Imaging bedrock topography and geological controls on ice streams flowing in the Wilkes Subglacial Basin sector of East Antarctica

The northern Wilkes Subglacial Basin (NWSB) in East Antarctica underlies the catchments of the Matusevich, Cook, Ninnis and Mertz Glaciers, which are largely marine-based and hence particularly sensitive to past and future ocean and climate warming. Here we use airborne radar, aeromagnetic and airborne gravity data to image bedrock topography, subglacial geology and deeper crustal structure and assess its influence on ice sheet dynamics in the NWSB. The previously identified Central Basins extend beneath the fast flowing Cook ice streams, indicating that potential ocean-induced changes could propagate further into the interior of the ice sheet. By analogy with the better exposed Rennick Graben in northern Victoria Land, these deep subglacial basins are interpreted here as grabens that steer fast glacial flow. With the aid of depth to source estimates and forward magnetic and gravity models, we image the 3D variability in geological basal boundary conditions, including Beacon sediments and Jurassic basaltic rocks and uplifted basement blocks within and along the flanks of these grabens. A remarkable contrast in magnetic anomaly signatures is observed over the coastal and inland segments of the Cook ice stream catchment. We model several km thick early Cambrian to late Neoproterozoic sedimentary basins in the basement of the coastal region, in contrast to a prominent Proterozoic basement high at the onset of fast glacial flow further inland. We further hypothesise that this difference affects geothermal heat flux at the base of the ice sheet, which could in turn influence basal melting and subglacial hydrology

Topology and energy transport in networks of interacting photosynthetic complexes

We address the role of topology in the energy transport process that occurs in networks of photosynthetic complexes. We take inspiration from light harvesting networks present in purple bacteria and simulate an incoherent dissipative energy transport process on more general and abstract networks, considering both regular structures (Cayley trees and hyperbranched fractals) and randomly-generated ones. We focus on the the two primary light harvesting complexes of purple bacteria, i.e., the LH1 and LH2, and we use network-theoretical centrality measures in order to select different LH1 arrangements. We show that different choices cause significant differences in the transport efficiencies, and that for regular networks centrality measures allow to identify arrangements that ensure transport efficiencies which are better than those obtained with a random disposition of the complexes. The optimal arrangements strongly depend on the dissipative nature of the dynamics and on the topological properties of the networks considered, and depending on the latter they are achieved by using global vs. local centrality measures. For randomly-generated networks a random arrangement of the complexes already provides efficient transport, and this suggests the process is strong with respect to limited amount of control in the structure design and to the disorder inherent in the construction of randomly-assembled structures. Finally, we compare the networks considered with the real biological networks and find that the latter have in general better performances, due to their higher connectivity, but the former with optimal arrangements can mimic the real networks' behaviour for a specific range of transport parameters. These results show that the use of network-theoretical concepts can be crucial for the characterization and design of efficient artificial energy transport networks.Comment: 14 pages, 16 figures, revised versio

Massive transfusion protocol optimization

Hemorrhage is the leading cause of mortality in trauma, accounting for up to 80% of intraoperative trauma mortalities and nearly half of the deaths that occur within 24 hours of traumatic injury. The timely and appropriate administration of blood products in hemorrhage control is paramount to adequate resuscitation efforts. Given the need for rapid delivery of products, appropriate product infusion ratios, and adjunctive therapies for control of hemorrhage and anticoagulation reversal, it is essential that facilities have and maintain a Massive Transfusion Protocol. The goal of this project was to create a Massive Transfusion Protocol for our facility that incorporated current literature, involved buy-in from all involved departments, and optimized blood product ordering and delivery in the emergency setting. To this end, a literature search was performed, and a protocol was drafted which focused on single entry point ordering, and automated product delivery until massive transfusion was halted. Elective orders were also incorporated for easy requesting of coagulation reversal agents and pro-clotting factors. The final draft of the protocol was submitted to the hospital transfusion committee for approval and then incorporated into an EHR order set. Staff training was performed in all involved departments before deployment. Outcome measurement is ongoing but it is anticipated that this updated protocol will decrease time between disposition of major bleed and arrival of blood products at the bedside. It is also expected that this protocol will decrease the amount of crystalloid products given to major bleeding patients by increasing efficiency of blood product delivery

Filamentation Involves Two Overlapping, but Distinct, Programs of Filamentation in the Pathogenic Fungus Candida albicans

The ability of the human pathogenic fungus Candida albicans to switch between yeast-like and filamentous forms of growth has long been linked to pathogenesis. Numerous environmental conditions, including growth at high temperatures, nutrient limitation, and exposure to serum, can trigger this morphological switch and are frequently used in in vitro models to identify genes with roles in filamentation. Previous work has suggested that differences exist between the various in vitro models both in the genetic requirements for filamentation and transcriptional responses to distinct filamentation-inducing media, but these differences had not been analyzed in detail. We compared 10 in vitro models for filamentation and found broad genetic and transcriptomic differences between model systems. The comparative analysis enabled the discovery of novel media-independent genetic requirements for filamentation as well as a core filamentation transcriptional profile. Our data also suggest that the physical environment drives distinct programs of filamentation in C. albicans, which has significant implications for filamentation in vivo

Airborne gravity and precise positioning for geologic applications

Airborne gravimetry has become an important geophysical tool primarily because of advancements in methodology and instrumentation made in the past decade. Airborne gravity is especially useful when measured in conjunction with other geophysical data, such as magnetics, radar, and laser altimetry. The aerogeophysical survey over the West Antarctic ice sheet described in this paper is one such interdisciplinary study. This paper outlines in detail the instrumentation, survey and data processing methodology employed to perform airborne gravimetry from the multiinstrumented Twin Otter aircraft. Precise positioning from carrier-phase Global Positioning System (GPS) observations are combined with measurements of acceleration made by the gravity meter in the aircraft to obtain the free-air gravity anomaly measurement at aircraft altitude. GPS data are processed using the Kinematic and Rapid Static (KARS) software program, and aircraft vertical acceleration and corrections for gravity data reduction are calculated from the GPS position solution. Accuracies for the free-air anomaly are determined from crossover analysis after significant editing (2.98 mGal rms) and from a repeat track (1.39 mGal rms). The aerogeophysical survey covered a 300,000 km2 region in West Antarctica over the course of five field seasons. The gravity data from the West Antarctic survey reveal the major geologic structures of the West Antarctic rift system, including the Whitmore Mountains, the Byrd Subglacial Basin, the Sinuous Ridge, the Ross Embayment, and Siple Dome. These measurements, in conjunction with magnetics and ice-penetrating radar, provide the information required to reveal the tectonic fabric and history of this important region

Dose–Response Relationships of Clothianidin, Imidacloprid, and Thiamethoxam to \u3ci\u3eBlissus occiduus\u3c/i\u3e (Hemiptera: Blissidae)

The western chinch bug, Blissus occiduus Barber (Hemiptera: Blissidae), has emerged as a serious pest of buffalograss, Buchloë dactyloides (Nuttall) Engelmann. In general, neonicotinoid insecticides effectively control a variety of turfgrass insects, particularly phloem-feeding pests. However, because of well documented inconsistencies in control, these compounds are generally not recommended for chinch bugs. This study was designed to document the contact and systemic toxicity of three neonicotinoid insecticides (clothianidin, imidacloprid, and thiamethoxam) to B. occiduus. In contact bioassays, thiamethoxam was ~20-fold less toxic than clothianidin or imidacloprid to B. occiduus nymphs and three-fold more toxic to adults. In adult systemic bioassays, thiamethoxam was up to five-fold more toxic than clothianidin or imidacloprid. Interestingly, thiamethoxam was significantly more toxic to adults than to nymphs in both contact and systemic bioassays. This was not observed with clothianidin or imidacloprid. Bifenthrin, used for comparative purposes, exhibited 1,844-fold and 122-fold increase in toxicity to nymphs and adults, respectively. These results provide the first documentation of the relative toxicity of these neonicotinoid insecticides to B. occiduus

Elastic Angular Differential Cross Sections for Quasi-One-Electron Collision Systems at Intermediate Energies: (Na⁺, Li⁺)+H and (Mg⁺, Be⁺)+He

Measurements of elastic angular differential cross sections have been carried out for four quasi-one-electron collision systems at intermediate energies. Data are presented for Na++H collisions at laboratory energies of 35.94, 51.75, 63.89, and 143.75 keV, for Li++H collisions at energies of 19.44 and 43.75 keV, for Mg++He collisions at energies of 30, 66.7, and 150 keV, and for Be++He collisions at an energy of 56.25 keV. The highest energy in each case corresponds to a projectile velocity of (1/2 a.u. Born and Eikonal calculations, in which we model the projectile ion as a heavy structureless ion of charge +1e, are also presented. Our model calculations are in fair agreement with the experimental data over the range of measured scattering angles

Angular-Differential Studies of Excitation in Quasi-One-Electron Collisions at High Energy

Qualitative differences have been observed between two types of quasi-one-electron collision systems. We have studied valence-electron excitation at high energy (relative collision velocities up to 0.5 a.u.) in the Mg++He and Na++H collision systems, and find that while Mg++He collisions are dominated by direct excitation, the Na++H collisions exhibit significant molecular excitation, even at the highest velocities. This behavior can be understood in terms of the molecular structure of the respective collision complexes, and the energy separation between the ground and first excited states of the valence electron