278 research outputs found
Pair Creation and an X-ray Free Electron Laser
Using a quantum kinetic equation coupled to Maxwell's equation we study the
possibility that focused beams at proposed X-ray free electron laser facilities
can generate electric field strengths large enough to cause spontaneous
electron-positron pair production from the QED vacuum. Our approach yields the
time and momentum dependence of the single particle distribution function.
Under conditions reckoned achievable at planned facilities, repeated cycles of
particle creation and annihilation take place in tune with the laser frequency.
However, the peak particle number density is insensitive to this frequency and
one can anticipate the production of a few hundred particle pairs per laser
period. Field-current feedback and quantum statistical effects are small and
can be neglected in this application of non-equilibrium quantum mean field
theory.Comment: 4 pages, LaTeX2
NCBI GEO: archive for high-throughput functional genomic data
The Gene Expression Omnibus (GEO) at the National Center for Biotechnology Information (NCBI) is the largest public repository for high-throughput gene expression data. Additionally, GEO hosts other categories of high-throughput functional genomic data, including those that examine genome copy number variations, chromatin structure, methylation status and transcription factor binding. These data are generated by the research community using high-throughput technologies like microarrays and, more recently, next-generation sequencing. The database has a flexible infrastructure that can capture fully annotated raw and processed data, enabling compliance with major community-derived scientific reporting standards such as âMinimum Information About a Microarray Experimentâ (MIAME). In addition to serving as a centralized data storage hub, GEO offers many tools and features that allow users to effectively explore, analyze and download expression data from both gene-centric and experiment-centric perspectives. This article summarizes the GEO repository structure, content and operating procedures, as well as recently introduced data mining features. GEO is freely accessible at http://www.ncbi.nlm.nih.gov/geo/
Methanol Masers as Tracers of Circumstellar Disks
We show that in many methanol maser sources the masers are located in lines,
with a velocity gradient along them which suggests that the masers are situated
in edge-on circumstellar, or protoplanetary, disks. We present VLBI
observations of the methanol maser source G309.92+0.48, in the 12.2 GHz
transition, which confirm previous observations that the masers in this source
lie along a line. We show that such sources are not only linear in space but,
in many cases, also have a linear velocity gradient. We then model these and
other data in both the 6.7 GHz and the 12.2 GHz transition from a number of
star formation regions, and show that the observed spatial and velocity
distribution of methanol masers, and the derived Keplerian masses, are
consistent with a circumstellar disk rotating around an OB star. We consider
this and other hypotheses, and conclude that about half of these methanol
masers are probably located in edge-on circumstellar disks around young stars.
This is of particular significance for studies of circumstellar disks because
of the detailed velocity information available from the masers.Comment: 38 pages, 13 figures accepted by Ap
The grant is dead, long live the data - migration as a pragmatic exit strategy for research data preservation [version 2; peer review: 2 approved]
Does Manual Therapy Provide Additional Benefit To Breathing Retraining In The Management Of Dysfunctional Breathing? A Randomised Controlled Trial
Purpose: Dysfunctional breathing (DB) is associated with an abnormal breathing pattern, unexplained breathlessness and significant patient morbidity. Treatment involves breathing retraining through respiratory physiotherapy. Recently, manual therapy (MT) has also been used, but no evidence exists to validate its use. This study sought to investigate whether MT produces additional benefit when compared with breathing retraining alone in patients with DB. Methods: Sixty subjects with primary DB were randomised into either breathing retraining (standard treatment; nŒ30) or breathing retraining plus MT (intervention; nŒ30) group. Both the groups received standardised respiratory physiotherapy, which included: DB education, breathing retraining, home regimen, and audio disc. Intervention group subjects additionally received MT following further assessment. Data from 57 subjects were analysed. Results: At baseline, standard treatment group subjects were statistically younger (41.7 + 13.5 versus 50.8 + 13.0 years; pŒ0.001) with higher Nijmegen scores (38.6 + 9.5 versus 31.5 + 6.9; pŒ0.001). However, no significant difference was found between the groups for primary outcome Nijmegen score (95% CI ( 1.1, 6.6) pŒ0.162), or any secondary outcomes (Hospital Anxiety & Depression Score, spirometry or exercise tolerance). Conclusion: Breathing retraining is currently the mainstay of treatment for patients with DB. The results of this study suggest MT provides
no additional benefit in this patient group.Juliana Burgess, Dr Robert Wilson, Royal Brompton & Harefield NHS Foundation Trust, and Dr Andy Jones fo
Maternal iron deficiency perturbs embryonic cardiovascular development in mice.
Congenital heart disease (CHD) is the most common class of human birth defects, with a prevalence of 0.9% of births. However, two-thirds of cases have an unknown cause, and many of these are thought to be caused by in utero exposure to environmental teratogens. Here we identify a potential teratogen causing CHD in mice: maternal iron deficiency (ID). We show that maternal ID in mice causes severe cardiovascular defects in the offspring. These defects likely arise from increased retinoic acid signalling in ID embryos. The defects can be prevented by iron administration in early pregnancy. It has also been proposed that teratogen exposure may potentiate the effects of genetic predisposition to CHD through gene-environment interaction. Here we show that maternal ID increases the severity of heart and craniofacial defects in a mouse model of Down syndrome. It will be important to understand if the effects of maternal ID seen here in mice may have clinical implications for women
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