Simplicial complexes and complex systems

© 2018 European Physical Society. We provide a short introduction to the field of topological data analysis (TDA) and discuss its possible relevance for the study of complex systems. TDA provides a set of tools to characterise the shape of data, in terms of the presence of holes or cavities between the points. The methods, based on the notion of simplicial complexes, generalise standard network tools by naturally allowing for many-body interactions and providing results robust under continuous deformations of the data. We present strengths and weaknesses of current methods, as well as a range of empirical studies relevant to the field of complex systems, before identifying future methodological challenges to help understand the emergence of collective phenomena

Experimental behavior of existing RC columns strengthened with HPFRC jacket under concentric and eccentric compressive load

Reinforced concrete (RC) structures built before the 1970 represent a large portion of the existing European buildings stock. Their obsolescence in terms of design criteria, materials, and functionality is becoming a critical issue for guaranteeing adequate compliance with current structural codes. Recently, a new jacketing system based on the use of high-performance fiber-reinforced concrete (HPFRC) has been introduced for strengthening existing RC building members. Despite the promising aspects of the HPFRC jacketing technique, currently, a comprehensive and systematic technical framework for its implementation is still missing. In this paper, the experimental performance of RC columns strengthened with the HPFRC jacket subjected to pure axial load and combined axial load-bending moment uncoupled from shear is investigated. The test outcomes confirmed a significant improvement of the structural performance for the strengthened columns, especially for higher values of eccentricity. Finally, a standard-based practice-oriented analytical tool for designing retrofit interventions using the HPFRC jacket is proposed. The comparison between the calculated and experimental results revealed a satisfactory prediction capability

Experimental study on the in-plane response of adobe masonry wallets strengthened with textile reinforced matrix systems

Seismic strengthening of existing adobe masonry (AM) buildings has been recognized as a critical issue due to the dramatic consequences of recent seismic events occurred especially in developing countries, where a great part of the population lives in those constructions. Previous studies investigated the effectiveness of different retrofitting techniques by means of experimental programs consisting of either dynamic or static tests on reduced- or full-scale specimens, representing partial or complete AM dwellings. In this study, the output of diagonal compression tests on adobe masonry panels before and after external strengthening are presented. Three series of specimens were tested, namely, unreinforced and strengthened wallets with textile reinforced matrix (TRM) systems made of either hemp or glass meshes. Those tests benefitted from the characterization of the mud mortar that was used for both masonry joints and matrix, representing typical characteristics of existing Italian AM buildings. Main testing outcomes obtained for the AM wallets, particularly in terms of observed damage and response curves, are presented and discussed. In the end, the effectiveness of the applied TRM systems in the improvement of shear strength and ductility capacity is assessed

Experimental in-plane lateral response of a full-scale adobe masonry wall with opening

A large amount of world population lives nowadays in earthen buildings, often constructed only based on construction practice and within earthquake-prone regions. In the recent history, several strong earthquakes had dramatic consequences on these structures, highlighting their significant seismic vulnerability due to multiple reasons, such as poor mechanical properties, poor detailing, and large inertia mass. Several aspects of seismic performance of existing earthen constructions need to be investigated through full-scale experimental testing. In this regard, the present study aims at contributing to the investigation by testing a full-scale adobe masonry wall with a central door-type opening under in-plane lateral loading with cyclic fashion. The mechanical behaviour of materials, specimen's design, loading protocol and instrumentation setup are described. The experimental response curves, observed damage evolution and failure mode are discussed, especially focusing on dissipation capacity of the wall

ORAl iMmunosuppressive therapy to prevent in-Stent rEstenosiS (RAMSES) cooperation: a patient-level meta-analysis of randomized trials

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The practices of apartheid as a war crime: a critical analysis

The human suffering caused by the political ideology of apartheid in South Africa during the Apartheid era (1948-1994) prompted worldwide condemnation and a variety of diplomatic and legal responses. Amongst these responses was the attempt to have apartheid recognised both as a crime against humanity in the 1973 Apartheid Convention as well as a war crime in Article 85(4)(c) of Additional Protocol I. This article examines the origins, nature and current status of the practices of apartheid as a war crime and its possible application to the Israeli-Palestinian conflict

Complex effective index in graphene-silicon waveguides

We report for the first time and characterize experimentally the complex optical conductivity of graphene on silicon photonic waveguides. This permits us to predict accurately the behavior of photonic integrated devices encompassing graphene layers. Exploiting a Si microring add/drop resonator, we show the effect of electrical gating of graphene on the complex effective index of the waveguide by measuring both the wavelength shift of the resonance and the change in the drop peak transmission. Due to electro-refractive effect of graphene a giant (>10 123) change in the effective index is demonstrated for the first time on Si photonics waveguides and this large effect will crucially impact performances and consumption of Si photonics devices. We confirmed the results by two independent experiments involving two different gating schemes: Si gating through the ridge waveguide, and polymer-electrolyte gating. Both the experiments demonstrate a very large phase effect in good agreement with numerical calculations. The reported results validate the Kubo model for the case of graphene-Si photonics interfaces and for propagation in this type of waveguide. This is fundamental for the next design and fabrication of future graphene-silicon photonics devices

Portal venous gas after a failed endoscopic retrograde cholangiopancreatography attempt in a patient with a large hepatocellular carcinoma: A case report

The cause of hepatic portal vein gas (HPVG) is variable. Good knowledge of the possible causes, combined with the clinical assessment of the patient and a good quality imaging, is required to correctly identify the underlying cause of HPVG and to best predict the prognosis

Capacitive actuation and switching of add\u2013drop graphene-silicon micro-ring filters

We propose and experimentally demonstrate capacitive actuation of a graphene\u2013silicon micro-ring add/drop filter. The mechanism is based on a silicon\u2013SiO2\u2013graphene capacitor on top of the ring waveguide. We show the capacitive actuation of the add/drop functionality by a voltage-driven change of the graphene optical absorption. The proposed capacitive solution overcomes the need for continuous heating to keep tuned the filter\u2019s in/out resonance and therefore eliminates \u201cin operation\u201d energy consumption

Adenoviral gene transfer of PLD1-D4 enhances insulin sensitivity in mice by disrupting phospholipase D1 interaction with PED/PEA-15.

Over-expression of phosphoprotein enriched in diabetes/phosphoprotein enriched in astrocytes (PED/PEA-15) causes insulin resistance by interacting with the D4 domain of phospholipase D1 (PLD1). Indeed, the disruption of this association restores insulin sensitivity in cultured cells over-expressing PED/PEA-15. Whether the displacement of PLD1 from PED/PEA-15 improves insulin sensitivity in vivo has not been explored yet. In this work we show that treatment with a recombinant adenoviral vector containing the human D4 cDNA (Ad-D4) restores normal glucose homeostasis in transgenic mice overexpressing PED/PEA-15 (Tg ped/pea-15) by improving both insulin sensitivity and secretion. In skeletal muscle of these mice, D4 over-expression inhibited PED/PEA-15-PLD1 interaction, decreased Protein Kinase C alpha activation and restored insulin induced Protein Kinase C zeta activation, leading to amelioration of insulin-dependent glucose uptake. Interestingly, Ad-D4 administration improved insulin sensitivity also in high-fat diet treated obese C57Bl/6 mice. We conclude that PED/PEA-15-PLD1 interaction may represent a novel target for interventions aiming at improving glucose tolerance