Body mass index does not impact on molecular response rate of chronic myeloid leukaemia patients treated frontline with second generation tyrosine kinase inhibitors.

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Long-term follow-up of Philadelphia chromosome-positive (Ph+) chronic myeloid leukaemia (CML) in children and adolescents managed at a single institution over a 20-year period

Chronic myeloid leukaemia (CML) is rare in childhood. In our Institution we managed 30 consecutive Ph+CML patients aged <18 years, according to our adults’ guidelines. Patients with HLA-identical related donor (RD) underwent stem cell transplant (SCT). Since 1989, patients without RD were systematically treated with -interferon (IFN) (median dosage: 6 MU/day). Of 18/19 evaluable patients, 17 (94.5%) achieved haematologic response (HR), 11/17 (65%) cytogenetic response (CyR), complete (CCyR) in 4 (23.5%). Three patients remain in CCyR, 2 achieved BCR-ABL transcript disappearance. Of 13 patients without CCyR, 5 underwent SCT, 4 switched to STI571, 4 progressed. All patients receiving STI571 in chronic phase (CP) obtained sustained CCyR and 3 a persistent molecular response. 8-year survival among IFN-treated patients, censored or not for subsequent therapies, is 62% and 63%. Overall, 13/30 patients underwent SCT: 5 HLA-identical-RD, 5 matched unrelated donor, 2 mismatched-RD, 1 unrelated mismatched umbilical cord blood. Eight allotransplanted patients (6/6 in 1st CP) are in cytogenetic and molecular remission with 8-year survival of 61% from SCT and 69% from diagnosis. In our 20-year experience, the use of IFN in children without matched RD led to prolonged cytogenetic and molecular responses and long-term survival, without impairing the outcome of subsequent SCT

Dalla Corte costituzionale due recenti e inequivoche indicazioni circa la necessità di interpretare i principi della nostra Costituzione economica in conformità all’ordinamento dell’Unione europea

Il presente contributo si propone di analizzare l’ordinanza n. 35 e la sentenza n. 36 della Corte costituzionale italiana, depositate lo scorso 7 marzo, alla luce degli spunti di riflessione di ordine generale che queste offrono in merito alla rilevanza costituzionale dei principi del diritto del mercato interno dell’UE, con particolare riferimento alle sue libertà fondamentali e alla necessità per i legislatori nazionali di conformarvisi in sede di disciplina delle attività economiche.The aim of this paper is to analyse Order No. 35 and Judgment No. 36 of the Italian Constitutional Court, filed this past 7 March, in light of the general insights they offer regarding the constitutional relevance of the EU’s internal market law principles, specifically in relation to its fundamental freedoms and the need of national legislators to comply therewith when regulating economic activities

Prognostic impact of genetic characterization in the GIMEMA LAM99P multicenter study for newly diagnosed acute myeloid leukemia

Recent advances in genetic characterization of acute myeloid leukemia indicate that combined cytogenetic and molecular analyses provide better definition of prognostic groups. The aim of this study was to verify this prospectively in a large group of patients

Discontinuation of alpha-interferon treatment in patients with chronic myeloid leukemia in long-lasting complete molecular response

To evaluate follow-up after α-interferon (IFN) discontinuation, 23 patients with chronic myeloid leukemia (CML) in stable complete molecular response (CMolR) with IFN were revisited. After a median IFN treatment of 105.8 months (IR 56.1 - 127.3), all patients discontinued IFN for prolonged CMolR (12), intolerance (8) or planned ABMT (3). After 12.5 months, one patient developed an extramedullar blast crisis. Four patients needed to start imatinib, all achieving again molecular response. Eighteen patients are still off-therapy (median time from IFN discontinuation 125.5 months, IR 86.9-205.3); among these, five are BCR-ABL negative, six present with a sporadic positivity (BCR-ABL ratio &lt; 0.1) and seven show a stable and long-lasting mild positivity (BCR-ABL ratio &lt; 0.5). Patients in prolonged CMolR with IFN have low risk of recurrence after discontinuation; the reappearance of a BCR-ABL positivity &lt; 0.5 did not always precede a relapse, suggesting mechanisms of immunological control induced by IFN

Rationality in Differential Algebraic Geometry

Parametric Cartan theory of exterior differential systems, and explicit cohomology of projective manifolds reveal united rationality features of differential algebraic geometry.Comment: Abel Symposium 201