Association of lower urinary tract symptoms and testosterone deficiency in men with type 2 diabetes

INTRODUCTION AND OBJECTIVES: Type 2 diabetes mellitus, as a chronic systemic metabolic disease, is widely spread in the population of middle- aged men. Previously it has been proven the link between the presence of type 2 diabetes and the development of lower urinary tract symptoms in men. At the same time, middle-aged men are characterized by the appearance and progression of benign prostatic hyperplasia.MATERIAL AND METHODS: We performed a study of middle-aged men with type 2 diabetes to determine the interrelation of micturition disorders with deficiency of serum testosterone, in respect that the pathophysiology of prostatic hyperplasia is regarded as dysmetabolic dyshormonal state. The prospective study examined 112 men with type 2 diabetes randomized by the level of total testosterone. Lower urinary tract symptoms were assessed by I-PSS questionnaire. The study of serum total PSA, uroflowmetry, transrectal prostate ultrasonography were performed.RESULTS: As a result of the study the association between the severity of type 2 diabetes mellitus and the decrease in total testosterone levels was determined. The relationship of testosterone deficiency and the frequency of the presence and severity of lower urinary tract symptoms were demonstrated. The dependence of the prostate hyperplasia risks progression with the level of serum testosterone was found.CONCLUSIONS: The association of testosterone deficiency with frequency and severity of lower urinary tract symptoms, partially related with benign prostatic hyperplasia and clinically defined detrusor cistopathy, has been proven. Further clinical studies are needed to determine the pathophysiological and pathomorphological features of type 2 diabetes, which determines the development of detrusor cistopathy and late onset hypigonadism

Palaeomagnetism of East Siberian traps and kimberlites: two new poles and palaeogeographic reconstructions at about 360 and 250Ma

International audienceWe studied basalt sills and dykes and kimberlite pipes from the eastern part of the Siberian platform. These are spread out over a few hundred kilometres and are divided into two age groups: Late Permian-Early Triassic (Mir, Aikhal and Olenyek regions) and Late Devonian-Early Carboniferous (Viluy and Markha basins, Aikhal region). The palaeomagnetic poles determined for each sill or dyke are statistically different from each other, but averaging all corresponding directions from these sills and dykes with those from kimberlites of different generations yields results with acceptable statistics. This is probably due to the averaging out of secular variation and/or changes in magnetic polarity. The resulting palaeomagnetic poles allow one to reconstruct the palaeopositions of Siberia during the two large flood basalt events at about 360 and 250Ma. A significant rotation of the Siberian platform during the Devonian and Carboniferous is suggested. The new data are in general agreement with some earlier palaeomagnetic poles for the Late Permian-Early Triassic traps of the Tungusska basin, and significantly reduce uncertainties for previous Late Devonian-Early Carboniferous Siberian poles, which were very scattered. Together with geological and absolute age data, the palaeomagnetic data support the hypothesis that kimberlite magmatism and trap intrusions were both rapid and relatively close in time. The 360Ma event is emerging as a magmatic event with considerable extent over the Russian and Siberian platforms, related to incipient continental break-up and triple junction formation, possibly at or near the time of the Frasnian-Famennian mass extinction

The features of erectile dysfunction in type 2 diabetes and serum testosterone deficiency

The current literature is lacking sufficient coverage of the relationship between erectile dysfunction (ED) and diabetes mellitus (DM), and age-related hypogonadism. At the same time, the mutual impact of cardiovascular and endocrine systems on men erectile function and the resulting damage of male sexual organs are being studied and debated. This prospective, randomized, simple comparative study examined the erectile function of 131 men with type 2 DM and age-related hypogonadism, tested the effects of DM on serum testosterone, formed an idea of possible relationship between DM, severity of ED and testosterone levels, degree of endothelial dysfunction and the involvement of the testicles. The study results showed the impact of testosterone level on the compensation of DM and frequency of ED. Correlations were observed between testosterone levels, peak systolic velocity of blood flow in the of capsular arteries of testes and testicular size. The interrelation between testicular size, reduction of testicular blood flow, and DM-related endothelial dysfunction and variability of serum testosterone levels was found. The findings suggest the need for revising existing reference ranges for serum testosterone upward to 15 nmol/L