28 research outputs found
ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ°ΠΊΡΠΎΡΠ° Π²ΠΎΠ΄ΠΈΡΠ΅Π»Ρ Π½Π° ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΠΎΠ³ΠΎ Π·Π°ΡΠΎΡΠ°
Driving in a traffic flow implies involvement in difficult traffic situations that adversely affects response time of a driver, which in turn is considered when estimating stopping distance of a vehicle and determines road safety. This relationship shows the effect of driver behaviour in traffic flow on the road traffic situation. The objective of the study was to study behavioural factors that influence driverβs decisions. The study used methods of driver behaviour modelling, mathematical modelling, experimental studies of the mental and psychological functions of drivers. Modelling the driverβs behaviour, considering various combinations of many behavioural and other factors, leads to a large number of options for mathematical description of driver behaviour, which makes it difficult to use this approach to describe behaviour of drivers under the conditions of a real street-road network. The research has analysed several works devoted to the study of control action of drivers, using unknown coefficients, describing a model of movement of vehicles considering accuracy of their control. Driving through an unregulated intersection is considered as the most complex and informative version of driverβs behaviour. It is found that when modelling a traffic flow, it is necessary to take into account the degree of resoluteness of drivers (through determination of a coefficient of resoluteness which is a random variable that takes into account the probability distribution of the coefficientβs value in conjunction with the probability distribution of the function of traffic flow intensity). The distribution of the coefficient of resoluteness of drivers, obtained from experimental data, was subject to analysis. It is determined that the driving style affects formation of traffic congestion. The assessment of the driving style is made through conditional classification of driver behaviour on the road, namely marked by manifestation of aggression and timidity. When studying the behaviour of timid and aggressive drivers, several pairs of trajectories and the dynamics of the corresponding traffic flow density, were considered and calculated based on Edieβs model. It has been confirmed that traffic congestion has the greatest negative effect on choleric drivers and sanguine drivers. Besides, there is a relationship between the response time of a driver and the change in his functional condition. It is concluded that to improve road safety thanks to a more accurate assessment of possible risks of formation of congestion situations, it is necessary to consider behavioural characteristics and temperaments of the drivers.ΠΠ²ΠΈΠΆΠ΅Π½ΠΈΠ΅ Π²Π°Π²ΡΠΎΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΠΎΠΌ ΠΏΠΎΡΠΎΠΊΠ΅ ΠΏΠΎΠ΄ΡΠ°Π·ΡΠΌΠ΅Π²Π°Π΅Ρ Π²ΠΎΠ²Π»Π΅ΡΠ΅Π½ΠΈΠ΅ Π² ΡΠ»ΠΎΠΆΠ½ΡΠ΅ Π΄ΠΎΡΠΎΠΆΠ½ΡΠ΅ ΡΠΈΡΡΠ°ΡΠΈΠΈ, ΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΠΎ Π²Π»ΠΈΡΡΡΠΈΠ΅ Π½Π° Π²ΡΠ΅ΠΌΡ ΡΠ΅Π°ΠΊΡΠΈΠΈ Π²ΠΎΠ΄ΠΈΡΠ΅Π»Ρ, ΠΊΠΎΡΠΎΡΠ°Ρ Π² ΡΠ²ΠΎΡ ΠΎΡΠ΅ΡΠ΅Π΄Ρ ΡΡΠΈΡΡΠ²Π°Π΅ΡΡΡ ΠΏΡΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠΈ ΡΠΎΡΠΌΠΎΠ·Π½ΠΎΠ³ΠΎ ΠΏΡΡΠΈ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΠΎΠ³ΠΎ ΡΡΠ΅Π΄ΡΡΠ²Π° ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅Ρ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΡ Π΄ΠΎΡΠΎΠΆΠ½ΠΎΠ³ΠΎ Π΄Π²ΠΈΠΆΠ΅Π½ΠΈΡ. ΠΡΠ° Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Ρ ΠΏΠΎΠΊΠ°Π·ΡΠ²Π°Π΅Ρ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π²ΠΎΠ΄ΠΈΡΠ΅Π»Π΅ΠΉ Π² ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΠΎΠΌ ΠΏΠΎΡΠΎΠΊΠ΅ Π½Π° Π΄ΠΎΡΠΎΠΆΠ½ΠΎΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΡΡ ΡΠΈΡΡΠ°ΡΠΈΡ. Π¦Π΅Π»ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π±ΡΠ»ΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΡΠ΅ΡΠΊΠΈΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ², Π²Π»ΠΈΡΡΡΠΈΡ
Π½Π° ΠΏΡΠΈΠ½ΡΡΠΈΠ΅ Π²ΠΎΠ΄ΠΈΡΠ΅Π»ΡΠΌΠΈ ΡΠ΅ΡΠ΅Π½ΠΈΠΉ. Π Ρ
ΠΎΠ΄Π΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π²ΠΎΠ΄ΠΈΡΠ΅Π»Π΅ΠΉ, ΠΌΠ°ΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ, ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΈΡ
ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ ΠΏΡΠΈΡ
ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ½ΠΊΡΠΈΠΉ Π²ΠΎΠ΄ΠΈΡΠ΅Π»Π΅ΠΉ. ΠΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π²ΠΎΠ΄ΠΈΡΠ΅Π»Ρ Ρ ΡΡΡΡΠΎΠΌ ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΡ ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²Π° ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΡΠ΅ΡΠΊΠΈΡ
ΠΈ ΠΈΠ½ΡΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ Π±ΠΎΠ»ΡΡΠΎΠΌΡ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Ρ Π²Π°ΡΠΈΠ°Π½ΡΠΎΠ² ΠΌΠ°ΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠΏΠΈΡΠ°Π½ΠΈΡ ΡΠ°ΠΊΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ, ΡΡΠΎ Π·Π°ΡΡΡΠ΄Π½ΡΠ΅Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Π° ΠΏΡΠΈ ΠΎΠΏΠΈΡΠ°Π½ΠΈΠΈ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π²ΠΎΠ΄ΠΈΡΠ΅Π»Π΅ΠΉ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΡΠ΅Π°Π»ΡΠ½ΠΎΠΉ ΡΠ»ΠΈΡΠ½ΠΎ-Π΄ΠΎΡΠΎΠΆΠ½ΠΎΠΉ ΡΠ΅ΡΠΈ. ΠΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΡΠ°Π±ΠΎΡΡ, ΠΏΠΎΡΠ²ΡΡΡΠ½Π½ΡΠ΅ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΡΠΏΡΠ°Π²Π»ΡΡΡΠ΅Π³ΠΎ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π²ΠΎΠ΄ΠΈΡΠ΅Π»Ρ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π½Π΅ΠΈΠ·Π²Π΅ΡΡΠ½ΡΡ
ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΠΎΠ², ΠΎΠΏΠΈΡΡΠ²Π°ΡΡΠΈΡ
ΠΌΠΎΠ΄Π΅Π»Ρ Π΄Π²ΠΈΠΆΠ΅Π½ΠΈΡ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΡΡ
ΡΡΠ΅Π΄ΡΡΠ² Ρ ΡΡΡΡΠΎΠΌ ΡΠΎΡΠ½ΠΎΡΡΠΈ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΈΠΌ. Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ»ΠΎΠΆΠ½ΡΠΉ ΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠ½ΡΠΉ Π²Π°ΡΠΈΠ°Π½Ρ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π²ΠΎΠ΄ΠΈΡΠ΅Π»Ρ ΠΏΡΠΈ ΠΏΡΠΎΠ΅Π·Π΄Π΅ Π½Π΅ΡΠ΅Π³ΡΠ»ΠΈΡΡΠ΅ΠΌΠΎΠ³ΠΎ ΠΏΠ΅ΡΠ΅ΡΠ΅ΡΠ΅Π½ΠΈΡ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΠΏΡΠΈ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΡΠΎΠΊΠ° Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎ ΡΡΠΈΡΡΠ²Π°ΡΡ ΡΡΠ΅ΠΏΠ΅Π½Ρ ΡΠ΅ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Π²ΠΎΠ΄ΠΈΡΠ΅Π»Π΅ΠΉ (ΡΠ΅ΡΠ΅Π· ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΠ° ΡΠ΅ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈβ ΡΠ»ΡΡΠ°ΠΉΠ½ΡΡ Π²Π΅Π»ΠΈΡΠΈΠ½Ρ Ρ ΡΡΡΡΠΎΠΌ ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π²Π΅ΡΠΎΡΡΠ½ΠΎΡΡΠΈ Π΅Π³ΠΎ Π·Π½Π°ΡΠ΅Π½ΠΈΡ Π² ΡΠΎΠ²ΠΎΠΊΡΠΏΠ½ΠΎΡΡΠΈ Ρ ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ΠΌ Π²Π΅ΡΠΎΡΡΠ½ΠΎΡΡΠ΅ΠΉ ΡΡΠ½ΠΊΡΠΈΠΈ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΡΠΎΠΊΠ°). ΠΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½ΠΎ ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΠ° ΡΠ΅ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Π²ΠΎΠ΄ΠΈΡΠ΅Π»Π΅ΠΉ, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΠΎΠ΅ ΠΏΠΎ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠΌ Π΄Π°Π½Π½ΡΠΌ. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΎ, ΡΡΠΎ Π½Π° ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΠΎΠ³ΠΎ Π·Π°ΡΠΎΡΠ° ΠΎΠΊΠ°Π·ΡΠ²Π°Π΅Ρ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΡΡΠΈΠ»Ρ Π²ΠΎΠΆΠ΄Π΅Π½ΠΈΡ, Π΄Π»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΡΡ ΡΡΠ»ΠΎΠ²Π½ΡΡ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π²ΠΎΠ΄ΠΈΡΠ΅Π»Π΅ΠΉ Π½Π° Π΄ΠΎΡΠΎΠ³Π΅, Π°ΠΈΠΌΠ΅Π½Π½ΠΎ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΠ΅ Π°Π³ΡΠ΅ΡΡΠΈΠΈ ΠΈ ΡΠΎΠ±ΠΎΡΡΠΈ. ΠΡΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠΈ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΡΠΎΠ±ΠΊΠΈΡ
ΠΈ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΡΡ
Π²ΠΎΠ΄ΠΈΡΠ΅Π»Π΅ΠΉ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½ΠΎ Π½Π΅ΡΠΊΠΎΠ»ΡΠΊΠΎ ΠΏΠ°Ρ ΡΡΠ°Π΅ΠΊΡΠΎΡΠΈΠΉ Π΄Π²ΠΈΠΆΠ΅Π½ΠΈΡ ΠΈ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ° ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠ΅ΠΉ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΠΈ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΡΠΎΠΊΠ°, ΠΊΠΎΡΠΎΡΡΠ΅ ΡΠ°ΡΡΡΠΈΡΠ°Π½Ρ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΌΠΎΠ΄Π΅Π»ΠΈ Edieβs. ΠΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½ΠΎ, ΡΡΠΎ Π½Π°ΠΈΠ±ΠΎΠ»ΡΡΠ΅Π΅ ΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠ΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΡΠ΅ Π·Π°ΡΠΎΡΡ ΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡ Π½Π° Π²ΠΎΠ΄ΠΈΡΠ΅Π»Π΅ΠΉ-Ρ
ΠΎΠ»Π΅ΡΠΈΠΊΠΎΠ² ΠΈΠ½Π° Π²ΠΎΠ΄ΠΈΡΠ΅Π»Π΅ΠΉ-ΡΠ°Π½Π³Π²ΠΈΠ½ΠΈΠΊΠΎΠ². ΠΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, ΠΏΡΠΎΡΠ»Π΅ΠΆΠΈΠ²Π°Π΅ΡΡΡ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Ρ ΠΌΠ΅ΠΆΠ΄Ρ Π²ΡΠ΅ΠΌΠ΅Π½Π΅ΠΌ ΡΠ΅Π°ΠΊΡΠΈΠΈ Π²ΠΎΠ΄ΠΈΡΠ΅Π»Ρ ΠΈ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ Π΅Π³ΠΎ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ. Π‘Π΄Π΅Π»Π°Π½ Π²ΡΠ²ΠΎΠ΄, ΡΡΠΎ Π² ΡΠ΅Π»ΡΡ
ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ Π΄ΠΎΡΠΎΠΆΠ½ΠΎΠ³ΠΎ Π΄Π²ΠΈΠΆΠ΅Π½ΠΈΡ Π·Π° ΡΡΡΡ Π±ΠΎΠ»Π΅Π΅ ΡΠΎΡΠ½ΠΎΠΉ ΠΎΡΠ΅Π½ΠΊΠΈ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΡ
ΡΠΈΡΠΊΠΎΠ² Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ Π·Π°ΡΠΎΡΠΎΠ²ΡΡ
ΡΠΈΡΡΠ°ΡΠΈΠΉ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎ ΡΡΠΈΡΡΠ²Π°ΡΡ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΡΠ΅ΡΠΊΠΈΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ Π²ΠΎΠ΄ΠΈΡΠ΅Π»Π΅ΠΉ ΠΈ ΠΈΡ
ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΠΌΠ΅Π½ΡΡ
Correction of pathological conditions of the mucous membranes of the upper respiratory tract with seawater medicines
ENT specialists are increasingly concerned about high incidence of the mucous membrane disorders in the upper respiratory tract. To paraphrase a well-known expression, it can be argued that there are no patients with completely healthy noses and sips, but there are patients who have not yet got tired of constant tickling in the throat, mucus discharge, nasal congestion and other symptoms
Therapeutic and prevention potential of seawater medicines
The mucous membrane of the nasal cavity is the opening part of the respiratory tract which has a number of functions among which protection is the most important. Once in the nasal cavity, the inhaled air is mechanically cleaned of dust pollutants, humidified and warmed. About 10 thousand litres of air pass through the nose during a day. The nasal mucosa also hinders penetration of pathogens (bacteria, fungi, viruses) into the lungs
Pharyngomycosis. Diagnostics, prevention and treatment
The prevalence of pharyngomycosis was analysed on the basis of research data and own observation of 2,987 patients seeking assistance in the consulting unit of the Centre over the period from 2008 till 2011. The study concluded that the proportion of fungal infections of ENT organs in the total variety of chronic inflammatory disease increased to 29% for fungal infections of the throat in pharyngitis, and to 17.2% in chronic tonsillitis. The pathogens of fungal infections of the throat were defined and analyzed. The study found that the involvement of Candida non albicans strains in the development of chronic inflammation has increased. The proportion of cases of aspergillus infection of the mucous membranes of the pharynx, larynx, and tonsils was identified. Sophisticated diagnosis and treatment schemes were suggested
Treatment of inflammatory diseases of the throat
Inflammatory diseases of the upper respiratory tract are very widespread. There is a brief description and guidelines for the treatment of various forms of laryngitis. Inhalation antibiotic therapy is an effective method of local anti-inflammatory therapy in the comprehensive treatment of inflammatory diseases of the larynx
Reaction of quinaldine with 4,6-di(tert-butyl)-3-nitro-1,2-benzoquinone. Dependence of the outcome on the reaction conditions and a deeper insight into the mechanism
Condensation of quinaldine with 4,6-di (tert-butyl)-3-nitro-1,2-benzoquinone results in the formation of 5,7-di (tert-butyl)-2-(quinoline-2-yl)-1,3-tropolone, 5,7-di (tert-butyl)-4-nitro-2-(quinoline-2-yl)-1,3-tropolone, 3,3-dimethyl-2-(5-hydroxy-4-nitro-3-tert-butyl-6-quinoline-2-yl-pyridine-2-yl)butanoic acid, 6-(2,2-dimethylprop-3-yl)-5-tert-butyl-4-nitro-2-(quinoline-2-yl)-pyridine-3-ol, 1,7-di (tert-butyl)-3-(quinoline-2-yl)-2-azabicyclo-[3.3.0]octa-2,7-diene-4,6-dione-N-oxide. The formation of 1,3-tropolone and pyridine-2-yl butanoic acid derivatives proceeds through a ring expansion and 2-azabicyclo [3.3.0]octa-2,7-diene-4,6-dione-N-oxide via the contraction of the o-quinone ring. The structure of the heterocyclic compounds obtained was justified by X-ray diffraction analysis, NMR spectroscopy, IR- and HRMS-spectrometry, and the proposed mechanisms of their formation include the participation of an intermediate product of the expansion reaction of the o-quinone cycle - 5,7-di (tert-butyl)-4-nitro-2-(quinoline-2-yl)-cyclohepta-1,3,5-triene-1,3-diol, which was first isolated preparatively. The DFT/B3LYP/6β311++G** methods were used to determine the thermodynamic stability of tautomeric forms of intermediate products, as well as the relative stability of NH and OH tautomers of 5,7-di (tert-butyl)-2-(quinolin-2-yl)-1,3-tropolone and 5,7-di (tert-butyl)-4-nitro-2-(quinolin-2-yl)-1,3-tropolone