AN EFFICIENT ALGORITHM FORMINING HIGH UTILITY ASSOCIATION RULES FROM LATTICE

In business, most of companies focus on growing their profits. Besides considering profit from each product, they also focus on the relationship among products in order to support effective decision making, gain more profits and attract their customers, e.g. shelf arrangement, product displays, or product marketing, etc. Some high utility association rules have been proposed, however, they consume much memory and require long time processing. This paper proposes LHAR (Lattice-based for mining High utility Association Rules) algorithm to mine high utility association rules based on a lattice of high utility itemsets. The LHAR algorithm aims to generates high utility association rules during the process of building lattice of high utility itemsets, and thus it needs less memory and runtim

Removing critical gaps in chemical test methods by developing new assays for the identification of thyroid hormone system-disrupting chemicals—the athena project

The test methods that currently exist for the identification of thyroid hormone system-disrupting chemicals are woefully inadequate. There are currently no internationally validated in vitro assays, and test methods that can capture the consequences of diminished or enhanced thyroid hormone action on the developing brain are missing entirely. These gaps put the public at risk and risk assessors in a difficult position. Decisions about the status of chemicals as thyroid hormone system disruptors currently are based on inadequate toxicity data. The ATHENA project (Assays for the identification of Thyroid Hormone axis-disrupting chemicals: Elaborating Novel Assessment strategies) has been conceived to address these gaps. The project will develop new test methods for the disruption of thyroid hormone transport across biological barriers such as the blood–brain and blood–placenta barriers. It will also devise methods for the disruption of the downstream effects on the brain. ATHENA will deliver a testing strategy based on those elements of the thyroid hormone system that, when disrupted, could have the greatest impact on diminished or enhanced thyroid hormone action and therefore should be targeted through effective testing. To further enhance the impact of the ATHENA test method developments, the project will develop concepts for better international collaboration and development in the area of thyroid hormone system disruptor identification and regulation

Renal endoplasmic reticulum stress is coupled to impaired autophagy in a mouse model of GSD Ia

10.1016/j.ymgme.2017.08.013Molecular Genetics and Metabolism122395-9

Hepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa)

10.1038/srep44408Scientific Reports74440

Design and synthesis of key intermediates giving access to potentiators for the kainate subtype glutamate receptors.

Based on the major role played by glutamate in our brain, the glutamatergic receptors constitute interesting targets to develop therapeutic drugs. Amongst all the pharmacological classes that have been investigated so far stand the AMPA receptor (AMPAR) positive allosteric modulators (AMPARpams). For the last two decades, our laboratory has designed more than five hundred original 1,2,4-benzothiadiazine 1,1-dioxides and isosteres related to IDRA-21 acting as AMPARpams. Amongst these potentiators, stands BPAM344. Recent studies have led to the characterization of the crystallographic structure of the subunits composing kainic acid receptors (KArs) and more particularly their allosteric pocket. Thanks to the discovery of the binding mode of BPAM344 within this site, the design of selective positive allosteric for KArs seemed possible. Based on the preliminary results obtained with the first compounds, new series of benzothiadiazines dioxides have been imagined. The present work describes the obtention of a first key intermediate that should give access to a new set of potentiators, selective for GluK1-3 or GluK4-5 subunits KARs

Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency

10.1016/j.jhep.2015.10.008Journal of Hepatology642370-37