6,522 research outputs found
Phenology satellite experiment
The detection of a phenological event (the brown wave-vegetation senescence) for specific forest and crop types using ERTS-1 imagery is described. Data handling techniques included computer analysis and photo interpretation procedures. Computer analysis of ERTS-1 multispectral scanner digital tapes in all bands was used to give the relative changes of spectral reflectance with time of forests and specified crops. These data were obtained for a number of the study's twenty-four sites located within four north-south corridors across the United States. Analysis of ground observation photography and ERTS-1 imagery for sites in the Appalachian Corridor and Mississippi Valley Corridor indicates that the recession of vegetation development can be detected very well. Tentative conclusions are that specific phenological events such as crop maturity or leaf fall can be mapped for specific sites and possibly for entire regions
Evidence for bimodal orbital separations of white dwarf-red dwarf binary stars
We present the results of a radial velocity survey of 20 white dwarf plus M
dwarf binaries selected as a follow up to a \textit{Hubble Space Telescope}
study that aimed to spatially resolve suspected binaries. Our candidates are
taken from the list of targets that were spatially unresolved with
\textit{Hubble}. We have determined the orbital periods for 16 of these compact
binary candidates. The period distribution ranges from 0.14 to 9.16\,d and
peaks near 0.6\,d. The original sample therefore contains two sets of binaries,
wide orbits (\,au) and close orbits (\,au), with
no systems found in the \,au range. This observational evidence
confirms the bimodal distribution predicted by population models and is also
similar to results obtained in previous studies. We find no binary periods in
the months to years range, supporting the post common envelope evolution
scenario. One of our targets, WD\,1504+546, was discovered to be an eclipsing
binary with a period of 0.93\,d
Phenology satellite experiment
There are no author-identified significant results in this report
A Wide-Field CCD Survey for Centaurs and Kuiper Belt Objects
A modified Baker-Nunn camera was used to conduct a wide-field survey of 1428
square degrees of sky near the ecliptic in search of bright Kuiper Belt objects
and Centaurs. This area is an order of magnitude larger than any previously
published CCD survey for Centaurs and Kuiper Belt Objects. No new objects
brighter than red magnitude m=18.8 and moving at a rate 1"/hr to 20"/hr were
discovered, although one previously discovered Centaur 1997 CU26 Chariklo was
serendipitously detected. The parameters of the survey were characterized using
both visual and automated techniques. From this survey the empirical projected
surface density of Centaurs was found to be SigmaCentaur(m<18.8)=7.8(+16.0
-6.6)x10^-4 per square degree and we found a projected surface density 3sigma
upper confidence limit for Kuiper Belt objects of SigmaKBO(m< 18.8)<4.1x10^-3
per square degree. We discuss the current state of the cumulative luminosity
functions of both Centaurs and Kuiper Belt objects. Through a Monte Carlo
simulation we show that the size distribution of Centaurs is consistent with a
q=4 differential power law, similar to the size distribution of the parent
Kuiper Belt Objects. The Centaur population is of order 10^7 (radius > 1 km)
assuming a geometric albedo of 0.04. About 100 Centaurs are larger than 50 km
in radius, of which only 4 are presently known. The current total mass of the
Centaurs is 10^-4 Earth Masses. No dust clouds were detected resulting from
Kuiper Belt object collisions, placing a 3sigma upper limit <600 collisionally
produced clouds of m<18.8 per year.Comment: 13 pages, 5 figures, Accepted for Publication in A
The first high-amplitude delta Scuti star in an eclipsing binary system
We report the discovery of the first high-amplitude delta Scuti star in an
eclipsing binary, which we have designated UNSW-V-500. The system is an
Algol-type semi-detached eclipsing binary of maximum brightness V = 12.52 mag.
A best-fitting solution to the binary light curve and two radial velocity
curves is derived using the Wilson-Devinney code. We identify a late A spectral
type primary component of mass 1.49+/-0.02 M_sun and a late K spectral type
secondary of mass 0.33+/-0.02 M_sun, with an inclination of 86.5+/-1.0 degrees,
and a period of 5.3504751+/-0.0000006 d. A Fourier analysis of the residuals
from this solution is performed using PERIOD04 to investigate the delta Scuti
pulsations. We detect a single pulsation frequency of f_1 = 13.621+/-0.015 c/d,
and it appears this is the first overtone radial mode frequency. This system
provides the first opportunity to measure the dynamical mass for a star of this
variable type; previously, masses have been derived from stellar evolution and
pulsation models.Comment: 7 pages, 6 figures, 2 tables, for submission to MNRAS, v2: paper size
change, small typographical changes to abstrac
Distinct phosphorylation clusters determines the signalling outcome of the free fatty acid receptor FFA4/GPR120
It is established that long-chain free fatty acids including ω-3 fatty acids mediate an array of biological responses through members of the free fatty acid receptor family, which includes FFA4. However, the signalling mechanisms and modes of regulation of this receptor class remain unclear. Here we employ mass spectrometry to determine that phosphorylation of mouse (m)FFAR4 occurs at five serine and threonine residues clustered in two separable regions of the C terminal tail, designated cluster 1 (Thr347, Thr349 and Ser350) and cluster 2 (Ser357 and Ser361). Mutation of these phospho-acceptor sites to alanine completely prevented phosphorylation of mFFA4 but did not limit receptor coupling to ERK1/2 activation. Rather an inhibitor of Gq/11 proteins completely prevented receptor signalling to ERK1/2. In contrast, the recruitment of arrestin 3, receptor internalization and activation of Akt were regulated by mFFA4 phosphorylation. The analysis of mFFA4 phosphorylation-dependent signalling was extended further by selective mutations of the phospho-acceptor sites. Mutations within cluster 2 did not affect agonist activation of Akt but instead significantly compromised receptor internalization and arrestin 3 recruitment. Distinctly, mutation of the phospho-acceptor sites within cluster 1 had no effect on receptor internalization and a less extensive effect on arrestin 3 recruitment, but significantly uncoupled the receptor from Akt activation. These unique observations define differential effects on signalling mediated by phosphorylation at distinct locations. This hallmark feature supports the possibility that the signalling outcome of mFFA4 activation can be determined by the pattern of phosphorylation (phosphorylation barcode) at the C-terminus of the receptor
Band anticrossing in GaNxSb1–x
Fourier transform infrared absorption measurements are presented from the dilute nitride semiconductor GaNSb with nitrogen incorporations between 0.2% and 1.0%. The divergence of transitions from the valence band to E– and E+ can be seen with increasing nitrogen incorporation, consistent with theoretical predictions. The GaNSb band structure has been modeled using a five-band k·p Hamiltonian and a band anticrossing fitting has been obtained using a nitrogen level of 0.78 eV above the valence band maximum and a coupling parameter of 2.6 eV
DNMT3b overexpression contributes to a hypermethylator phenotype in human breast cancer cell lines
<p>Abstract</p> <p>Background</p> <p>DNA hypermethylation events and other epimutations occur in many neoplasms, producing gene expression changes that contribute to neoplastic transformation, tumorigenesis, and tumor behavior. Some human cancers exhibit a hypermethylator phenotype, characterized by concurrent DNA methylation-dependent silencing of multiple genes. To determine if a hypermethylation defect occurs in breast cancer, the expression profile and promoter methylation status of methylation-sensitive genes were evaluated among breast cancer cell lines.</p> <p>Results</p> <p>The relationship between gene expression (assessed by RT-PCR and quantitative real-time PCR), promoter methylation (assessed by methylation-specific PCR, bisulfite sequencing, and 5-aza-2'deoxycytidine treatment), and the DNA methyltransferase machinery (total DNMT activity and expression of DNMT1, DNMT3a, and DNMT3b proteins) were examined in 12 breast cancer cell lines. Unsupervised cluster analysis of the expression of 64 methylation-sensitive genes revealed two groups of cell lines that possess distinct methylation signatures: (i) hypermethylator cell lines, and (ii) low-frequency methylator cell lines. The hypermethylator cell lines are characterized by high rates of concurrent methylation of six genes (<it>CDH1, CEACAM6, CST6, ESR1, LCN2, SCNN1A</it>), whereas the low-frequency methylator cell lines do not methylate these genes. Hypermethylator cell lines coordinately overexpress total DNMT activity and DNMT3b protein levels compared to normal breast epithelial cells. In contrast, most low-frequency methylator cell lines possess DNMT activity and protein levels that are indistinguishable from normal. Microarray data mining identified a strong cluster of primary breast tumors that express the hypermethylation signature defined by <it>CDH1</it>, <it>CEACAM6, CST6, ESR1, LCN2</it>, and <it>SCNN1A</it>. This subset of breast cancers represents 18/88 (20%) tumors in the dataset analyzed, and 100% of these tumors were classified as basal-like, suggesting that the hypermethylator defect cosegregates with poor prognosis breast cancers.</p> <p>Conclusion</p> <p>These observations combine to strongly suggest that: (a) a subset of breast cancer cell lines express a hypermethylator phenotype, (b) the hypermethylation defect in these breast cancer cell lines is related to aberrant overexpression of DNMT activity, (c) overexpression of DNMT3b protein significantly contributes to the elevated DNMT activity observed in tumor cells expressing this phenotype, and (d) the six-gene hypermethylator signature characterized in breast cancer cell lines defines a distinct cluster of primary basal-like breast cancers.</p
Band gap reduction in GaNSb alloys due to the anion mismatch
The structural and optoelectronic properties in GaNxSb1–x alloys (0<=x<0.02) grown by molecular-beam epitaxy on both GaSb substrates and AlSb buffer layers on GaAs substrates are investigated. High-resolution x-ray diffraction (XRD) and reciprocal space mapping indicate that the GaNxSb1–x epilayers are of high crystalline quality and the alloy composition is found to be independent of substrate, for identical growth conditions. The band gap of the GaNSb alloys is found to decrease with increasing nitrogen content from absorption spectroscopy. Strain-induced band-gap shifts, Moss-Burstein effects, and band renormalization were ruled out by XRD and Hall measurements. The band-gap reduction is solely due to the substitution of dilute amounts of highly electronegative nitrogen for antimony, and is greater than observed in GaNAs with the same N content
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