3,853 research outputs found
Online prevention of disordered eating in at-risk young-adult women: A two-country pragmatic randomized controlled trial
This article has been published in a revised form in Psychological Medicine. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © Cambridge University Press 2017.
This author accepted manuscript is made available following 6 month embargo from date of publication (Dec 2017) in accordance with the publisher’s copyright policyDisordered eating (DE) is a widespread, serious problem. Efficacious prevention programs that can be delivered at-scale are needed.
A pragmatic randomized controlled trial of two online programs was conducted. Participants were young-adult women from Australia and New Zealand seeking to improve their body image. Media Smart-Targeted (MS-T) and Student Bodies (SB) were both 9-module interventions released weekly, whilst control participants received positive body image information. Primary [Eating Disorder Examination–Questionnaire (EDE-Q) Global], secondary (DE risk factors) and tertiary (DE) outcome measures were completed at baseline, post-program, 6- and 12-month follow-up.
Baseline was completed by 608 women (M age = 20.71 years); 33 were excluded leaving 575 randomized to: MS-T (N = 191); SB (N = 190) or control (N = 194). Only 66% of those randomized to MS-T or SB accessed the intervention and were included in analyses with controls; 78% of this sample completed measures subsequent to baseline. Primary intent-to-treat (ITT) analyses revealed no differences between groups, while measure completer analyses found MS-T had significantly lower EDE-Q Global than controls at 12-month follow-up. Secondary ITT analyses found MS-T participants reported significantly higher quality of life–mental relative to both SB and controls (6-month follow-up), while MS-T and controls had lower clinical impairment relative to SB (post-program). Amongst measure completers, MS-T scored significantly lower than controls and SB on 5 variables. Of those with baseline DE, MS-T participants were significantly less likely than controls to have DE at 12-month follow-up.
Given both programs were not therapist-moderated, MS-T has potential to achieve reductions in DE risk at low implementation costs
Optimal classical-communication-assisted local model of n-qubit Greenberger-Horne-Zeilinger correlations
We present a model, motivated by the criterion of reality put forward by
Einstein, Podolsky, and Rosen and supplemented by classical communication,
which correctly reproduces the quantum-mechanical predictions for measurements
of all products of Pauli operators on an n-qubit GHZ state (or ``cat state'').
The n-2 bits employed by our model are shown to be optimal for the allowed set
of measurements, demonstrating that the required communication overhead scales
linearly with n. We formulate a connection between the generation of the local
values utilized by our model and the stabilizer formalism, which leads us to
conjecture that a generalization of this method will shed light on the content
of the Gottesman-Knill theorem.Comment: New version - expanded and revised to address referee comment
Marine Monitoring Program. Final report of JCU activities 2012/13: flood plumes and extreme weather monitoring for the Great Barrier Reef Marine Park Authority
The Reef Rescue Marine Monitoring Program (MMP) undertaken in the Great Barrier Reef lagoon assesses the long-term effectiveness of the Australian and Queensland Government’s Reef Water Quality Protection Plan and the Australian Government Reef Rescue initiative. The MMP was established in 2005 to help assess the long-term status and health of Reef ecosystems and is a critical component in the assessment of regional water quality as land management practices are improved across Reef catchments. The program forms an integral part of the Reef Plan Paddock to Reef Integrated Monitoring, Modelling and Reporting Program supported through Reef Plan and Reef Rescue initiatives. This report details the sampling that has taken place under the Reef Rescue Marine Monitoring Program: Terrestrial discharge into the Great Barrier Reef for the 2012/13 sampling year.Report No. 15/5
The zebrafish eye—a paradigm for investigating human ocular genetics
Although human epidemiological and genetic studies are essential to elucidate the aetiology of normal and aberrant ocular development, animal models have provided us with an understanding of the pathogenesis of multiple developmental ocular malformations. Zebrafish eye development displays in depth molecular complexity and stringent spatiotemporal regulation that incorporates developmental contributions of the surface ectoderm, neuroectoderm and head mesenchyme, similar to that seen in humans. For this reason, and due to its genetic tractability, external fertilisation, and early optical clarity, the zebrafish has become an invaluable vertebrate system to investigate human ocular development and disease. Recently, zebrafish have been at the leading edge of preclinical therapy development, with their amenability to genetic manipulation facilitating the generation of robust ocular disease models required for large-scale genetic and drug screening programmes. This review presents an overview of human and zebrafish ocular development, genetic methodologies employed for zebrafish mutagenesis, relevant models of ocular disease, and finally therapeutic approaches, which may have translational leads in the future.Eye advance online publication, 9 September 2016; doi:10.1038/eye.2016.198
Annual report for flood plumes and extreme weather 2013-2014
The Marine Monitoring Program (MMP) undertaken in the Great Barrier Reef lagoon assesses the long-term effectiveness of the Australian and Queensland Government’s Reef Water Quality Protection Plan and the Australian Government Reef Rescue initiative. The MMP was established in 2005 to help assess the long-term status and health of Reef ecosystems and is a critical component in the assessment of regional water quality as land management practices are improved across Reef catchments. The program forms an integral part of the Reef Plan Paddock to Reef Integrated Monitoring, Modelling and Reporting Program supported through Reef Plan and Reef Rescue initiatives. This report details the sampling that has taken place under the Marine Monitoring Program: Annual report for flood plumes and extreme weather 2013-201
Safety Profile of Stromal Hydration of Clear Corneal Incisions with Cefuroxime in the Mouse Model
PURPOSE: The use of sutureless clear corneal incisions (CCIs) for phacoemulsification is an established surgical technique, but the dynamic morphology of the wound and poor construction can lead to an increased risk of postoperative endophthalmitis. Stromal hydration with balanced salt solution (BSS) can improve the self-sealing status. Intracameral cefuroxime has reduced endophthalmitis rates. This study investigates the safety profile of stromal hydration with cefuroxime, as sequestering antibiotic at the wound may potentially provide added protection against infection. METHODS: MF-1 mice underwent bilateral CCI, followed by stromal hydration with 5 μL of 10 mg/mL cefuroxime, cefuroxime-texas red conjugate (for detection using confocal microscopy), or BSS. Corneas were harvested from 1 h to 12 weeks postoperatively; gross morphology, histology, and apoptotic cell death levels were investigated to determine the safety profile. Bactericidal activity of cefuroxime was assayed using homogenized whole cornea following stromal hydration at 1 h, 24 h, and day 7 against gram-negative Escherichia coli. RESULTS: Cefuroxime stromal hydration did not alter corneal morphology, with no evidence of corneal scarring or vascularization. Corneal histology and levels of apoptosis were minimal and comparable to the BSS groups up to 12 weeks. Confocal microscopy detected cefuroxime-texas red up to 1 week surrounding the corneal wound. Whole corneal tissue homogenates displayed bactericidal activity up to 24 h postoperatively. CONCLUSIONS: Stromal hydration of CCI with cefuroxime is safe in mouse corneas. A reservoir of antibiotic at the wound can potentially act as a barrier of defense against infection following cataract and associated ocular surgery
The Three-Dimensional Structure of Cassiopeia A
We used the Spitzer Space Telescope's Infrared Spectrograph to map nearly the
entire extent of Cassiopeia A between 5-40 micron. Using infrared and Chandra
X-ray Doppler velocity measurements, along with the locations of optical ejecta
beyond the forward shock, we constructed a 3-D model of the remnant. The
structure of Cas A can be characterized into a spherical component, a tilted
thick disk, and multiple ejecta jets/pistons and optical fast-moving knots all
populating the thick disk plane. The Bright Ring in Cas A identifies the
intersection between the thick plane/pistons and a roughly spherical reverse
shock. The ejecta pistons indicate a radial velocity gradient in the explosion.
Some ejecta pistons are bipolar with oppositely-directed flows about the
expansion center while some ejecta pistons show no such symmetry. Some ejecta
pistons appear to maintain the integrity of the nuclear burning layers while
others appear to have punched through the outer layers. The ejecta pistons
indicate a radial velocity gradient in the explosion. In 3-D, the Fe jet in the
southeast occupies a "hole" in the Si-group emission and does not represent
"overturning", as previously thought. Although interaction with the
circumstellar medium affects the detailed appearance of the remnant and may
affect the visibility of the southeast Fe jet, the bulk of the symmetries and
asymmetries in Cas A are intrinsic to the explosion.Comment: Accepted to ApJ. 54 pages, 21 figures. For high resolution figures
and associated mpeg movie and 3D PDF files, see
http://homepages.spa.umn.edu/~tdelaney/pape
Improving the measurement of QALYs in dementia: developing patient- and carer-reported health state classification systems using Rasch analysis
Objectives: Cost-utility analysis is increasingly used to inform resource allocation. This requires a means of valuing health states before and after intervention. Although generic measures are typically used to generate values, these do not perform well with people with dementia. We report the development of a health state classification system amenable to valuation for use in studies of dementia, derived from the DEMQOL system, a measure of health-related quality of life in dementia by patient self-report (DEMQOL) and carer proxy-report (DEMQOL-Proxy). Methods: Factor analysis was used to determine the dimensional structure of DEMQOL and DEMQOL-Proxy. Rasch analysis was subsequently used to investigate item performance across factors in terms of item-level ordering, functioning across subgroups, model fit and severity-range coverage. This enabled the selection of one item from each factor for the classification system. A sample of people with a diagnosis of mild/moderate dementia (n=644) and a sample of carers of those with mild/moderate dementia (n=683) were used. Results: Factor analysis found different 5-factor solutions for DEMQOL and DEMQOL-Proxy. Following item reduction and selection using Rasch analysis, a 5-dimension classification for DEMQOL and a 4-dimension classification for DEMQOL-Proxy were developed. Each item contained 4 health state levels. Conclusion: Combining Rasch and classical psychometric analysis is a valid method of selecting items for dementia health state classifications from both the patient and carer perspectives. The next stage is to obtain preference weights so that the measure can be used in the economic evaluation of treatment, care and support arrangements for dementia.quality adjusted life years; health related quality of life; Rasch analysis; preference-based measures of health; health states; dementia
Design of a high efficiency cyclone for collection of rare and low concentration airborne pathogens
Recent serious outbreaks of pathogens such as Chalara Fraxinea, (Ash Dieback) demonstrate the vulnerability of UK’s forests, woods, and trees. Early detection of threats is critical in the fight against such tree pests and pathogens. This requires a process for collecting and analysing the spores which is robust, flexible and can be deployed rapidly, but which also has sufficient sensitivity to detect the earliest precursors. The work presented here describes a newly-developed high-efficiency detection apparatus and is part of an ongoing BBRSC project to improve the UK’s biosecurity. Our automatic spore system is capable of collecting and analysing Chalara Fraxinea using a novel cyclonic pathogen collector. Cyclones are an effective way to separate small particles (spores) from large quantities of surrounding air and store them for analysis. Our system incorporates a purpose-designed high efficiency cyclone directly integrated with a low power custom impeller to maximise volumetric air sampling while minimising the power requirement. 3D printing was used extensively to validate theoretical models and the particle collection and retention capability of this series of prototypes was evaluated experimentally within our Aerosol test chamber. We found that we could collect greater than 90% of particulate in the target size range, thus providing a front-end to a detection platform. Our system is capable of operating autonomously and at low power, with a high sensitivity to ambient particles. The final system design incorporates the use of multiple cyclone storage vessels ensuring complete isolation of each sample, eradicating cross-contamination, and facilitating automated handling of the sample inside the same apparatus. COTS – commercial off the shelf components were incorporated into the cyclone to make a series of cost effective collection vessels. Early collection and detection of pathogens in-situ represents a considerable advance in surveillance and monitoring of pathogens strengthening UK biosecurity for the future
- …