Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7×10-8, HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10-8, HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4×10-8, HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific associat

A perceptual adaptation account of preview effect in the Eriksen flanker task

This volume contains the invited lectures, invited symposia, symposia, papers and posters presented at the 2nd European Cognitive Science Conference held in Greece in May 2007. The papers presented in this volume range from empirical psychological studies and computational models to philosophical arguments, meta-analyses and even to neuroscientific experimentation. The quality of the work shows that the Cognitive Science Society in Europe is an exciting and vibrant one. There are 210 contributions by cognitive scientists from 27 different countries, including USA, France, UK, Germany, Greece, Italy, Belgium, Japan, Spain, the Netherlands, and Australia

Lithium as a Differential Neuroprotector During Brain Irradiation

info:eu-repo/semantics/publishe

An interference account of cue-independent forgetting in the no-think paradigm

Memory suppression is investigated with the no-think paradigm, which produces forgetting following repeated practice of not thinking about a memory [Anderson MC, Green C (2001) Nature 410:366–369]. Because the forgotten item is not retrieved even when tested with an independent, semantically related cue, it has been assumed that this forgetting is due to an inhibition process. However, this conclusion is based on a single stage to recall, whereas global memory models, which produce forgetting through a process of interference, include both a sampling and a recovery stage to recall. By assuming that interference exists during recovery, these models can explain cue-independent forgetting. We tested several predictions of this interference explanation of cue-independent forgetting by modifying the think/no-think paradigm. We added a condition where participants quickly pressed enter rather than not thinking. We also manipulated initial memory strength and tested recognition memory. Most importantly, learning to quickly press enter produced as much cue-independent forgetting as no-think instructions. Demonstrating the adequacy of two-stage recall, a simple computational model (SAM-RI) simultaneously captured the original cue, independent cue, and recognition results

Geologic Map of the east half of the Black Canyon City 7.5’ Quadrangle and the west half of the Squaw Creek Mesa 7.5’ Quadrangle, Maricopa County, Arizona v 1.0

The eastern Black Canyon City 7 ½' Quadrangle and the western Squaw Creek Mesa 7 ½' Quadrangle includes the Interstate 17 corridor where it passes through Black Canyon City and Rock Springs and continues north up the steep grade on the southwest slope of Black Mesa (Figure 1). The distribution of surfaces of different ages and sources in the Black Canyon City quadrangle is associated with the Agua Fria River and Quaternary landslides in the southern and northern halves of the quadrangle, respectively. The southern half of the quadrangle is dominated by the incised Agua Fria River and its tributaries (Little Squaw Creek and Moore Gulch). The Agua Fria River has incised up to 60 m into Paleoproterozoic bedrock (Xs) in the 11 southwestern quarter of the quadrangle. The Little Squaw Creek and Moore Gulch have incised up to 20 m into Chalk Canyon Formation (Tc, Tcl, Tcs) in the southern half of the quadrangle. The northern half of the quadrangle is dominated by Quaternary landslides (Figure 2, 3) ranging from relatively fresh Holocene landslides (Qylsd) to degraded Pleistocene landslides (Qlso). Several older landslide deposits contain younger landslides, indicating that younger mass-wasting events have occurred on older landslide deposits.Documents in the AZGS Documents Repository collection are made available by the Arizona Geological Survey (AZGS) and the University Libraries at the University of Arizona. For more information about items in this collection, please contact [email protected]