres
Background: The dismal survival of glioblastoma (GBM) patients urgently calls for the development of new treatments. Chimeric antigen receptor T (CAR-T) cells are an attractive strategy, but preclinical and clinical studies in GBM have shown that heterogeneous expression of the antigens targeted so far causes tumor escape, highlighting the need for the identification of new targets. We explored if B7-H3 is a valuable target for CAR-T cells in GBM. Methods: We compared mRNA expression of antigens in GBM using TCGA data, and validated B7-H3 expression by immunohistochemistry. We then tested the antitumor activity of B7-H3-redirected CAR-T cells against GBM cell lines and patient-derived GBM neurospheres in vitro and in xenograft murine models. Findings: B7-H3 mRNA and protein are overexpressed in GBM relative to normal brain in all GBM subtypes. Of the 46 specimens analyzed by immunohistochemistry, 76% showed high B7-H3 expression, 22% had detectable, but low B7-H3 expression and 2% were negative, as was normal brain. All 20 patient-derived neurospheres showed ubiquitous B7-H3 expression. B7-H3-redirected CAR-T cells effectively targeted GBM cell lines and neurospheres in vitro and in vivo. No significant differences were found between CD28 and 4-1BB co-stimulation, although CD28-co-stimulated CAR-T cells released more inflammatory cytokines. Interpretation: We demonstrated that B7-H3 is highly expressed in GBM specimens and neurospheres that contain putative cancer stem cells, and that B7-H3-redirected CAR-T cells can effectively control tumor growth. Therefore, B7-H3 represents a promising target in GBM. Fund: Alex's Lemonade Stand Foundation; Il Fondo di Gio Onlus; National Cancer Institute; Burroughs Wellcome Fund
Equations for the estimation of strong ground motions from shallow crustal earthquakes using data from Europe and the Middle East : vertical peak ground acceleration and spectral acceleration
This article presents equations for the estimation of vertical strong ground motions caused by shallow crustal earthquakes with magnitudes M w 5 and distance to the surface projection of the fault less than 100km. These equations were derived by weighted regression analysis, used to remove observed magnitude-dependent variance, on a set of 595 strong-motion records recorded in Europe and the Middle East. Coefficients are included to model the effect of local site effects and faulting mechanism on the observed ground motions. The equations include coefficients to model the observed magnitude-dependent decay rate. The main findings of this study are that: short-period ground motions from small and moderate magnitude earthquakes decay faster than the commonly assumed 1/r, the average effect of differing faulting mechanisms is similar to that observed for horizontal motions and is not large and corresponds to factors between 0.7 (normal and odd) and 1.4 (thrust) with respect to strike-slip motions and that the average long-period amplification caused by soft soil deposits is about 2.1 over those on rock sites
An Observational Overview of Solar Flares
We present an overview of solar flares and associated phenomena, drawing upon
a wide range of observational data primarily from the RHESSI era. Following an
introductory discussion and overview of the status of observational
capabilities, the article is split into topical sections which deal with
different areas of flare phenomena (footpoints and ribbons, coronal sources,
relationship to coronal mass ejections) and their interconnections. We also
discuss flare soft X-ray spectroscopy and the energetics of the process. The
emphasis is to describe the observations from multiple points of view, while
bearing in mind the models that link them to each other and to theory. The
present theoretical and observational understanding of solar flares is far from
complete, so we conclude with a brief discussion of models, and a list of
missing but important observations.Comment: This is an article for a monograph on the physics of solar flares,
inspired by RHESSI observations. The individual articles are to appear in
Space Science Reviews (2011
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