1,736 research outputs found
Generic Subsequence Matching Framework: Modularity, Flexibility, Efficiency
Subsequence matching has appeared to be an ideal approach for solving many
problems related to the fields of data mining and similarity retrieval. It has
been shown that almost any data class (audio, image, biometrics, signals) is or
can be represented by some kind of time series or string of symbols, which can
be seen as an input for various subsequence matching approaches. The variety of
data types, specific tasks and their partial or full solutions is so wide that
the choice, implementation and parametrization of a suitable solution for a
given task might be complicated and time-consuming; a possibly fruitful
combination of fragments from different research areas may not be obvious nor
easy to realize. The leading authors of this field also mention the
implementation bias that makes difficult a proper comparison of competing
approaches. Therefore we present a new generic Subsequence Matching Framework
(SMF) that tries to overcome the aforementioned problems by a uniform frame
that simplifies and speeds up the design, development and evaluation of
subsequence matching related systems. We identify several relatively separate
subtasks solved differently over the literature and SMF enables to combine them
in straightforward manner achieving new quality and efficiency. This framework
can be used in many application domains and its components can be reused
effectively. Its strictly modular architecture and openness enables also
involvement of efficient solutions from different fields, for instance
efficient metric-based indexes. This is an extended version of a paper
published on DEXA 2012.Comment: This is an extended version of a paper published on DEXA 201
Thermoelastic Damping in Micro- and Nano-Mechanical Systems
The importance of thermoelastic damping as a fundamental dissipation
mechanism for small-scale mechanical resonators is evaluated in light of recent
efforts to design high-Q micrometer- and nanometer-scale electro-mechanical
systems (MEMS and NEMS). The equations of linear thermoelasticity are used to
give a simple derivation for thermoelastic damping of small flexural vibrations
in thin beams. It is shown that Zener's well-known approximation by a
Lorentzian with a single thermal relaxation time slightly deviates from the
exact expression.Comment: 10 pages. Submitted to Phys. Rev.
Fatal encephalitis and myocarditis in young domestic geese (Anser anser domesticus) caused by West Nile virus.
During 1999 and 2000, a disease outbreak of West Nile (WN) virus occurred in humans, horses, and wild and zoological birds in the northeastern USA. In our experiments, WN virus infection of young domestic geese (Anser anser domesticus) caused depression, weight loss, torticollis, opisthotonus, and death with accompanying encephalitis and myocarditis. Based on this experimental study and a field outbreak in Israel, WN virus is a disease threat to young goslings and viremia levels are potentially sufficient to infect mosquitoes and transmit WN virus to other animal species
Cold Nuclear Matter In Holographic QCD
We study the Sakai-Sugimoto model of holographic QCD at zero temperature and
finite chemical potential. We find that as the baryon chemical potential is
increased above a critical value, there is a phase transition to a nuclear
matter phase characterized by a condensate of instantons on the probe D-branes
in the string theory dual. As a result of electrostatic interactions between
the instantons, this condensate expands towards the UV when the chemical
potential is increased, giving a holographic version of the expansion of the
Fermi surface. We argue based on properties of instantons that the nuclear
matter phase is necessarily inhomogeneous to arbitrarily high density. This
suggests an explanation of the "chiral density wave" instability of the quark
Fermi surface in large N_c QCD at asymptotically large chemical potential. We
study properties of the nuclear matter phase as a function of chemical
potential beyond the transition and argue in particular that the model can be
used to make a semi-quantitative prediction of the binding energy per nucleon
for nuclear matter in ordinary QCD.Comment: 31 pages, LaTeX, 1 figure, v2: some formulae corrected, qualitative
results unchange
The effects of an intronic polymorphism in TOMM40 and APOE genotypes in sporadic inclusion body myositis.
A previous study showed that, in carriers of the apolipoprotein E (APOE) genotype Īµ3/Īµ3 or Īµ3/Īµ4, the presence of a very long (VL) polyT repeat allele in "translocase of outer mitochondrial membrane 40" (TOMM40) was less frequent in patients with sporadic inclusion body myositis (sIBM) compared with controls and associated with a later age of sIBM symptom onset, suggesting a protective effect of this haplotype. To further investigate the influence of these genetic factors in sIBM, we analyzed a large sIBM cohort of 158 cases as part of an International sIBM Genetics Study. No significant association was found between APOE or TOMM40 genotypes and the risk of developing sIBM. We found that the presence of at least 1 VL polyT repeat allele in TOMM40 was significantly associated with about 4 years later onset of sIBM symptoms. The age of onset was delayed by 5 years when the patients were also carriers of the APOE genotype Īµ3/Īµ3. In addition, males were likely to have a later age of onset than females. Therefore, the TOMM40 VL polyT repeat, although not influencing disease susceptibility, has a disease-modifying effect on sIBM, which can be enhanced by the APOE genotype Īµ3/Īµ3
Cathelicidin suppresses lipid accumulation and hepatic steatosis by inhibition of the CD36 receptor.
Background and objectivesObesity is a global epidemic which increases the risk of the metabolic syndrome. Cathelicidin (LL-37 and mCRAMP) is an antimicrobial peptide with an unknown role in obesity. We hypothesize that cathelicidin expression correlates with obesity and modulates fat mass and hepatic steatosis.Materials and methodsMale C57BL/6āJ mice were fed a high-fat diet. Streptozotocin was injected into mice to induce diabetes. Experimental groups were injected with cathelicidin and CD36 overexpressing lentiviruses. Human mesenteric fat adipocytes, mouse 3T3-L1 differentiated adipocytes and human HepG2 hepatocytes were used in the in vitro experiments. Cathelicidin levels in non-diabetic, prediabetic and type II diabetic patients were measured by enzyme-linked immunosorbent assay.ResultsLentiviral cathelicidin overexpression reduced hepatic steatosis and decreased the fat mass of high-fat diet-treated diabetic mice. Cathelicidin overexpression reduced mesenteric fat and hepatic fatty acid translocase (CD36) expression that was reversed by lentiviral CD36 overexpression. Exposure of adipocytes and hepatocytes to cathelicidin significantly inhibited CD36 expression and reduced lipid accumulation. Serum cathelicidin protein levels were significantly increased in non-diabetic and prediabetic patients with obesity, compared with non-diabetic patients with normal body mass index (BMI) values. Prediabetic patients had lower serum cathelicidin protein levels than non-diabetic subjects.ConclusionsCathelicidin inhibits the CD36 fat receptor and lipid accumulation in adipocytes and hepatocytes, leading to a reduction of fat mass and hepatic steatosis in vivo. Circulating cathelicidin levels are associated with increased BMI. Our results demonstrate that cathelicidin modulates the development of obesity
Quantum geometry and gravitational entropy
Most quantum states have wavefunctions that are widely spread over the
accessible Hilbert space and hence do not have a good description in terms of a
single classical geometry. In order to understand when geometric descriptions
are possible, we exploit the AdS/CFT correspondence in the half-BPS sector of
asymptotically AdS_5 x S^5 universes. In this sector we devise a
"coarse-grained metric operator" whose eigenstates are well described by a
single spacetime topology and geometry. We show that such half-BPS universes
have a non-vanishing entropy if and only if the metric is singular, and that
the entropy arises from coarse-graining the geometry. Finally, we use our
entropy formula to find the most entropic spacetimes with fixed asymptotic
moments beyond the global charges.Comment: 29 pages, 2 figures; references adde
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Environmental management policy analysis using complex system simulation
The two primary modules of Envirosim (the model of Los Alamos TA-55 and the WIPP transport/storage model) have been combined into one application, with the simulated waste generated by TA-55 operations being fed to storage, packaging, and transport simulation entities. Three simulation scenarios were executed which demonstrate the usefulness of Envirosim as a policy analysis tool for use in planning shipments to WIPP. A graphical user interface (GUI) has been implemented using IDL (Interactive Data Language) which allows the analyst to easily view simulation results. While IDL is not necessarily the graphics interface that would be selected for a production version of Envirosim, it does provide some powerful data manipulation capabilities, and it runs on a variety of platforms
Landau Levels, Magnetic Fields and Holographic Fermi Liquids
We further consider a probe fermion in a dyonic black hole background in
anti-de Sitter spacetime, at zero temperature, comparing and contrasting two
distinct classes of solution that have previously appeared in the literature.
Each class has members labeled by an integer n, corresponding to the n-th
Landau level for the fermion. Our interest is the study of the spectral
function of the fermion, interpreting poles in it as indicative of
quasiparticles associated with the edge of a Fermi surface in the
holographically dual strongly coupled theory in a background magnetic field H
at finite chemical potential. Using both analytical and numerical methods, we
explicitly show how one class of solutions naturally leads to an infinite
family of quasiparticle peaks, signaling the presence of a Fermi surface for
each level n. We present some of the properties of these peaks, which fall into
a well behaved pattern at large n, extracting the scaling of Fermi energy with
n and H, as well as the dispersion of the quasiparticles.Comment: 23 pages, 4 figures. Changed some of the terminology: non-separable
-> infinite-sum. Clarified the relationship between our ansatz and the
separable ansat
Strings on Bubbling Geometries
We study gauge theory operators which take the form of a product of a trace
with a Schur polynomial, and their string theory duals. These states represent
strings excited on bubbling AdS geometries which are dual to the Schur
polynomials. These geometries generically take the form of multiple annuli in
the phase space plane. We study the coherent state wavefunction of the lattice,
which labels the trace part of the operator, for a general Young tableau and
their dual description on the droplet plane with a general concentric ring
pattern. In addition we identify a density matrix over the coherent states on
all the geometries within a fixed constraint. This density matrix may be used
to calculate the entropy of a given ensemble of operators. We finally recover
the BMN string spectrum along the geodesic near any circle from the ansatz of
the coherent state wavefunction.Comment: 41 pages, 12 figures, published version in JHE
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