287 research outputs found

    Materials for the study of postcolonial Africa in the LDS Church History Library: manuscripts

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    African Studies Center Working Paper No. 272INTRODUCTION This bibliography contains manuscript materials relevant to the study of postcolonial Africa located in the Church History Library of the Church of Jesus Christ of Latter-day Saints (LDS Church) in downtown Salt Lake City, Utah. I have organized this list alphabetically by country. Whenever manuscript collections are relevant to the history of multiple countries, I have crosslisted the collections for the sake of convenience. I have chosen to exclude closed and unprocessed collections from this bibliography, so this list will be outdated by the time it is published. Nevertheless, I hope that the compilation of this bibliography of manuscript materials in the LDS Church History Library will assist historians in writing the history of Africa after 1960

    Liver-specific knockout of arginase-1 leads to a profound phenotype similar to inducible whole body arginase-1 deficiency

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    Arginase-1 (Arg1) converts arginine to urea and ornithine in the distal step of the urea cycle in liver. We previously generated a tamoxifen-inducible Arg1 deficient mouse model (Arg1-Cre) that disrupts Arg1 expression throughout the whole body and leads to lethality ≈ 2 weeks after gene disruption. Here, we evaluate if liver-selective Arg1 loss is sufficient to recapitulate the phenotype observed in global Arg1 knockout mice, as well as to gauge the effectiveness of gene delivery or hepatocyte transplantation to rescue the phenotype. Liver-selective Arg1 deletion was induced by using an adeno-associated viral (AAV)-thyroxine binding globulin (TBG) promoter-Cre recombinase vector administered to Arg1 "floxed" mice; Arg1(fl/fl) ). An AAV vector expressing an Arg1-enhanced green fluorescent protein (Arg1-eGFP) transgene was used for gene delivery, while intrasplenic injection of wild-type (WT) C57BL/6 hepatocytes after partial hepatectomy was used for cell delivery to "rescue" tamoxifen-treated Arg1-Cre mice. The results indicate that liver-selective loss of Arg1 (> 90% deficient) leads to a phenotype resembling the whole body knockout of Arg1 with lethality ≈ 3 weeks after Cre-induced gene disruption. Delivery of Arg1-eGFP AAV rescues more than half of Arg1 global knockout male mice (survival > 4 months) but a significant proportion still succumb to the enzyme deficiency even though liver expression and enzyme activity of the fusion protein reach levels observed in WT animals. Significant Arg1 enzyme activity from engrafted WT hepatocytes into knockout livers can be achieved but not sufficient for rescuing the lethal phenotype. This raises a conundrum relating to liver-specific expression of Arg1. On the one hand, loss of expression in this organ appears to be both necessary and sufficient to explain the lethal phenotype of the genetic disorder in mice. On the other hand, gene and cell-directed therapies suggest that rescue of extra-hepatic Arg1 expression may also be necessary for disease correction. Further studies are needed in order to illuminate the detailed mechanisms for pathogenesis of Arg1-deficiency

    LDS materials for the study of Sub-Saharan Africa at L. Tom Perry Special Collections, Brigham Young University

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    This brief working paper contains a list of archival materials for the study of both colonial and postcolonial Sub-Saharan Africa located at L. Tom Perry Special Collections, Harold B. Lee Library, Brigham Young University, Provo, Utah. It supplements previous bibliographies I have published on Latter-day Saint materials for the study of Sub-Saharan Africa in this same working paper series. The current bibliography, which I have organized alphabetically by country, includes African oral histories; the papers, diaries, and oral histories of LDS missionaries, American diplomats, and U.S. Peace Corps volunteers; and records relating to the Boy Scouts in Africa. Collections relevant to the history of multiple countries have been cross-listed for the sake of convenience

    Materials for the study of postcolonial Africa in the LDS church history library: manuscripts

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    This bibliography contains manuscript materials relevant to the study of postcolonial Africa located in the Church History Library of the Church of Jesus Christ of Latter-day Saints (LDS Church) in downtown Salt Lake City, Utah. I have organized this list alphabetically by country. Whenever manuscript collections are relevant to the history of multiple countries, I have crosslisted the collections for the sake of convenience. I have chosen to exclude closed and unprocessed collections from this bibliography, so this list will be outdated by the time it is published. Nevertheless, I hope that the compilation of this bibliography of manuscript materials in the LDS Church History Library will assist historians in writing the history of Africa after 1960

    Transmission Planning Process and Opportunities for Utility-Scale Solar Engagement within the Western Electricity Coordinating Council (WECC)

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    This report is a primer for solar developers who wish to engage directly in expediting the regulatory process and removing market barriers related to policy and planning. Market barriers unrelated to technology often limit the expansion of utility-scale solar power, even in areas with exceptional resource potential. Many of these non-technical barriers have to do with policy, regulation, and planning, and hardly ever do they resolve themselves in a timely fashion. In most cases, pre-emptive intervention by interested stakeholders is the easiest way to remove/address such barriers, but it requires knowing how to navigate the institutional waters of the relevant agencies and boards. This report is a primer for solar developers who wish to engage directly in expediting the regulatory process and removing market barriers related to policy and planning. It focuses on the Western Interconnection (WI), primarily because the quality of solar resources in the Southwest makes utility-scale concentrating solar power (CSP) and photovoltaics (PV) economically feasible, and because the relevant institutions have evolved in a way that has opened up opportunities for removing non-technical market barriers. Developers will find in this report a high-level field manual to identify the venues for mitigating and possibly eliminating systemic market obstacles and ensuring that the economic playing field is reasonably level. Project-specific issues such as siting for transmission and generation resources are beyond the scope of this report. Instead, the aim is to examine issues that pervasively affect all utility-scale PV and CSP in the region regardless of where the project may be. While the focus is on the WI, many of the institutions described here also have their counterparts in the Eastern and the Texas interconnections. Specifically, this report suggests a number of critical engagement points relating to generation and transmission planning

    Book Review Panel: When Souls Had Wings: Pre-mortal Existence in Western Thought

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    On October 13, 2011, BYU Studies sponsored a program reviewing Terryl Givens’s important Oxford book on the idea of the premortal existence of souls in various lines of Western philosophy and religion. Because this first volume of its kind covers literature from so many different civilizations, the editors of BYU Studies saw no way to do this book justice without involving a panel of reviewers from several disciplines. After portions of Robert Fuller’s forthcoming review in Church History were read, the program proceeded with reviews, responses, and open discussion

    Navajo Generating Station and Clean-Energy Alternatives: Options for Renewables

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    In January 2012, the National Renewable Energy Laboratory delivered to the Department of the Interior the first part of a study on Navajo Generating Station (Navajo GS) and the likely impacts of BART compliance options. That document establishes a comprehensive baseline for the analysis of clean energy alternatives, and their ability to achieve benefits similar to those that Navajo GS currently provides. This analysis is a supplement to NREL's January 2012 study. It provides a high level examination of several clean energy alternatives, based on the previous analysis. Each has particular characteristics affecting its relevance as an alternative to Navajo GS. It is assumed that the development of any alternative resource (or portfolio of resources) to replace all or a portion of Navajo GS would occur at the end of a staged transition plan designed to reduce economic disruption. We assume that replacing the federal government's 24.3% share of Navajo GS would be a cooperative responsibility of both the U.S. Bureau of Reclamation (USBR) and the Central Arizona Water Conservation District (CAWCD)
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