2,882 research outputs found

    Graphomania: Composing Subjects in Late-Victorian Gothic Fiction and Technology

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    This dissertation explores the varied phenomena of “automatic writing” in Victorian Gothic fiction, reading the genre’s fascination with the irrepressible signifying practices of the body in light of the medical, criminological and scientific discourses that underwrite the “scriptural economy” of the late nineteenth century with their own arsenal of automatic writing machines. I have titled the project Graphomania, and I consider the term a keyword of late-Victorian culture—one that names a distinctly Victorian pathology of compulsive writing, but that alludes also to the widespread epistemic hope that writing could render objectively the internal and subjective experiences of individuals. In a chapter devoted to Victorian graphomania and the three studies that follow (graphology in Jekyll and Hyde, retinal photography in The Beetle, and phonography in Dracula), the project is particularly interested in convergences and correspondences between graphical machines and human bodies. In this study, Victorian technology and Gothic literature emerge as twin registers of the divided self, joined in their shared strategy of externalizing conflicts traditionally understood as invisible processes, but also in the consequent tendency of each uncanny text to expose its ghostly remainders and excesses in the process of trying to contain them

    Smoking Is Dangerous To Your Health: Especially If You Are a Sports Advertiser

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    Metabolomics in Neonatology

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    Throughout recent decades, the incidence of preterm birth has risen worldwide, and although the majority of preterm neonates now survive infancy, many suffer from debilitating morbidities in the short term and/or increased disease risks in the long term. Traditional diagnostic biomarkers suffer from considerable confounders, limiting their use in the early identification of diseases. There is a need to develop novel biomarkers that can identify, in real time, the evolution of organ dysfunction in an early diagnostic, monitoring, and prognostic fashion. Use of “omics,” particularly metabolomics, may provide valuable information regarding functional pathways underlying different pathologies and prediction of clinical outcomes. The emerging knowledge generated by the application of metabolomics in neonatology provides new insights that can help to identify markers of early diagnosis, disease progression, response to treatment, and new therapeutic targets. In this chapter, we review the current knowledge of different metabolomics technologies in neonatal‐perinatal medicine, including biomarker discovery, defining as yet unrecognized biologic therapeutic targets, and linking of metabolomics to relevant standard indices and long‐term outcomes

    Growth and habitat requirements of juvenile flatfish at nursery grounds in Galway Bay, Ireland

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    Coastal zones are essential nursery habitats for most juvenile flatfish species. Fish stocks are highly dependent on suitable coastal habitat features for obtaining food, shelter, and rapid growth during the vulnerable juvenile life stage. Understanding the ecological habitat requirements for juvenile flatfish is important in determining their abundance and to reliably predict potential impacts of changing coastal ecosystems on fish stocks. The present study assesses the influence of habitat characteristics on the growth and abundance of juvenile dab and plaice in four nursery areas within Galway Bay, Ireland. Field sampling was carried out in summer 2008 using a beam trawl for the collection of flatfish and a van Veen grab for the collection of sediment. The distribution and abundance of the juvenile flatfish was assessed in relation to biotic (predator–prey abundance) and abiotic (sediment size, organic content, depth, temperature, and salinity) habitat features. The condition and growth of flatfish were compared in different nursery areas and a model of habitat requirements for juvenile plaice and dab was developed. Significant variability of the measured characteristics was observed between nursery areas and high-quality nursery areas for dab and plaice were identified. These results will act as the basis for mapping of essential flatfish habitats in Galway Bay

    Fluid balance as a biomarker: impact of fluid overload on outcome in critically ill patients with acute kidney injury

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    Fluid therapy is fundamental to the acute resuscitation of critically ill patients. In general, however, early and appropriate goal-directed fluid therapy contributes to a degree of fluid overload in most if not all patients. Recent data imply that a threshold may exist beyond which, after acute resuscitation, additional fluid therapy may cause harm. In patients with acute kidney injury and/or oliguria, a positive fluid balance is almost universal. Few studies have examined the impact of fluid balance on clinical outcomes in critically ill adults with acute kidney injury. Payen and coworkers, in a secondary analysis of the SOAP (Sepsis Occurrence in Acutely Ill Patients) study, now present evidence that there is an independent association between mortality and positive fluid balance in a cohort of critically ill patients with acute kidney injury. In this commentary, we discuss these findings within the context of prior literature and propose that assessment of fluid balance should be considered as a potentially valuable biomarker of critical illness

    Factors associated with humeral avulsion of glenohumeral ligament lesions in patients with anterior shoulder instability: An analysis of the MOON shoulder instability cohort

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    BACKGROUND: Humeral avulsion of the glenohumeral ligament (HAGL) lesions are an uncommon cause of anterior glenohumeral instability and may occur in isolation or combination with other pathologies. As HAGL lesions are difficult to detect via magnetic resonance imaging (MRI) and arthroscopy, they can remain unrecognized and result in continued glenohumeral instability. PURPOSE: To compare patients with anterior shoulder instability from a large multicenter cohort with and without a diagnosis of a HAGL lesion and identify preoperative physical examination findings, patient-reported outcomes, imaging findings, and surgical management trends associated with HAGL lesions. STUDY DESIGN: Cross-sectional study; Level of evidence, 3. METHODS: Patients with anterior glenohumeral instability who underwent surgical management between 2012 and 2020 at 11 orthopaedic centers were enrolled. Patients with HAGL lesions identified intraoperatively were compared with patients without HAGL lesions. Preoperative characteristics, physical examinations, imaging findings, intraoperative findings, and surgical procedures were collected. The Student RESULTS: A total of 21 HAGL lesions were identified in 915 (2.3%) patients; approximately one-third (28.6%) of all lesions were visualized intraoperatively but not identified on preoperative MRI. Baseline characteristics did not differ between study cohorts. Compared with non-HAGL patients, HAGL patients were less likely to have a Hill-Sachs lesion (54.7% vs 28.6%; CONCLUSION: Approximately one-third of HAGL lesions were missed on preoperative MRI. HAGL patients were less likely to exhibit preoperative imaging findings associated with anterior shoulder instability, such as Hill-Sachs lesions or anterior labral pathology. These patients underwent open procedures more frequently than patients without HAGL lesions
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