360 research outputs found
Emergent Properties of Tumor Microenvironment in a Real-life Model of Multicell Tumor Spheroids
Multicellular tumor spheroids are an important {\it in vitro} model of the
pre-vascular phase of solid tumors, for sizes well below the diagnostic limit:
therefore a biophysical model of spheroids has the ability to shed light on the
internal workings and organization of tumors at a critical phase of their
development. To this end, we have developed a computer program that integrates
the behavior of individual cells and their interactions with other cells and
the surrounding environment. It is based on a quantitative description of
metabolism, growth, proliferation and death of single tumor cells, and on
equations that model biochemical and mechanical cell-cell and cell-environment
interactions. The program reproduces existing experimental data on spheroids,
and yields unique views of their microenvironment. Simulations show complex
internal flows and motions of nutrients, metabolites and cells, that are
otherwise unobservable with current experimental techniques, and give novel
clues on tumor development and strong hints for future therapies.Comment: 20 pages, 10 figures. Accepted for publication in PLOS One. The
published version contains links to a supplementary text and three video
file
Signal yields, energy resolution, and recombination fluctuations in liquid xenon
This work presents an analysis of monoenergetic electronic recoil peaks in
the dark-matter-search and calibration data from the first underground science
run of the Large Underground Xenon (LUX) detector. Liquid xenon charge and
light yields for electronic recoil energies between 5.2 and 661.7 keV are
measured, as well as the energy resolution for the LUX detector at those same
energies. Additionally, there is an interpretation of existing measurements and
descriptions of electron-ion recombination fluctuations in liquid xenon as
limiting cases of a more general liquid xenon re- combination fluctuation
model. Measurements of the standard deviation of these fluctuations at
monoenergetic electronic recoil peaks exhibit a linear dependence on the number
of ions for energy deposits up to 661.7 keV, consistent with previous LUX
measurements between 2-16 keV with H. We highlight similarities in liquid
xenon recombination for electronic and nuclear recoils with a comparison of
recombination fluctuations measured with low-energy calibration data.Comment: 11 pages, 12 figures, 3 table
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