Sensitivity analysis and experimental design of a stiff signal transduction pathway model

Sensitivity analysis is normally used to analyze how sensitive a system is with respect to the change of parameters or initial conditions and is perhaps best known in systems biology via the formalism of metabolic control analysis [1, 2]. The nuclear factor B (NF-B) signalling pathway is an important cellular signalling pathway, of which protein phosphorylation is a major factor controlling the activation of further downstream events. The NF-κB proteins regulate numerous genes that play important roles in inter- and intra-cellular signalling, cellular stress responses, cell growth, survival, and apoptosis. As such, its specificity and its role in the temporal control of gene expression are of crucial physiological interest

Towards hardware acceleration of neuroevolution for multimedia processing applications on mobile devices

This paper addresses the problem of accelerating large artificial neural networks (ANN), whose topology and weights can evolve via the use of a genetic algorithm. The proposed digital hardware architecture is capable of processing any evolved network topology, whilst at the same time providing a good trade off between throughput, area and power consumption. The latter is vital for a longer battery life on mobile devices. The architecture uses multiple parallel arithmetic units in each processing element (PE). Memory partitioning and data caching are used to minimise the effects of PE pipeline stalling. A first order minimax polynomial approximation scheme, tuned via a genetic algorithm, is used for the activation function generator. Efficient arithmetic circuitry, which leverages modified Booth recoding, column compressors and carry save adders, is adopted throughout the design

Antiflow of kaons in relativistic heavy ion collisions

We compare relativistic transport model calculations to recent data on the sideward flow of neutral strange K^0_s mesons for Au+Au collisions at 6 AGeV. A soft nuclear equation of state is found to describe very well the positive proton flow data measured in the same experiment. In the absence of kaon potential, the K^0 flow pattern is similar to that of protons. The kaon flow becomes negative if a repulsive kaon potential determined from the impulse approximation is introduced. However, this potential underestimates the data which exhibits larger antiflow. An excellent agreement with the data is obtained when a relativistic scalar-vector kaon potential, that has stronger density dependence, is used. We further find that the transverse momentum dependence of directed and elliptic flow is quite sensitive to the kaon potential in dense matter.Comment: 5 pages, Revtex, 4 figure

What does the rho-meson do? In-medium mass shift scenarios versus hadronic model calculations

The NA60 experiment has studied low-mass muon pair production in In-In collisions at $158 {\rm AGeV}$ with unprecedented precision. With these results there is hope that the in-medium modifications of the vector meson spectral function can be constrained more thoroughly than before. We investigate in particular what can be learned about collisional broadening by a hot and dense medium and what constrains the experimental results put on in-medium mass shift scenarios. The data show a clear indication of considerable in-medium broadening effects but disfavor mass shift scenarios where the $\rho$-meson mass scales with the square root of the chiral condensate. Scaling scenarios which predict at finite density a dropping of the $\rho$-meson mass that is stronger than that of the quark condensate are clearly ruled out since they are also accompanied by a sharpening of the spectral function.Comment: Proceeding contribution, Talk given by J. Ruppert at Workshop for Young Scientists on the Physics of Ultrarelativistic Nucleus-Nucleus Collisions (Hot Quarks 2006), Villasimius, Sardinia, Italy, 15-20 May 2006. To appear in EPJ

Surface Tension between Kaon Condensate and Normal Nuclear Matter Phase

We calculate for the first time the surface tension and curvature coefficient of a first order phase transition between two possible phases of cold nuclear matter, a normal nuclear matter phase in equilibrium with a kaon condensed phase, at densities a few times the saturation density. We find the surface tension is proportional to the difference in energy density between the two phases squared. Furthermore, we show the consequences for the geometrical structures of the mixed phase region in a neutron star.Comment: 7 pages, 5 figures (Latex

Choosing more mathematics : happiness through work?

This paper examines how A-level students construct relationships between work and happiness in their accounts of choosing mathematics and further mathematics A-level. I develop a theoretical framework that positions work and happiness as opposed, managed and working on the self and use this to examine students' dual engagement with individual practices of the self and institutional practices of school mathematics. Interviews with students acknowledge four imperatives that they use as discursive resources to position themselves as successful/unsuccessful students: you have to work, you have to not work, you have to be happy, you have to work at being happy. Tensions in these positions lead students to rework their identities or drop further mathematics. I then identify the practices of mathematics teaching that students use to explain un/happiness in work, and show how dependable mathematics and working together are constructed as 'happy objects' for students, who develop strategies for claiming control over these shapers of happiness. © 2010 British Society for Research into Learning Mathematics

The gravitationally lensed, luminous infrared galaxy IRAS F10214+4724 observed with XMM-Newton

We report on a short XMM-Newton observation of the gravitationally-lensed, luminous infrared galaxy IRAS F10214+4724 at z=2.3. A faint X-ray source is detected at 4 sigma. The observed 0.5-2 keV (1.7-6.6 keV in the rest-frame) flux is 1.3e-15 erg/s/cm2 and the spectral slope in the rest-frame 1-10 keV band is Gamma~2. These results agree with those obtained from the Chandra X-ray Observatory, given the large uncertainties in both measurements. While possible evidence for excess emission above 5 keV is seen, we suspect this excess might be either spurious or not related to the infrared galaxy.Comment: 4 pages, 2 figures, New Astronomy in pres

Closed Strings with Low Harmonics and Kinks

Low-harmonic formulas for closed relativistic strings are given. General parametrizations are presented for the addition of second- and third-harmonic waves to the fundamental wave. The method of determination of the parametrizations is based upon a product representation found for the finite Fourier series of string motion in which the constraints are automatically satisfied. The construction of strings with kinks is discussed, including examples. A procedure is laid out for the representation of kinks that arise from self-intersection, and subsequent intercommutation, for harmonically parametrized cosmic strings.Comment: 39, CWRUTH-93-