The potential therapeutic effects of creatine supplementation on body composition and muscle function in cancer

Low muscle mass in individuals with cancer has a profound impact on quality of life and independence and is associated with greater treatment toxicity and poorer prognosis. Exercise interventions are regularly being investigated as a means to ameliorate treatment-related adverse effects, and nutritional/supplementation strategies to augment adaptations to exercise are highly valuable. Creatine (Cr) is a naturally-occurring substance in the human body that plays a critical role in energy provision during muscle contraction. Given the beneficial effects of Cr supplementation on lean body mass, strength, and physical function in a variety of clinical populations, there is therapeutic potential in individuals with cancer at heightened risk for muscle loss. Here, we provide an overview of Cr physiology, summarize the evidence on the use of Cr supplementation in various aging/clinical populations, explore mechanisms of action, and provide perspectives on the potential therapeutic role of Cr in the exercise oncology setting

The role of language in mathematical development; Evidence from children with specific language impairments.

A sample (n = 48) of eight-year-olds with specific language impairments is compared with age-matched (n = 55) and language matched controls (n = 55) on a range of tasks designed to test the interdependence of language and mathematical development. Performance across tasks varies substantially in the SLI group, showing profound deficits in production of the count word sequence and basic calculation and significant deficits in understanding of the place-value principle in Hindu-Arabic notation. Only in understanding of arithmetic principles does SLI performance approximate that of age-matched-controls, indicating that principled understanding can develop even where number sequence production and other aspects of number processing are severely compromised

Number skills and knowledge in children with specific language impairment.

The number skills of groups of 7- to 9-year-old children with specific language impairment (SLI) attending mainstream or special schools were compared with an age and nonverbal reasoning matched group (age control [AC]) and with a younger group matched on oral language comprehension. The SLI groups performed below the AC group on every skill. They also showed lower working memory functioning and had received lower levels of instruction. Nonverbal reasoning, working memory functioning, language comprehension, and instruction accounted for individual variation in number skills to differing extents depending on the skill. These factors did not explain the differences between SLI and AC groups on most skill

Number development and children with Specific Language Impairment.

The aims of this chapter is to investigate whether the number skills of children with specific language impairment (SLI) differ from those of their typically developing peers, matched in nonverbal reasoning, and a group of younger typically developing children matched on language comprehension. It assesses whether small number quantification accuracy accounts for additional variation in number tasks beyond the other influences. How children develop competence with numbers and why they differ so much in their progress are important questions whether one is concerned with numeracy, the skills and knowledge for dealing with numerical information in everyday life, or mathematics, the sciences dealing with the logic of quantity, shape, and arrangement. The study of number development in children with SLI has the potential to contribute both to the understanding of the factors that influence children's progress generally and to the knowledge base for professionals working with these children. Previous work on number in children with SLI had indicated selective impairments: children with SLI showed impaired procedural skills, particularly in counting, from an early age but less impaired understanding of number, for example counting principles. An investigation of children with SLI provided ample evidence of the continuing deficit in counting and calculation

Dilute Bose gases interacting via power-law potentials

Neutral atoms interact through a van der Waals potential which asymptotically falls off as r^{-6}. In ultracold gases, this interaction can be described to a good approximation by the atom-atom scattering length. However, corrections arise that depend on the characteristic length of the van der Waals potential. We parameterize these corrections by analyzing the energies of two- and few-atom systems under external harmonic confinement, obtained by numerically and analytically solving the Schrodinger equation. We generalize our results to particles interacting through a longer-ranged potential which asymptotically falls off as r^{-4}.Comment: 7 pages, 4 figure

Helicobacter pylori and cancer among adults in Uganda

Data from Africa on infection with Helicobacter pylori (H. pylori) are sparse. Therefore, as part of an epidemiological study of cancer in Uganda, we investigated the prevalence and determinants of antibodies against H. pylori among 854 people with different cancer types and benign tumours. Patients were recruited from hospitals in Kampala, Uganda, interviewed about various demographic and lifestyle factors and tested for antibodies against H. pylori. In all patients combined, excluding those with stomach cancer (which has been associated with H. pylori infection), the prevalence of antibodies was 87% (723/833) overall, but declined with increasing age (p = 0.02) and was lower among people who were HIV seropositive compared to seronegative (p <0.001). Otherwise, there were few consistent epidemiological associations. Among those with stomach cancer, 18/21 (86%) had anti-H. pylori antibodies (odds ratio 0.8, 95% confidence intervals 0.2–2.9, p = 0.7; estimated using all other patients as controls, with adjustment for age, sex and HIV serostatus). No other cancer site or type was significantly associated with anti-H. pylori antibodies. The prevalence of H. pylori reported here is broadly in accord with results from other developing countries, although the determinants of infection and its' role in the aetiology of gastric cancer in Uganda remain unclear

Second Messengers

Second messengers are small molecules and ions that relay signals received by cell-surface receptors to effector proteins. They include a wide variety of chemical species and have diverse properties that allow them to signal within membranes (e.g., hydrophobic molecules such as lipids and lipid derivatives), within the cytosol (e.g., polar molecules such as nucleotides and ions), or between the two (e.g., gases and free radicals). Second messengers are typically present at low concentrations in resting cells and can be rapidly produced or released when cells are stimulated. The levels of second messengers are exquisitely controlled temporally and spatially, and, during signaling, enzymatic reactions or opening of ion channels ensure that they are highly amplified. These messengers then diffuse rapidly from the source and bind to target proteins to alter their properties (activity, localization, stability, etc.) to propagate signaling

Single-shot measurement of quantum optical phase

Although the canonical phase of light, which is defined as the complement of photon number, has been described theoretically by a variety of distinct approaches, there have been no methods proposed for its measurement. Indeed doubts have been expressed about whether or not it is measurable. Here we show how it is possible, at least in principle, to perform a single-shot measurement of canonical phase using beam splitters, mirrors, phase shifters and photodetectors.Comment: This paper was published in PRL in 2002 but, at the time, was not placed on the archive. It is included now to make accessing this paper easie