Suppression of dephasing by qubit motion in superconducting circuits

We suggest and demonstrate a protocol which suppresses dephasing due to the low-frequency noise by qubit motion, i.e., transfer of the logical qubit of information in a system of $n \geq 2$ physical qubits. The protocol requires only the nearest-neighbor coupling and is applicable to different qubit structures. We further analyze its effectiveness against noises with arbitrary correlations. Our analysis, together with experiments using up to three superconducting qubits, shows that for the realistic uncorrelated noises, qubit motion increases the dephasing time of the logical qubit as $\sqrt{n}$. In general, the protocol provides a diagnostic tool to measure the noise correlations.Comment: 5 pages with 3 embedded figures, plus supplementary informatio

Generation of GHZ entangled states of photons in multiple cavities via a superconducting qutrit or an atom through resonant interaction

We propose an efficient method to generate a GHZ entangled state of n photons in n microwave cavities (or resonators) via resonant interaction to a single superconducting qutrit. The deployment of a qutrit, instead of a qubit, as the coupler enables us to use resonant interactions exclusively for all qutrit-cavity and qutrit-pulse operations. This unique approach significantly shortens the time of operation which is advantageous to reducing the adverse effects of qutrit decoherence and cavity decay on fidelity of the protocol. Furthermore, the protocol involves no measurement on either the state of qutrit or cavity photons. We also show that the protocol can be generalized to other systems by replacing the superconducting qutrit coupler with different types of physical qutrit, such as an atom in the case of cavity QED, to accomplish the same task.Comment: 11 pages, 5 figures, accepted by Phys. Rev.

Quantum Phase Diffusion in a Small Underdamped Josephson Junction

Quantum phase diffusion in a small underdamped Nb/AlO$_x$/Nb junction ($\sim$ 0.4 $\mu$m$^2$) is demonstrated in a wide temperature range of 25-140 mK where macroscopic quantum tunneling (MQT) is the dominant escape mechanism. We propose a two-step transition model to describe the switching process in which the escape rate out of the potential well and the transition rate from phase diffusion to the running state are considered. The transition rate extracted from the experimental switching current distribution follows the predicted Arrhenius law in the thermal regime but is greatly enhanced when MQT becomes dominant.Comment: 4 pages, 4 figures, 1 tabl

Suppression of Dephasing by Qubit Motion in Superconducting Circuits

This work was supported by the National Basic Research Program of China (Grants No. 2014CB921200 and No. 2012CB927404), U.S. NSF Grants No. PHY-1314758 and No. PHY-1314861, the National Natural Science Foundation of China (Grants No. 11434008 and No. 11222437), and the Zhejiang Provincial Natural Science Foundation of China (Grant No. LR12A04001).We suggest and demonstrate a protocol which suppresses the low-frequency dephasing by qubit motion, i.e., transfer of the logical qubit of information in a system of n≥2 physical qubits. The protocol requires only the nearest-neighbor coupling and is applicable to different qubit structures. Our analysis of its effectiveness against noises with arbitrary correlations, together with experiments using up to three superconducting qubits, shows that for the realistic uncorrelated noises, qubit motion increases the dephasing time of the logical qubit as =√n. In general, the protocol provides a diagnostic tool for measurements of the noise correlations

Quantum and classical resonant escapes of a strongly-driven Josephson junction

The properties of phase escape in a dc SQUID at 25 mK, which is well below quantum-to-classical crossover temperature $T_{cr}$, in the presence of strong resonant ac driving have been investigated. The SQUID contains two Nb/Al-AlO$_{x}$/Nb tunnel junctions with Josephson inductance much larger than the loop inductance so it can be viewed as a single junction having adjustable critical current. We find that with increasing microwave power $W$ and at certain frequencies $\nu$ and $\nu$/2, the single primary peak in the switching current distribution, \textrm{which is the result of macroscopic quantum tunneling of the phase across the junction}, first shifts toward lower bias current $I$ and then a resonant peak develops. These results are explained by quantum resonant phase escape involving single and two photons with microwave-suppressed potential barrier. As $W$ further increases, the primary peak gradually disappears and the resonant peak grows into a single one while shifting further to lower $I$. At certain $W$, a second resonant peak appears, which can locate at very low $I$ depending on the value of $\nu$. Analysis based on the classical equation of motion shows that such resonant peak can arise from the resonant escape of the phase particle with extremely large oscillation amplitude resulting from bifurcation of the nonlinear system. Our experimental result and theoretical analysis demonstrate that at $T\ll T_{cr}$, escape of the phase particle could be dominated by classical process, such as dynamical bifurcation of nonlinear systems under strong ac driving.Comment: 10 pages, 9 figures, 1 tabl

MEK Guards Proteome Stability and Inhibits Tumor-Suppressive Amyloidogenesis via HSF1

SummarySignaling through RAS/MAP kinase pathway is central to biology. ERK has long been perceived as the only substrate for MEK. Here, we report that HSF1, the master regulator of the proteotoxic stress response, is a new MEK substrate. Beyond mediating cell-environment interactions, the MEK-HSF1 regulation impacts malignancy. In tumor cells, MEK blockade inactivates HSF1 and thereby provokes proteomic chaos, presented as protein destabilization, aggregation, and, strikingly, amyloidogenesis. Unlike their non-transformed counterparts, tumor cells are particularly susceptible to proteomic perturbation and amyloid induction. Amyloidogenesis is tumor suppressive, reducing in vivo melanoma growth and contributing to the potent anti-neoplastic effects of proteotoxic stressors. Our findings unveil a key biological function of the oncogenic RAS-MEK signaling in guarding proteostasis and suppressing amyloidogenesis. Thus, proteomic instability is an intrinsic feature of malignant state, and disrupting the fragile tumor proteostasis to promote amyloidogenesis may be a feasible therapeutic strategy