Time and dose dependency of bone-sarcomas in patients injected with radium-224

The time course and dose dependency of the incidence of bone-sarcomas among 900 German patients treated with high doses of radium-224 is analysed in terms of a proportional hazards model with a log-normal dependency of time to tumor and a linear-quadratic dose relation. The deduced dose dependency agrees well with a previous analysis in terms of a non-parametric proportional hazards model, and confirms the temporal distribution which has been used in the Radioepidemiological Tables of NIH. However, the linear-quadratic dose-response model gives a risk estimate for low doses which is somewhat less than half that obtained under the assumption of linearity. Dedicated to Prof. W. Jacobi on the occasion of his 60th birthday Work performed under Euratom contracts BI6-D-083-D, BI6-F-111-D, U.S. Department of Energy contract DE-AC 02-76 EV-00119, the U.S. National Cancer Institut

Towards Efficient Full Pose Omnidirectionality with Overactuated MAVs

Omnidirectional MAVs are a growing field, with demonstrated advantages for aerial interaction and uninhibited observation. While systems with complete pose omnidirectionality and high hover efficiency have been developed independently, a robust system that combines the two has not been demonstrated to date. This paper presents VoliroX: a novel omnidirectional vehicle that can exert a wrench in any orientation while maintaining efficient flight configurations. The system design is presented, and a 6 DOF geometric control that is robust to singularities. Flight experiments further demonstrate and verify its capabilities.Comment: 10 pages, 6 figures, ISER 2018 conference submissio

On Glauber modes in Soft-Collinear Effective Theory

Gluon interactions involving spectator partons in collisions at hadronic machines are investigated. We find a class of examples in which a mode, called Glauber gluons, must be introduced to the effective theory for consistency.Comment: 19 pages, three figures. Uses JHEP3.cl

Quotients of E^n by A_{n+1} and Calabi-Yau manifolds

We give a simple construction, starting with any elliptic curve E, of an n-dimensional Calabi-Yau variety of Kummer type (for any n>1), by considering the quotient Y of the n-fold self-product of E by a natural action of the alternating group A_{n+1} (in n+1 variables). The vanishing of H^m(Y, O_Y) for 0<m<n follows from the non-existence of (non-zero) fixed points in certain representations of A_{n+1}. For n<4 we provide an explicit crepant resolution X in characteristics different from 2,3. The key point is that Y can be realized as a double cover of P^n branched along a hypersurface of degree 2(n+1).Comment: 9 page

Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: Functional and therapeutic implications

This article is made available through the Brunel Open Access Publishing Fund. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.CLU (clusterin) is a tumor suppressor gene that we have previously shown to be negatively modulated by the MYCN proto-oncogene, but the mechanism of repression was unclear. Here, we show that MYCN inhibits the expression of CLU by direct interaction with the non-canonical E box sequence CACGCG in the 5′-flanking region. Binding of MYCN to the CLU gene induces bivalent epigenetic marks and recruitment of repressive proteins such as histone deacetylases and Polycomb members. MYCN physically binds in vitro and in vivo to EZH2, a component of the Polycomb repressive complex 2, required to repress CLU. Notably, EZH2 interacts with the Myc box domain 3, a segment of MYC known to be essential for its transforming effects. The expression of CLU can be restored in MYCN-amplified cells by epigenetic drugs with therapeutic results. Importantly, the anticancer effects of the drugs are ablated if CLU expression is blunted by RNA interference. Our study implies that MYC tumorigenesis can be effectively antagonized by epigenetic drugs that interfere with the recruitment of chromatin modifiers at repressive E boxes of tumor suppressor genes such as CLU.SPARKS, The Neuroblastoma Society, a Wellcome Trust grant (to A. S.), and the Italian Association for Cancer Research

Pure Samples of Quark and Gluon Jets at the LHC

Having pure samples of quark and gluon jets would greatly facilitate the study of jet properties and substructure, with many potential standard model and new physics applications. To this end, we consider multijet and jets+X samples, to determine the purity that can be achieved by simple kinematic cuts leaving reasonable production cross sections. We find, for example, that at the 7 TeV LHC, the pp {\to} {\gamma}+2jets sample can provide 98% pure quark jets with 200 GeV of transverse momentum and a cross section of 5 pb. To get 10 pb of 200 GeV jets with 90% gluon purity, the pp {\to} 3jets sample can be used. b+2jets is also useful for gluons, but only if the b-tagging is very efficient.Comment: 19 pages, 16 figures; v2 section on formally defining quark and gluon jets has been adde

Black holes and information theory

During the past three decades investigators have unveiled a number of deep connections between physical information and black holes whose consequences for ordinary systems go beyond what has been deduced purely from the axioms of information theory. After a self-contained introduction to black hole thermodynamics, we review from its vantage point topics such as the information conundrum that emerges from the ability of incipient black holes to radiate, the various entropy bounds for non-black hole systems (holographic bound, universal entropy bound, etc) which are most easily derived from black hole thermodynamics, Bousso's covariant entropy bound, the holographic principle of particle physics, and the subject of channel capacity of quantum communication channels.Comment: RevTeX, 12 pages, 5 figures. To appear in Contemporary Physic