ИСПОЛЬЗОВАНИЕ ГЕПАТОПРОТЕКТОРОВ У БОЛЬНЫХ РАКОМ ЯИЧНИКОВ

Objective: to evaluate the efficiency of pharmacological correction of endogenous intoxication in patients with Stages III—IV ovarian cancer (OC) in the perioperative period. Subjects and methods. Thirty-to-70-year old seventy patients with Stages III-IV OC who had been surgically treated under general anesthesia were examined. The bio chemical parameters of intoxication, such as middleweight molecules, the total, effective concentration and binding capacity of albumin, integral hematological indices of intoxication, and C-reactive protein, were studied in the perioperative period. Results. Analysis of the performed tests showed that the premorbid background in all the examinees was characterized by varying degrees of endogenous intoxication (EI), increased leukocytic index of intoxication, hematological index of intoxication, and modified hematological index of intoxication, an imbalance between the accumulation and binding of overproduced toxic ligands, the intensified production of acutephase inflammatory proteins by the activation of a systemic inflammatory response, and decreased systemic responsiveness. These changes occur with suppressed systemic responsiveness, inadequate intoxication compensation by physiological detoxification systems and hemostatic instability. Conclusion. The use of heptral and Remaxol as part of the metabolic pharmacological correction infusion program nonequivalently caused reductions in the activity of an inflammatory response and the efficiency of EI correction in patients with OC in the perioperative period. The administration of Remaxol for systemic hyporesponsiveness and pronounced intoxication in OC patients promoted the optimization of systemic responsiveness, by producing a reduced toxic effect of tumorassociated EI. Цель — оценить эффективность фармакологической коррекции эндогенной интоксикации у больных раком яичников III—IV стадии в периоперационном периоде. Материал и методы. Обследованы 70 больных раком яичников III—IV стадии, в возрасте от 30 до 70 лет, перенесших хирургический этап лечения в условиях общей анестезии. В периоперационном периоде изучены биохимические показатели интоксикации — молекулы средней массы, общая, эффективная концентрация и связывающая способность альбумина, гематологические интегральные индексы интоксикации, С-реактивный белок. Результаты. Анализ проведенных исследований показал, что у всех исследуемых больных преморбидный фон характеризовался разной степени выраженности эндогенной интоксикацией (ЭИ), ростом лейкоцитарного индекса интоксикации, гематологического показателя интоксикации, модифицированного гематологического показателя интоксикации, нарушением баланса накопления и связывания избыточно продуцируемых токсических лигандов, интенсификацией продукции белков острой фазы воспаления активизацией системного воспалительного ответа, снижением общей реактивности организма. Эти изменения происходят на фоне угнетения общей реактивности организма, неадекватной компенсации интоксикации физиологическими системами детоксикации и нестабильностью гомеостаза. Заключение. Использование в составе инфузионной программы метаболической фармакологической коррекции гептрала и Ремаксола неравнозначно способствовало уменьшению активности воспалительной реакции и эффективности коррекции ЭИ у больных РЯ в периоперационном периоде. Использование Ремаксола в условиях снижения общей реактивности организма и выраженной интоксикации у больных раком яичников способствует оптимизации общей реактивности организма, обеспечивая снижение токсического воздействия опухолевой ЭИ.

Functional disorders of the gastrointestinal tract in children of different age groups (a literature review)

In recent years, diseases of the gastrointestinal tract are becoming more common with economic and social impacts. It is believed that in terms of frequency, they rank second both among the adult and pediatric population, second only to respiratory system diseases. Due to significant morphological and physiological changes in individual organs and systems during the period of intensive development of a child, the formation of gastroenterological pathology occurs most often at the age of 5–6 or 9–12 years, that gives rise to various functional disorders of the gastrointestinal tract. There is an opinion that among older children, such functional disorders are often bordering on pathology, prompting pediatricians to an increased interest in their etiology, pathogenesis and current therapy. Aim. To highlight the state of the problem associated with the most frequent functional disorders of the gastrointestinal tract in children at the present stage. According to the recent recommendations, it has been recommended to consider functional changes as disorders of the interaction between the brain and the gastrointestinal tract (disorders of gut-brain interaction).The underlying disorders are abnormal motility, visceral hypersensitivity, the state of the gastrointestinal mucosa and local immune factors, intestinal microflora, activity of the central and autonomic nervous system. Most researchers tend to think about the key role of impaired autonomic regulation of sphincter activity in the pathogenesis of motor-evacuatory dysfunction of the alimentary canal in children, buoyed by the fact that often the lack of gastrointestinal organic lesions in motility disorders indicates their dysregulatory character. Conclusions. Functional disorders of the gastrointestinal tract have an extraordinary brightness of pain syndrome perception (no organic pathology would give such a wide array of symptoms as functional disorders) and a variable pattern of symptoms, so it becomes clear why these diseases impose a major economic burden, and it is this characteristic enables them to be classified as socially significant disorders. This requires a physician at various levels of medical care to provide timely diagnosis, differential diagnosis between organic gastrointestinal diseases, and timely correction of functional disorders

VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION LHS-1208 IN THE LYOPHILIZED DOSAGE FORM

In order to ensure reliable and accurate results, the authors carried out the validation procedure developed technique for spectrophotometric quantification of the active substance for the lyophilized liposomal formulation of national hydrophobic antitumor compounds from the group of indolocarbazole - LHS-1208. As a result of the establishment of the specificity, linearity, range of use, accuracy and precision of a validated method may be used in the range of 80-120% concentration LHS-1208 in the dosage form

PREPARATION AND ANALYSIS OF LYOPHILIZED DOSAGE FORM LHS-1208 BY THIN CHROMATOGRAPHY AND A SPECTROPHOTOMETERY

The work is dedicated to the development of technology for obtaining a freeze-dried dosage form LHS-1208 and the establishment of methods of quality control of the drug. The authors have shown spectrophotometric analysis techniques and flash chromatography