Targeting chromatin aging - the epigenetic impact of longevity-associated interventions

A rapidly growing body of evidence has shown that chromatin undergoes radical alterations as an organism ages, but how these changes relate to aging itself is an open question. It is likely that these processes contribute to genomic instability and loss of transcriptional fidelity, which in turn drives deleterious age-related phenotypes. Interventions associated with increased healthspan and longevity such as reduced insulin/IGF signalling (IIS), inhibition of mTOR and energy depletion resulting in SIRT1/AMPK activation, all have beneficial effects which ameliorate multiple facets of age-associated decline. The impact of these interventions on the epigenome is less certain. In this review we highlight the potential of these interventions to act directly upon the epigenome and promote a youthful chromatin landscape, maintaining genetic and transcriptional memory throughout the lifecourse. We propose that this is a fundamental mechanism through which these interventions are able to curtail the incidence of age-related disease. By revisiting these well characterised interventions, we may be able to identify targetable effectors of chromatin function and use this knowledge to enhance healthspan and longevity in human populations through the measured application of dietary and small molecule interventions

The energy dependence of p_t angular correlations inferred from mean-p_t fluctuation scale dependence in heavy ion collisions at the SPS and RHIC

We present the first study of the energy dependence of pt angular correlations inferred from event-wisemean transverse momentum (pt) fluctuations in heavy ion collisions. We compare our large-acceptancemeasurements at CM energies √^sNN = 19.6, 62.4, 130 and 200 GeV to SPS measurements at 12.3 and 17.3 GeV. p_t angular correlation structure suggests that the principal source of p_t correlations and fluctuations is minijets (minimum-bias parton fragments). We observe a dramatic increase in correlations and fluctuations from SPS to RHIC energies, increasing linearly with ln √^sNN from the onset of observable jet-related (p_t) fluctuations near 10 GeV

Stiffness reductions during tensile fatigue testing of graphite/epoxy angle-ply laminates

Tensile fatigue data was generated under carefully controlled test conditions. A computerized data acquisition system was used to permit the measurement of dynamic modulus without interrupting the fatigue cycling. Two different 8-ply laminate configurations, viz, + or - 45 (2s) and + or - 67.5 (2s), of a T300/5208 graphite/epoxy composite were tested. The + or - 45 (2s) laminate did exhibit some modulus decay, although there was no well-defined correlation with applied stress level or number of cycles. The + or - 67.5 (2s) laminate did not exhibit any measurable modulus decay. Secondary effects observed included a small but distinct difference between modulus as measured statically and dynamically, a slight recovery of the modulus decay after a test interruption, and a significant viscoelastic (creep) response of the + or - 45 (2s) laminate during fatigue testing

Remote Stratigraphic Analysis: Combined TM and AIS Results in the Wind River/bighorn Basin Area, Wyoming

An in-progress study demonstrates the utility of airborne imaging spectrometer (AIS) data for unraveling the stratigraphic evolution of a North American, western interior foreland basin. AIS data are used to determine the stratigraphic distribution of mineralogical facies that are diagnostic of specific depositional environments. After wavelength and amplitude calibration using natural ground targets with known spectral characteristics, AIS data identify calcite, dolomite, gypsum and montmorillonite-bearing strata in the Permian-Cretaceous sequence. Combined AIS and TM results illustrate the feasibility of spectral stratigraphy, remote analysis of stratigraphic sequences

Integrated maneuvering and life support system simulation Final report

Integrated maneuvering and life support system simulatio

Evaluation of a stall-flutter spring-damper pushrod in the rotating control system of a CH-54B helicopter

Results of a design and flight test program conducted to define the effect of rotating pushrod damping on stall-flutter induced control loads are presented. The CH-54B helicopter was chosen as the test aircraft because it exhibited stall induced control loads. Damping was introduced into the CH-54B control system by replacing the standard pushrod with spring-damper assemblies. Design features of the spring-damper are described and the results of a dynamic analysis are shown which define the pushrod stiffness and damping requirements. Flight test measurements taken at 47,000 lb gross weight with and without the damper are presented. The results indicate that the spring-damper pushrods reduced high frequency, stall-induced rotating control loads by almost 50%. Fixed system control loads were reduced by 40%. Handling qualities in stall were unchanged, as expected

Standing on Academic Shoulders: Measuring Scientific Influence in Universities

This article measures scientific influence by means of citations to academic papers. The data source is the Institute for Scientific Information (ISI); the scientific institutions included are the top 110 U.S. research universities; the 12 main fields that classify the data cover nearly all of science; and the time period is 1981-1999. Altogether the database includes 2.4 million papers and 18.8 million citations. Thus the evidence underlying our findings accounts for much of the basic research conducted in the United States during the last quarter of the 20th century. This research in turn contributes a significant part of knowledge production in the U.S. during the same period. The citation measure used is the citation probability, which equals actual citations divided by potential citations, and captures average utilization of cited literature by individual citing articles. The mean citation probability within fields is on the order of 10-5. Cross-field citation probabilities are one-tenth to one-hundredth as large, or 10-6 to 10-7. Citations between pairs of citing and cited fields are significant in less than one-fourth of the possible cases. It follows that citations are largely bounded by field, with corresponding implications for the limits of scientific influence. Cross-field citation probabilities appear to be symmetric for mutually citing fields. Scientific influence is asymmetric within fields, and occurs primarily from top institutions to those less highly ranked. Still, there is significant reverse influence on higher-ranked schools. We also find that top institutions are more often cited by peer institutions than lower-ranked institutions are cited by their peers. Overall the results suggest that knowledge spillovers in basic science research are important, but are circumscribed by field and by intrinsic relevance. Perhaps the most important implication of the results are the limits that they seem to impose on the returns to scale in the knowledge production function for basic research, namely the proportion of available knowledge that spills over from one scientist to another.