Repair of a Fractured Femur and Fractured Femoral Neck Using the ASIF* Technique: A Case Report

On August 26, 1968, a one and one-half-year old, 65 pound (30kg), male German Shepherd was referred to the Stange Memorial clinic with a history of being struck by an auto one day prior. The referring veterinarian had examined the patient and found that a femoral fracture was present

Practice and Institutional Exchanges within the Residency Training Program

All residency programs have a common end goal; that of a competently trained specialist. The general public is demanding a much more sophisticated level of veterinary practice than ever before. As the need for more highly skilled general practitioners has increased. so has the need for specialty trained practitioners

Ventral Decompression of the Cervical Spinal Cord in the Dog

Cervical intervertebral disc herniation (CIDH) occurs most commonly in the chrondrodystrophic breeds of dogs. It is usually associated with degeneration of the disc and calcification of the nucleus pulposus which allows this disc material to herniate. Clinical signs such as pain, ataxia, careful placement of feet when walking, and sometimes paralysis are seen. In cases of partial or complete paralysis three surgical treatments are available: ventral fenestration, dorsal laminectomy, ventral decompression. Ventral decompression provides good surgical exposure and relieves pressure on the cervical spinal cord

Hepatic insulin resistance and altered gluconeogenic pathway in premature baboons

Premature infants have altered glucose regulation early in life and increased risk for diabetes in adulthood. Although prematurity leads to an increased risk of diabetes and metabolic syndrome in adult life, the role of hepatic glucose regulation and adaptation to an early extrauterine environment in preterm infants remain unknown. The purpose of this study was to investigate developmental differences in glucose metabolism, hepatic protein content, and gene expression of key insulin-signaling/gluconeogenic molecules. Fetal baboons were delivered at 67%, 75%, and term gestational age and euthanized at birth. Neonatal baboons were delivered prematurely (67% gestation), survived for two weeks, and compared with similar postnatal term animals and underwent serial hyperinsulinemic-euglycemic clamp studies. Premature baboons had decreased endogenous glucose production (EGP) compared with term animals. Consistent with these results, the gluconeogenic molecule, phosphoenolpyruvate carboxykinase messenger RNA, was decreased in preterm baboons compared with terms. Hepatic insulin signaling was altered by preterm birth as evidenced by decreased insulin receptor-b, p85 subunit of phosphoinositide 3-kinase, phosphorylated insulin receptor substrate 1, and Akt-1 under insulin-stimulated conditions. Furthermore, preterm baboons failed to have the normal increase in glycogen synthase kinase-a from fetal to postnatal life. The blunted responses in hepatic insulin signaling may contribute to the hyperglycemia of prematurity, while impaired EGP leads to hypoglycemia of prematurity

Inhaled nitric oxide in premature infants: effect on tracheal aspirate and plasma nitric oxide metabolites

ObjectiveInhaled nitric oxide (iNO) is a potential new therapy for prevention of bronchopulmonary dysplasia and brain injury in premature infants. This study examined dose-related effects of iNO on NO metabolites as evidence of NO delivery.Study designA subset of 102 premature infants in the NO CLD trial, receiving 24 days of iNO (20 p.p.m. decreasing to 2 p.p.m.) or placebo, were analyzed. Tracheal aspirate (TA) and plasma samples collected at enrollment and at intervals during study gas were analyzed for NO metabolites.ResultiNO treatment increased NO metabolites in TA at 20 and 10 p.p.m. (1.7- to 2.3-fold vs control) and in plasma at 20, 10, and 5 p.p.m. (1.6- to 2.3-fold). In post hoc analysis, treated infants with lower metabolite levels at entry had an improved clinical outcome.ConclusioniNO causes dose-related increases in NO metabolites in the circulation as well as lung fluid, as evidenced by TA analysis, showing NO delivery to these compartments

Practice and Institutional Exchanges within the Residency Training Program

All residency programs have a common end goal; that of a competently trained specialist. The general public is demanding a much more sophisticated level of veterinary practice than ever before. As the need for more highly skilled general practitioners has increased. so has the need for specialty trained practitioners.</p

Repair of a Fractured Femur and Fractured Femoral Neck Using the ASIF* Technique: A Case Report

On August 26, 1968, a one and one-half-year old, 65 pound (30kg), male German Shepherd was referred to the Stange Memorial clinic with a history of being struck by an auto one day prior. The referring veterinarian had examined the patient and found that a femoral fracture was present.</p

Ventral Decompression of the Cervical Spinal Cord in the Dog

Cervical intervertebral disc herniation (CIDH) occurs most commonly in the chrondrodystrophic breeds of dogs. It is usually associated with degeneration of the disc and calcification of the nucleus pulposus which allows this disc material to herniate. Clinical signs such as pain, ataxia, careful placement of feet when walking, and sometimes paralysis are seen. In cases of partial or complete paralysis three surgical treatments are available: ventral fenestration, dorsal laminectomy, ventral decompression. Ventral decompression provides good surgical exposure and relieves pressure on the cervical spinal cord.</p

Understanding Increased Ferritin Levels in Pediatric ECMO Patients

Abnormally high serum ferritin levels have been reported during pediatric ECMO, attributed to frequent red blood cell transfusion and suggestive of iron overload. However, the utility of ferritin for diagnosing iron overload is complicated by its response as an acute-phase reactant. In this study, we aimed to assess the utility of ferritin for diagnosing ECMO-related iron overload, with secondary aims of understanding its relationship with inflammation and erythropoiesis. Ferritin was elevated in all pediatric ECMO runs (median 459 ng/ml, IQR = 327.3-694.4). While intermittent elevations in serum iron were observed, all normalized prior to decannulation. Unreported previously, erythropoietin (EPO) remained well above normative values prior to and throughout ECMO runs, despite frequent transfusion and exposure to hyperoxia. Ferritin correlated poorly with serum iron [r(80) = 0.05, p = 0.65], but correlated well with IL-6 [r(76) = 0.48, p \u3c 0.001] and EPO [r(81) = 0.55, p \u3c 0.001]. We suggest that serum ferritin is a poor biomarker of iron overload in ECMO patients, and that future investigation into its relationship with EPO is warranted