5 research outputs found
Effects of diet on blood rheological indices, cytokine concentrations, and emergence of metabolic disorders in the persons with increased body mass index
Metabolic syndrome (MS) is a serious medical and social problem due to its high prevalence, lack of common approaches to diagnosis and treatment. Prevention of food dysadaptation reactions and the studies of control mechanisms of immune tolerance to food antigens is of special scientific interest, thus providing available anti-inflammatory tools for correcting increased permeability of the intestinal epithelium and vascular endothelium associated with development of MS. Nutritional dysadaptation occurs due to inappropriate diet being mediated by the geno-phenotypic characteristics of digestive enzymes and immune system which control the efficiency of food digestion.Immunological control of digestion, including dynamic maintenance of tolerance to food antigens, is carried out at two levels of immune system: innate response with functional involvement of microbiota, and adaptive response, represented by cellular and humoral mechanisms associated with molecular epitopes and critical mass of persistent food antigens which are present in immunologically competent areas of small intestine, due to changing permeability of intestinal barrier and transcytosis processes. Patients and methods: aiming for assessment of the diet contribution to the immuno-biochemical and rheological imbalance in people with increased body weight, 170 volunteers of both sexes aged 20-55 years were examined, depending on the body mass index: > 27.0 kg/m2 (clinical group, n = 120), and those with BMI of < 25.0 kg/m2 (control group, n = 50). We have revealed statistically significant increase of multiple parameters in the clinical group, i.e., concentration of IL-6, IL-17, cholesterol, glucose, glycosylated hemoglobin, insulin, indices of insulin resistance and atherogenicity. Increased levels of specific IgG antibodies to a number of food antigens were found in the subjects in the clinical group. In the course of our study, a statistically significant relationships was found between total numbers of platelets (p < 0.05; r = 0.213), erythrocytes (p < 0.05; r = -0.211), mean erythrocyte volume (MCV) (p < 0, 05; r = 0.339), and the concentration of IgG to casein in the blood, as well as a correlation between the levels of sIgG to soybeans and the number of platelets (p < 0.05; r = 0.231). At the same time, some associations were found between the established values of IgG to casein pAG, and the risk of developing atherogenic changes (atherogenicity index > 3) being significant at OR = 2.68 (1.33-5.42), as well as between IgG values to casein pAG (OR = 8.9 (2.6-30.5)), to soybean pAG (OR = 5.6 (1.8-16.7)), to gluten pAG ((F = 0.00359. p < 0.05), and increased body mass index.The results obtained were interpreted as a possible impairment of food tolerance for a number of food antigens in individuals with high body mass index, due to the revealed correlations between concentrations of IgG to food antigens, imbalance of pro-inflammatory cytokines, rheological and metabolic parameters. These data may be used as biomarkers suggesting higher risk of evolving metabolic syndrome
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ Π΄Π΅Π½Π΄ΡΠΈΡΠ½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΈ ΡΠΈΡΠΎΠΊΠΈΠ½ΠΎΠ² Π² ΠΊΠΎΠΆΠ΅ ΠΏΡΠΈ Π°ΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠΌ Π΄Π΅ΡΠΌΠ°ΡΠΈΡΠ΅
To study CD1a+ Langerhans cells and their extensions in epidermis and values of IL-4, IL-10, IL-17 and IFN-g in cell-free skin exudate there have been examined 40 patients of atopic dermatitis depending on phase pathological process. There have been found an increase in both CD1a+ dendritic extensions in medium layer of the epidermis and IL-4 and IL-10 in skin exudates. IFN-g exudateβs value has been decreased.ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ ΠΊΠΎΠΆΠ½ΡΠ΅ Π±ΠΈΠΎΠΏΡΠ°ΡΡ ΠΈ Π±Π΅ΡΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠ΅ ΡΡΠ°ΠΊΡΠΈΠΈ ΡΠΊΡΡΡΠ΄Π°ΡΠ° ΠΊΠΎΠΆΠ½ΠΎΠ³ΠΎ ΠΎΠΊΠ½Π° Ρ 40 Π±ΠΎΠ»ΡΠ½ΡΡ
Π°ΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΈΠΌ Π΄Π΅ΡΠΌΠ°ΡΠΈΡΠΎΠΌ. ΠΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈΡΡ CD1a + -ΠΊΠ»Π΅ΡΠΊΠΈ ΠΠ°Π½Π³Π΅ΡΠ³Π°Π½ΡΠ° ΠΈ ΠΈΡ
ΠΎΡΡΠΎΡΡΠΊΠΈ ΠΈ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΠΈΠ½ΡΠ΅ΡΠ»Π΅ΠΉΠΊΠΈΠ½ΠΎΠ²-4, -10, -17 ΠΈ ΠΈΠ½ΡΠ΅ΡΡΠ΅ΡΠΎΠ½Π°-Ξ³ Π² Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ΅ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ°. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΡΠΈΡΠ»Π° Π΄Π΅Π½Π΄ΡΠΈΡΠ½ΡΡ
ΠΎΡΡΠΎΡΡΠΊΠΎΠ² ΠΊΠ»Π΅ΡΠΎΠΊ ΠΠ°Π½Π³Π΅ΡΠ³Π°Π½ΡΠ° Π² ΡΡΠ΅Π΄Π½Π΅ΠΉ ΡΡΠ΅ΡΠΈ ΡΠΏΠΈΠ΄Π΅ΡΠΌΠΈΡΠ°, ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΉ ΠΈΠ½ΡΠ΅ΡΠ»Π΅ΠΉΠΊΠΈΠ½ΠΎΠ²-4 ΠΈ -10 ΠΈ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ ΠΈΠ½ΡΠ΅ΡΡΠ΅ΡΠΎΠ½Π°-Ξ³ Π² ΠΊΠΎΠΆΠ½ΡΡ
ΡΠΊΡΡΡΠ΄Π°ΡΠ°Ρ
Π¦ΠΈΡΠΎΠΊΠΈΠ½Ρ Β«ΠΊΠΎΠΆΠ½ΠΎΠ³ΠΎ ΠΎΠΊΠ½Π°Β» ΠΏΡΠΈ Π°ΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠΌ Π΄Π΅ΡΠΌΠ°ΡΠΈΡΠ΅
There have been defined IL-4, IL-10, IL-17 and IFN-Ξ³ in cell-free skin exudate in 90 patients of atopic dermatitis depending on spread of dermal pathological process. There been found that variations of each cytokine had different features and reflected different parts of immunopathogenesis of the disease both in an acute period and remission and after allergenspecific immunotherapy.Π Π±Π΅ΡΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΡΡΠ°ΠΊΡΠΈΠΈ ΡΠΊΡΡΡΠ΄Π°ΡΠ° Β«ΠΊΠΎΠΆΠ½ΠΎΠ³ΠΎ ΠΎΠΊΠ½Π°Β» Ρ 90 Π±ΠΎΠ»ΡΠ½ΡΡ
Π°ΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΈΠΌ Π΄Π΅ΡΠΌΠ°ΡΠΈΡΠΎΠΌ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡ ΠΈΠ½ΡΠ΅ΡΠ»Π΅ΠΉΠΊΠΈΠ½ΠΎΠ²-4, -10, -17 ΠΈ ΠΈΠ½ΡΠ΅ΡΡΠ΅ΡΠΎΠ½Π°-Ξ³ Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΡΡΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ° Π½Π° ΠΊΠΎΠΆΠ΅. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΊΠΎΠ»Π΅Π±Π°Π½ΠΈΡ ΠΊΠ°ΠΆΠ΄ΠΎΠ³ΠΎ ΠΈΠ· ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π½ΡΡ
ΡΠΈΡΠΎΠΊΠΈΠ½ΠΎΠ² Π½ΠΎΡΠΈΠ»ΠΈ ΡΠ°Π·Π½ΠΎΠ½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΡΠΉ Ρ
Π°ΡΠ°ΠΊΡΠ΅Ρ ΠΈ ΠΎΡΡΠ°ΠΆΠ°Π»ΠΈ ΡΠ°Π·Π½ΡΠ΅ ΡΡΠΎΡΠΎΠ½Ρ ΠΈΠΌΠΌΡΠ½ΠΎΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π° Π±ΠΎΠ»Π΅Π·Π½ΠΈ Π² ΠΏΠ΅ΡΠΈΠΎΠ΄ ΠΎΠ±ΠΎΡΡΡΠ΅Π½ΠΈΡ, ΡΠ΅ΠΌΠΈΡΡΠΈΠΈ ΠΈ ΠΏΠΎΡΠ»Π΅ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ
Dendritic cells and cytokines in skin in atopic dermatitis
To study CD1a+ Langerhans cells and their extensions in epidermis and values of IL-4, IL-10, IL-17 and IFN-g in cell-free skin exudate there have been examined 40 patients of atopic dermatitis depending on phase pathological process. There have been found an increase in both CD1a+ dendritic extensions in medium layer of the epidermis and IL-4 and IL-10 in skin exudates. IFN-g exudateβs value has been decreased
Β«Skin windowΒ» cytokines in atopic dermatitis
There have been defined IL-4, IL-10, IL-17 and IFN-Ξ³ in cell-free skin exudate in 90 patients of atopic dermatitis depending on spread of dermal pathological process. There been found that variations of each cytokine had different features and reflected different parts of immunopathogenesis of the disease both in an acute period and remission and after allergenspecific immunotherapy