BCL-6 and other genomic alterations in non-Hodgkin's lymphoma (NHL).

This study reports on the frequency and disease association pattern of a number of gene rearrangements in a large panel of lymphoid tumours (n = 94). We detected the t(11;14) translocation, involving rearrangement of the BCL-1 locus, in 60% of mantle cell lymphomas. The BCL-2 gene, located at band 18q21, was rearranged in 42% of follicle centre lymphomas (FCL) and in 15% of diffuse large B-cell (DLBC) lymphomas. In this study, 80% of the c-MYC rearrangements were detected in aggressive diffuse lymphoma subsets but, interestingly, 9% of FCL showed involvement of t(8q24) translocation. In our study, rearrangements of the BCL-6 gene at band 3q27 were found in 31% of DLBC lymphomas. Interestingly, 50% of the BCL-6 rearrangement positive lymphoma cases had coexisting gene rearrangements involving all of the aforementioned gene loci. The molecular dissection of these genes will improve our understanding of the genesis of the diverse clinicopathological subtypes

Increased H2_2CO production in the outer disk around HD 163296

Three formaldehyde lines were observed (H$_2$CO 3$_{03}$--2$_{02}$, H$_2$CO 3$_{22}$--2$_{21}$, and H$_2$CO 3$_{21}$--2$_{20}$) in the protoplanetary disk around the Herbig Ae star HD 163296 with ALMA at 0.5 arcsecond (60 AU) spatial resolution. H$_2$CO 3$_{03}$--2$_{02}$ was readily detected via imaging, while the weaker H$_2$CO 3$_{22}$--2$_{21}$ and H$_2$CO 3$_{21}$--2$_{20}$ lines required matched filter analysis to detect. H$_2$CO is present throughout most of the gaseous disk, extending out to 550 AU. An apparent 50 AU inner radius of the H$_2$CO emission is likely caused by an optically thick dust continuum. The H$_2$CO radial intensity profile shows a peak at 100 AU and a secondary bump at around 300 AU, suggesting increased production in the outer disk. Different parameterizations of the H$_2$CO abundance were compared to the observed visibilities with $\chi^2$ minimization, using either a characteristic temperature, a characteristic radius or a radial power law index to describe the H$_2$CO chemistry. Similar models were applied to ALMA Science Verification data of C$^{18}$O. In all modeling scenarios, fits to the H$_2$CO data show an increased abundance in the outer disk. The overall best-fit H$_2$CO model shows a factor of two enhancement beyond a radius of 270$\pm$20 AU, with an inner abundance of $2\!-\!5 \times 10^{-12}$. The H$_2$CO emitting region has a lower limit on the kinetic temperature of $T > 20$ K. The C$^{18}$O modeling suggests an order of magnitude depletion in the outer disk and an abundance of $4\!-\!12 \times 10^{-8}$ in the inner disk. The increase in H$_2$CO outer disk emission could be a result of hydrogenation of CO ices on dust grains that are then sublimated via thermal desorption or UV photodesorption, or more efficient gas-phase production beyond about 300 AU if CO is photodisocciated in this region

A germline TaqI restriction fragment length polymorphism in the progesterone receptor gene in ovarian carcinoma.

Clinical outcome in ovarian carcinoma is predicted by progesterone receptor status, indicating an endocrine aspect to this disease. Peripheral leucocyte genomic DNAs were obtained from 41 patients with primary ovarian carcinoma and 83 controls from Ireland, as well as from 26 primary ovarian carcinoma patients and 101 controls in Germany. Southern analysis using a human progesterone receptor (hPR) cDNA probe identified a germline TaqI restriction fragment length polymorphism (RFLP) defined by two alleles: T1, represented by a 2.7 kb fragment; and T2, represented by a 1.9 kb fragment and characterised by an additional TaqI restriction site with respect to T1. An over-representation of T2 in ovarian cancer patients compared with controls in the pooled Irish/German population (P < 0.025) was observed. A difference (P < 0.02) in the distribution of the RFLP genotypes between Irish and German control populations was also observed. The allele distributions could not be shown to differ significantly from Hardy-Weinberg distribution in any subgroup. Using hPR cDNA region-specific probes, the extra TaqI restriction site was mapped to intron G of the hPR gene

Rubidium and lead abundances in giant stars of the globular clusters M4 and M5

We present measurements of the neutron-capture elements Rb and Pb for bright giants in the globular clusters M4 and M5. The clusters are of similar metallicity ([Fe/H] = -1.2) but M4 is decidedly s-process enriched relative to M5: [Ba/Fe] = +0.6 for M4 but 0.0 for M5. The Rb and Pb abundances were derived by comparing synthetic spectra with high-resolution, high signal-to-noise ratio spectra obtained with MIKE on the Magellan telescope. Abundances of Y, Zr, La, and Eu were also obtained. In M4, the mean abundances from 12 giants are [Rb/Fe] = 0.39 +/- 0.02 (sigma = 0.07), [Rb/Zr] = 0.17 +/- 0.03 (sigma = 0.08), and [Pb/Fe] = 0.30 +/- 0.02 (sigma = 0.07). In M5, the mean abundances from two giants are [Rb/Fe] = 0.00 +/- 0.05 (sigma = 0.06), [Rb/Zr] = 0.08 +/- 0.08 (sigma = 0.11), and [Pb/Fe] = -0.35 +/- 0.02 (sigma = 0.04). Within the measurement uncertainties, the abundance ratios [Rb/Fe], [Pb/Fe] and [Rb/X] for X = Y, Zr, La are constant from star-to-star in each cluster and none of these ratios are correlated with O or Na abundances. While M4 has a higher Rb abundance than M5, the ratios [Rb/X] are similar in both clusters indicating that the nature of the s-products are very similar for each cluster but the gas from which M4's stars formed had a higher concentration of these products.Comment: Accepted for publication in Ap

A halo blue straggler on a highly eccentric retrograde orbit

Blue straggler, which are stars that appear to be younger than they should be, are an important population of unusual stars in both stellar clusters and the halo field of the Galaxy. Most formation scenarios evoke either stellar collisions or binary stars that transfer mass or merge. We investigate high-velocity stars in the Galactic halo and perform a spectral and kinematical analysis to shed light on their nature and origin. Here we report that SDSSJ130005.62+042201.6 (J1300+0422 for short) is an A-type star of unusually large radial velocity (504.6 $\pm$ 5 \kms). From a quantitative NLTE (and LTE) spectral analysis of medium-resolution optical spectra, the elemental composition is derived. Proper motion measurements combined with a spectroscopic distance estimate allow us to determine its present space velocity. Its kinematical properties are derived by integrating the equation of motion in the Galactic potential. We find J1300+0422 to be metal poor ([M/H]=$-1.2$) and exhibit an $\alpha$-element enrichment ($0.3-0.4$~dex) that is characteristic of the halo population, as confirmed by a kinematical analysis of its 3D space motions, which places it on a highly eccentric retrograde Galactic orbit. The mass of J1300+0422 (1.15 $\pm$ 0.10 M$_\odot$) is higher than the globular cluster turn-off masses indicating that it is a halo blue straggler star. At a Galactic rest-frame velocity of $\approx$467~\kms, the star travels faster than any known blue straggler but is still bound to the Galaxy.Comment: 6 pages, 7 figures, accepted for publication in A&

Computational lens for the near field

A method is presented to reconstruct the structure of a scattering object from data acquired with a photon scanning tunneling microscope. The data may be understood to form a Gabor type near-field hologram and are obtained at a distance from the sample where the field is defocused and normally uninterpretable. Object structure is obtained by the solution of the inverse scattering problem within the accuracy of a perturbative, two-dimensional model of the object

Evaluating Barriers to Health in Homebound Individuals

Introduction. Homebound individuals in Vermont often have multiple comorbidities and can face significant food insecurity. In response to this problem, the Chittenden County Emergency Food Shelf (CEFS) Homebound Delivery Program (HDP) delivers one week of food per month to 130 individuals in Chittenden County, Vermont.https://scholarworks.uvm.edu/comphp_gallery/1084/thumbnail.jp

Inflation with General Initial Conditions for Scalar Perturbations

We explore the possibility of a single field quasi-de Sitter inflationary model with general initial state for primordial fluctuations. In this paper, first we compute the power spectrum and the bispectrum of scalar perturbations with coherent state as the initial state. We find that a large class of coherent states are indistinguishable from the Bunch-Davies vacuum state and hence consistent with the current observations. In case of a more general initial state built over Bunch-Davies vacuum state, we show that the constraints on the initial state from observed power spectrum and local bispectrum are relatively weak and for quasi-de Sitter inflation a large number of initial states are consistent with the current observations. However, renormalizability of the energy-momentum tensor of the fluctuations constraints the initial state further.Comment: Updated to match published version, 20 page