Review of experimental methods to determine spontaneous combustion susceptibility of coal – Indian context

This paper presents a critical review of the different techniques developed to investigate the susceptibility of coal to spontaneous combustion and fire. These methods may be sub-classified into the two following areas: (1) Basic coal characterisation studies (chemical constituents) and their influence on spontaneous combustion susceptibility. (2) Test methods to assess the susceptibility of a coal sample to spontaneous combustion. This is followed by a critical literature review that summarises previous research with special emphasis given to Indian coals

The Public Repository of Xenografts enables discovery and randomized phase II-like trials in mice

More than 90% of drugs with preclinical activity fail in human trials, largely due to insufficient efficacy. We hypothesized that adequately powered trials of patient-derived xenografts (PDX) in mice could efficiently define therapeutic activity across heterogeneous tumors. To address this hypothesis, we established a large, publicly available repository of well-characterized leukemia and lymphoma PDXs that undergo orthotopic engraftment, called the Public Repository of Xenografts (PRoXe). PRoXe includes all de-identified information relevant to the primary specimens and the PDXs derived from them. Using this repository, we demonstrate that large studies of acute leukemia PDXs that mimic human randomized clinical trials can characterize drug efficacy and generate transcriptional, functional, and proteomic biomarkers in both treatment-naive and relapsed/refractory disease

TRANSLATING THE PROBLEMS OF THE ELDERLY INTO EFFECTIVE POLICIES: AN ANALYSIS OF FILIAL ATTITUDES

This paper examines the political implications of current decision making efforts that underpin recent cost-cutting measures of federally supported programs serving the elderly. Current policy changes that favor the private sector (e.g., shifts of the cost of care to other levels of government and to elderly individuals and their families) have also generated a renewed interest in the policy of mandating family responsibility. The paper also examines attitudes concerning filial responsibility, such as multigenerational living. The inadequacy of current policy analysis that has encouraged the disestablishment of the current long-term care system and the shifting of care costs to the private sector, especially to the individual and the family are also examined. Copyright 1989 by The Policy Studies Organization.