307 research outputs found
Measurements of integral muon intensity at large zenith angles
High-statistics data on near-horizontal muons collected with Russian-Italian
coordinate detector DECOR are analyzed. Precise measurements of muon angular
distributions in zenith angle interval from 60 to 90 degrees have been
performed. In total, more than 20 million muons are selected. Dependences of
the absolute integral muon intensity on zenith angle for several threshold
energies ranging from 1.7 GeV to 7.2 GeV are derived. Results for this region
of zenith angles and threshold energies have been obtained for the first time.
The dependence of integral intensity on zenith angle and threshold energy is
well fitted by a simple analytical formula.Comment: 4 pages, 4 figures, 1 tabl
Statistical features of edge turbulence in RFX-mod from Gas Puffing Imaging
Plasma density fluctuations in the edge plasma of the RFX-mod device are
measured through the Gas Puffing Imaging Diagnostics. Statistical features of
the signal are quantified in terms of the Probability Distribution Function
(PDF), and computed for several kinds of discharges. The PDFs from discharges
without particular control methods are found to be adequately described by a
Gamma function, consistently with the recent results by Graves et al [J.P.
Graves, et al, Plasma Phys. Control. Fusion 47, L1 (2005)]. On the other hand,
pulses with external methods for plasma control feature modified PDFs. A first
empirical analysis suggests that they may be interpolated through a linear
combination of simple functions. An inspection of the literature shows that
this kind of PDFs is common to other devices as well, and has been suggested to
be due to the simultaneous presence of different mechanisms driving
respectively coherent bursts and gaussian background turbulence. An attempt is
made to relate differences in the PDFs to plasma conditions such as the local
shift of the plasma column. A simple phenomenological model to interpret the
nature of the PDF and assign a meaning to its parameters is also developed.Comment: 27 pages. Published in PPC
Intensity distribution for waves in disordered media: deviations from Rayleigh statistics
We study the intensity distribution function, P(I), for monochromatic waves
propagating in quasi one-dimensional disordered medium, assuming that a point
source and a point detector are embedded in the bulk of the medium. We find
deviations from the Rayleigh statistics at moderately large I and a
logarithmically-normal asymptotic behavior of P(I). When the radiation source
and the detector are located close to the opposite edges of the sample (on a
distance much less then the sample length), an intermediate regime with a
stretched-exponential behavior of P(I) emerges.Comment: 4 pages Revtex, 3 figures included as eps file
Toward Global Quantum Communication: Beam Wandering Preserves Nonclassicality
Tap-proof long-distance quantum communication requires a deep understanding
of the strong losses in transmission channels. Here we provide a rigorous
treatment of the effects of beam wandering, one of the leading disturbances in
atmospheric channels, on the quantum properties of light. From first principles
we derive the probability distribution of the beam transmissivity, with the aim
to completely characterize the quantum state of light. It turns out that beam
wandering may preserve nonclassical effects, such as entanglement, quadrature
and photon number squeezing, much better than a standard attenuating channel of
the same losses.Comment: published versio
Modeling Water Quality in Watersheds: From Here to the Next Generation
In this synthesis, we assess present research and anticipate future development needs in modeling water quality in watersheds. We first discuss areas of potential improvement in the representation of freshwater systems pertaining to water quality, including representation of environmental interfaces, in-stream water quality and process interactions, soil health and land management, and (peri-)urban areas. In addition, we provide insights into the contemporary challenges in the practices of watershed water quality modeling, including quality control of monitoring data, model parameterization and calibration, uncertainty management, scale mismatches, and provisioning of modeling tools. Finally, we make three recommendations to provide a path forward for improving watershed water quality modeling science, infrastructure, and practices. These include building stronger collaborations between experimentalists and modelers, bridging gaps between modelers and stakeholders, and cultivating and applying procedural knowledge to better govern and support water quality modeling processes within organizations
Intermediate Tail Dependence: A Review and Some New Results
The concept of intermediate tail dependence is useful if one wants to
quantify the degree of positive dependence in the tails when there is no strong
evidence of presence of the usual tail dependence. We first review existing
studies on intermediate tail dependence, and then we report new results to
supplement the review. Intermediate tail dependence for elliptical, extreme
value and Archimedean copulas are reviewed and further studied, respectively.
For Archimedean copulas, we not only consider the frailty model but also the
recently studied scale mixture model; for the latter, conditions leading to
upper intermediate tail dependence are presented, and it provides a useful way
to simulate copulas with desirable intermediate tail dependence structures.Comment: 25 pages, 1 figur
Electrostatic potential in a superconductor
The electrostatic potential in a superconductor is studied. To this end
Bardeen's extension of the Ginzburg-Landau theory to low temperatures is used
to derive three Ginzburg-Landau equations - the Maxwell equation for the vector
potential, the Schroedinger equation for the wave function and the Poisson
equation for the electrostatic potential. The electrostatic and the
thermodynamic potential compensate each other to a great extent resulting into
an effective potential acting on the superconducting condensate. For the
Abrikosov vortex lattice in Niobium, numerical solutions are presented and the
different contributions to the electrostatic potential and the related charge
distribution are discussed.Comment: 19 pages, 11 figure
Immune-mediated competition in rodent malaria is most likely caused by induced changes in innate immune clearance of merozoites
Malarial infections are often genetically diverse, leading to competitive interactions between parasites. A quantitative understanding of the competition between strains is essential to understand a wide range of issues, including the evolution of virulence and drug resistance. In this study, we use dynamical-model based Bayesian inference to investigate the cause of competitive suppression of an avirulent clone of Plasmodium chabaudi (AS) by a virulent clone (AJ) in immuno-deficient and competent mice. We test whether competitive suppression is caused by clone-specific differences in one or more of the following processes: adaptive immune clearance of merozoites and parasitised red blood cells (RBCs), background loss of merozoites and parasitised RBCs, RBC age preference, RBC infection rate, burst size, and within-RBC interference. These processes were parameterised in dynamical mathematical models and fitted to experimental data. We found that just one parameter μ, the ratio of background loss rate of merozoites to invasion rate of mature RBCs, needed to be clone-specific to predict the data. Interestingly, μ was found to be the same for both clones in single-clone infections, but different between the clones in mixed infections. The size of this difference was largest in immuno-competent mice and smallest in immuno-deficient mice. This explains why competitive suppression was alleviated in immuno-deficient mice. We found that competitive suppression acts early in infection, even before the day of peak parasitaemia. These results lead us to argue that the innate immune response clearing merozoites is the most likely, but not necessarily the only, mediator of competitive interactions between virulent and avirulent clones. Moreover, in mixed infections we predict there to be an interaction between the clones and the innate immune response which induces changes in the strength of its clearance of merozoites. What this interaction is unknown, but future refinement of the model, challenged with other datasets, may lead to its discovery
Vascular endothelial growth factor (VEGF) upregulates BCL-2 and inhibits apoptosis in human and murine mammary adenocarcinoma cells
Tumour progression is regulated by the balance of proliferation and apoptosis in the tumour cell population. To date, the role of vascular endothelial growth factor (VEGF) in tumour growth has been attributed to the induction of angiogenesis. VEGF has been shown to be a survival factor for endothelial cells, preventing apoptosis by inducing Bcl-2 expression. In both murine (4T1) and human (MDA-MB-231) metastatic mammary carcinoma cell lines, we found that VEGF upregulated Bcl-2 expression and anti-VEGF antibodies reduced Bcl-2 expression. These alterations in Bcl-2 expression were reflected by the levels of tumour cell apoptosis. VEGF resulted in reduced tumour cell apoptosis, whereas its inhibition with anti-VEGF neutralizing antibodies induced apoptosis directly in tumour cells. Therefore, in addition to its role in angiogenesis and vessel permeability, VEGF acts as a survival factor for tumour cells, inducing Bcl-2 expression and inhibiting tumour cell apoptosis. © 2001 Cancer Research Campaign http://www.bjcancer.co
Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes
<p>Abstract</p> <p>Background</p> <p>GlnR is an atypical response regulator found in actinomycetes that modulates the transcription of genes in response to changes in nitrogen availability. We applied a global <it>in vivo </it>approach to identify the GlnR regulon of <it>Streptomyces venezuelae</it>, which, unlike many actinomycetes, grows in a diffuse manner that is suitable for physiological studies. Conditions were defined that facilitated analysis of GlnR-dependent induction of gene expression in response to rapid nitrogen starvation. Microarray analysis identified global transcriptional differences between <it>glnR</it><sup>+ </sup>and <it>glnR </it>mutant strains under varying nitrogen conditions. To differentiate between direct and indirect regulatory effects of GlnR, chromatin immuno-precipitation (ChIP) using antibodies specific to a FLAG-tagged GlnR protein, coupled with microarray analysis (ChIP-chip), was used to identify GlnR binding sites throughout the <it>S. venezuelae </it>genome.</p> <p>Results</p> <p>GlnR bound to its target sites in both transcriptionally active and apparently inactive forms. Thirty-six GlnR binding sites were identified by ChIP-chip analysis allowing derivation of a consensus GlnR-binding site for <it>S. venezuelae</it>. GlnR-binding regions were associated with genes involved in primary nitrogen metabolism, secondary metabolism, the synthesis of catabolic enzymes and a number of transport-related functions.</p> <p>Conclusions</p> <p>The GlnR regulon of <it>S. venezuelae </it>is extensive and impacts on many facets of the organism's biology. GlnR can apparently bind to its target sites in both transcriptionally active and inactive forms.</p
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