A Clinical Study on Vrana Shodhana Action of Gomutra Arka in Dushtavrana w.s.r. to Diabetic Foot Ulcer

Context: The diabetic foot ulcer, being chronic in nature involves various tissues, it can be considered as Dushtavrana in Ayurveda. Proper Care for diabetic foot with medication and procedures that has hastened the healing process with less complication is the need of the hour. Aim: To evaluate the Vrana Shodhana action of Gomutra Arka in Dushtavrana w.s.r. to diabetic foot ulcers. Settings and Design: It is a clinical study with pre-test and post-test design. Total number of patient’s taken for the study was 40 excluding dropouts. The patients selected for the study were divided in to 2 groups, Group-A and Group-B, consisting of 20 patients each. Materials and Methods: The wound is examined, exudates, debris, slough were removed, the surrounding area was cleaned and pad soaked in Gomutra Arka was placed and wound dressing was done once in a day. Duration of study was 45 days or till the formation of granulation tissue whichever is earlier, assessment was done every 7 days. For healing Jatyadi Taila was applied after the Shodhana Kriya with Gomutra Arka. Conclusion: Gomutra Arka was having good results in reducing burning sensation, itching, smell, size, depth, discharge, edge, floor and presence of granulation tissues compared to Betadine. Both drugs have equal effect in reducing pain. Both drugs have Shodhana, Lekhana properties, hastens the wound healing process which helps in reduction of wound size. It can be concluded that Gomutra Arka application is effective in all types of Diabetic foot ulcer by their faster, effective Shodhana, Lekhana, Vedana Shamaka, Kandu Shamaka, Daha Shamaka properties compared to Betadine

Effects of Molecular Crowding on stretching of polymers in poor solvent

We consider a linear polymer chain in a disordered environment modeled by percolation clusters on a square lattice. The disordered environment is meant to roughly represent molecular crowding as seen in cells. The model may be viewed as the simplest representation of biopolymers in a cell. We show the existence of intermediate states during stretching arising as a consequence of molecular crowding. In the constant distance ensemble the force-extension curves exhibit oscillations. We observe the emergence of two or more peaks in the probability distribution curves signaling the coexistence of different states and indicating that the transition is discontinuous unlike what is observed in the absence of molecular crowding.Comment: 14 pages, 6 figure

Normal mode analysis for scalar fields in BTZ black hole background

We analyze the possibility of inequivalent boundary conditions for a scalar field propagating in the BTZ black hole space-time. We find that for certain ranges of the black hole parameters, the Klein-Gordon operator admits a one-parameter family of self-adjoint extensions. For this range, the BTZ space-time is not quantum mechanically complete. We suggest a physically motivated method for determining the spectra of the Klein-Gordon operator.Comment: 6 pages, no figure, late

Sandpile Model with Activity Inhibition

A new sandpile model is studied in which bonds of the system are inhibited for activity after a certain number of transmission of grains. This condition impels an unstable sand column to distribute grains only to those neighbours which have toppled less than m times. In this non-Abelian model grains effectively move faster than the ordinary diffusion (super-diffusion). A novel system size dependent cross-over from Abelian sandpile behaviour to a new critical behaviour is observed for all values of the parameter m.Comment: 11 pages, RevTex, 5 Postscript figure

Effect of FCNC mediated Z boson on lepton flavor violating decays

We study the three body lepton flavor violating (LFV) decays $\mu^- \to e^- e^+ e^-$, $\tau^- \to l_i^- l_j^+ l_j^-$ and the semileptonic decay $\tau \to \mu \phi$ in the flavor changing neutral current (FCNC) mediated $Z$ boson model. We also calculate the branching ratios for LFV leptonic B decays, $B_{d,s} \to \mu e$, $B_{d,s} \to \tau e$, $B_{d,s} \to \tau \mu$ and the conversion of muon to electron in Ti nucleus. The new physics parameter space is constrained by using the experimental limits on $\mu^- \to e^- e^+ e^-$ and $\tau^- \to \mu^- \mu^+ \mu^-$. We find that the branching ratios for $\tau \to eee$ and $\tau \to \mu \phi$ processes could be as large as $\sim {\cal O}(10^{-8})$ and ${\rm Br}B_{d,s} \to \tau \mu, \tau e) \sim {\cal O}(10^{-10})$. For other LFV B decays the branching ratios are found to be too small to be observed in the near future.Comment: 15 pages, 8 figures, typos corrected, one more section added, version to appear in EPJ

On the reaction of keto acids with amino acids

This article does not have an abstract

SM with four generations: Selected implications for rare B and K decays

We extend our recent work and study implications of the Standard Model with four generations (SM4) for rare B and K decays. We again take seriously the several 2-3 $\sigma$ anomalies seen in B, $B_s$ decays and interpret them in the context of this simple extension of the SM. SM4 is also of course of considerable interest for its potential relevance to dynamical electroweak symmetry breaking and to baryogenesis. Using experimental information from processes such as $B \to X_s \gamma$, $B_d$ and $B_s$ mixings, indirect CP-violation from $K_L \to \pi \pi$ etc along with oblique corrections, we constrain the relevant parameter space of the SM4, and find $m_{t'}$ of about 400-600 GeV with a mixing angle $| V_{t'b}^*V_{t's}|$ in the range of about (0.05 to 1.4)$\times 10^{-2}$ and with an appreciable CP-odd associated phase, are favored by the current data. Given the unique role of the CP asymmetry in $B_s \to \psi \phi$ due to its gold-plated nature, correlation of that with many other interesting observables, including the semileptonic asymmetry ($A_{SL}$) are studied in SM4. We also identify several processes, such as $B \to X_s \nu \bar\nu$, $K_L \to \pi^0 \nu \bar \nu$ etc, that are significantly different in SM4 from the SM. Experimentally the very distinctive process $B_s\to \mu^+\mu^-$ is also discussed; the branching ratio can be larger or smaller than in SM, $(3.2 \to 4.2)\times 10^{-9}$, by a factor of ${\cal{O}}(3)$.Comment: v2: 49 pages, 20 eps figures, Corrected some typos, added few references and minor changes with regard to direct CP in K pi. Also some added information to facilitate direct comparison with Buras et al, arXiv:1002.2126