Early child care and adiposity at kindergarten entry

The association between pre-school child care participation and markers of adiposity at kindergarten entry was examined using parent reported previous child care exposure and directly measured body mass index (BMI) and waist circumference (WC) of kindergarten children (N=201; boys=106, girls=95). It was hypothesized that kindergarten children with previous exposure to full-time non-parent child care (FNPC; \u3e20h/week) would have increased risk of overweight/obesity (BMI≥ 85th percentile) and high central adiposity (WC ≥80th percentile) compared to parent care (PC). The data suggest that there was no significant relationship between FNPC (n=112) and risk of overweight/obesity (OR=1.17, 95% CI=0.58-2.34, p=0.66) or central adiposity (OR=1.82, 95% CI=0.95-3.50, p=0.71). However, girls in the FNPC group had greater BMI (PC=15.3±1.6 kg/m2vs FNPC=16.1± 1.5 kg/m2; p=0.03) and WC (PC=51.7±4.1 cm vs FNPC=53.8±4.1 cm; p=0.02) values compared to PC. These differences were not found in boys. These findings suggest that girls exposed to non-parent care during early years may be vulnerable to increased adiposity

Contamination of histology biopsy specimen - a potential source of error for surgeons: a case report

Tissue contamination is a common occurrence in pathology, but surgeons are relatively unaware of this. We present the case of a 45-year-old man with Barrett's oesophagus, in which the histology of routine biopsies of an asymptomatic patient, were reported as 'carcinoma in situ'. Further biopsies were taken over a three month period but showed no evidence of malignancy. Tissue contamination or 'cross over' was identified as the likely cause of the abnormal result. This case report highlights the importance of the correlation of the clinical and histopathological findings and tissue contamination should be considered when both of these findings are not consistent

Rubidium in Metal-Deficient Disk and Halo Stars

We report the first extensive study of stellar Rb abundances. High-resolution spectra have been used to determine, or set upper limits on, the abundances of this heavy element and the associated elements Y, Zr, and Ba in 44 dwarfs and giants with metallicities spanning the range -2.0 <[Fe/H] < 0.0. In metal-deficient stars Rb is systematically overabundant relative to Fe; we find an average [Rb/Fe] of +0.21 for the 32 stars with [Fe/H] < -0.5 and measured Rb. This behavior contrasts with that of Y, Zr, and Ba, which, with the exception of three new CH stars (HD 23439A and B and BD +5 3640), are consistently slightly deficient relative to Fe in the same stars; excluding the three CH stars, we find the stars with [Fe/H] < -0.5 have average [Y/Fe], [Zr/Fe], and [Ba/Fe] of --0.19 (24 stars), --0.12 (28 stars), and --0.06 (29 stars), respectively. The different behavior of Rb on the one hand and Y, Zr, and Ba on the other can be attributed in part to the fact that in the Sun and in these stars Rb has a large r-process component while Y, Zr, and Ba are mostly s-process elements with only small r-process components. In addition, the Rb s-process abundance is dependent on the neutron density at the s-processing site. Published observations of Rb in s-process enriched red giants indicate a higher neutron density in the metal-poor giants. These observations imply a higher s-process abundance for Rb in metal-poor stars. The calculated combination of the Rb r-process abundance, as estimated for the stellar Eu abundances, and the s-process abundance as estimated for red giants accounts satisfactorily for the observed run of [Rb/Fe] with [Fe/H].Comment: 23 pages, 5 tables, 7 figure

The Discovery of Stellar Oscillations in the Planet Hosting Giant Star Beta Geminorum

We present the results of a long time series of precise stellar radial velocity measurements of the planet hosting K giant star Beta Geminorum. A total of 20 hours of observations spanning three nights were obtained and the radial velocity variations show the presence of solar-like stellar oscillations. Our period analysis yields six significant pulsation modes that have frequencies in the range of 30 - 150 microHz. The dominant mode is at a frequency of 86.9 microHz and has an amplitude of 5.3 m/s. These values are consistent with stellar oscillations for a giant star with a stellar mass of approximately 2 solar masses. This stellar mass implies a companion minimum mass of 2.6 Jupiter masses. Beta Gem is the first planet hosting giant star in which multi-periodic stellar oscillations have been detected. The study of stellar oscillations in planet hosting giant stars may provide an independent, and more accurate determination of the stellar mass.Comment: 12 pages preprint, 2 figures, accepted by ApJ Letter

A patient-specific multi-modality abdominal aortic aneurysm imaging phantom

PURPOSE: Multimodality imaging of the vascular system is a rapidly growing area of innovation and research, which is increasing with awareness of the dangers of ionizing radiation. Phantom models that are applicable across multiple imaging modalities facilitate testing and comparisons in pre-clinical studies of new devices. Additionally, phantom models are of benefit to surgical trainees for gaining experience with new techniques. We propose a temperature-stable, high-fidelity method for creating complex abdominal aortic aneurysm phantoms that are compatible with both radiation-based, and ultrasound-based imaging modalities, using low cost materials. METHODS: Volumetric CT data of an abdominal aortic aneurysm were acquired. Regions of interest were segmented to form a model compatible with 3D printing. The novel phantom fabrication method comprised a hybrid approach of using 3D printing of water-soluble materials to create wall-less, patient-derived vascular structures embedded within tailored tissue-mimicking materials to create realistic surrounding tissues. A non-soluble 3-D printed spine was included to provide a radiological landmark. RESULTS: The phantom was found to provide realistic appearances with intravascular ultrasound, computed tomography and transcutaneous ultrasound. Furthermore, the utility of this phantom as a training model was demonstrated during a simulated endovascular aneurysm repair procedure with image fusion. CONCLUSION: With the hybrid fabrication method demonstrated here, complex multimodality imaging patient-derived vascular phantoms can be successfully fabricated. These have potential roles in the benchtop development of emerging imaging technologies, refinement of novel minimally invasive surgical techniques and as clinical training tools

Integrated multi-modality image-guided navigation for neurosurgery: open-source software platform using state-of-the-art clinical hardware.

PURPOSE: Image-guided surgery (IGS) is an integral part of modern neuro-oncology surgery. Navigated ultrasound provides the surgeon with reconstructed views of ultrasound data, but no commercial system presently permits its integration with other essential non-imaging-based intraoperative monitoring modalities such as intraoperative neuromonitoring. Such a system would be particularly useful in skull base neurosurgery. METHODS: We established functional and technical requirements of an integrated multi-modality IGS system tailored for skull base surgery with the ability to incorporate: (1) preoperative MRI data and associated 3D volume reconstructions, (2) real-time intraoperative neurophysiological data and (3) live reconstructed 3D ultrasound. We created an open-source software platform to integrate with readily available commercial hardware. We tested the accuracy of the system's ultrasound navigation and reconstruction using a polyvinyl alcohol phantom model and simulated the use of the complete navigation system in a clinical operating room using a patient-specific phantom model. RESULTS: Experimental validation of the system's navigated ultrasound component demonstrated accuracy of [Formula: see text] and a frame rate of 25 frames per second. Clinical simulation confirmed that system assembly was straightforward, could be achieved in a clinically acceptable time of [Formula: see text] and performed with a clinically acceptable level of accuracy. CONCLUSION: We present an integrated open-source research platform for multi-modality IGS. The present prototype system was tailored for neurosurgery and met all minimum design requirements focused on skull base surgery. Future work aims to optimise the system further by addressing the remaining target requirements