A Guide to Integrating Behavioral/Process Addictions into Counselor Education Programs

Changes in CACREP standards and DSM-5diagnoses reflect the need to train counselors in the screening and treatment of behavioral/process additions (BPAs). This guide presents foundational issues counselor educators and supervisors may consider when developing an addictions course inclusive of BPAs. It also highlights components of a sample syllabus for a BPA course, including student learning outcomes (SLOs), course topics, materials, and activities/assignments. Developing curricula inclusive of BPAs is a way for counselor educators to begin to advocate for comprehensive addictions curricula within existing counselor education programs, in order to improve the competency of the counselors they train

A Guide to Integrating Behavioral/Process Addictions into Counselor Education Programs

Changes in CACREP standards and DSM-5 diagnoses reflect the need to train counselors in the screening and treatment of behavioral/process additions (BPAs). This guide presents foundational issues counselor educators and supervisors may consider when developing an addictions course inclusive of BPAs. It also highlights components of a sample syllabus for a BPA course, including student learning outcomes (SLOs), course topics, materials, and activities/assignments. Developing curricula inclusive of BPAs is a way for counselor educators to begin to advocate for comprehensive addictions curricula within existing counselor education programs, in order to improve the competency of the counselors they train

Differential regulation of iron chelator-induced IL-8 synthesis via MAP kinase and NF-κB in immortalized and malignant oral keratinocytes

Abstract Background Interleukin-8 (IL-8) is a cytokine that plays an important role in tumor progression in a variety of cancer types; however, its regulation is not well understood in oral cancer cells. In the present study, we examined the expression and mechanism of IL-8 in which it is involved by treating immortalized (IHOK) and malignant human oral keratinocytes (HN12) cells with deferoxamine (DFO). Methods IL-8 production was measured by an enzyme-linked immunoabsorbent assay and reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. Electrophoretic mobility shift assays was used to determine NF-κB binding activity. Phosphorylation and degradation of the I-κB were analyized by Western blot. Results IHOK cells incubated with DFO showed increased expression of IL-8 mRNA, as well as higher release of the IL-8 protein. The up-regulation of DFO-induced IL-8 expression was higher in IHOK cells than in HN12 cells and was concentration-dependent. DFO acted additively with IL-1β to strongly up-regulate IL-8 in IHOK cells but not in HN12 cells. Accordingly, selective p38 and ERK1/2 inhibitors for both kinases abolished DFO-induced IL-8 expression in both IHOK and HN12 cells. Furthermore, DFO induced the degradation and phosphorylation of IκB, and activation of NF-κB. The IL-8 inducing effects of DFO were mediated by a nitric oxide donor (S-nitrosoglutathione), and by pyrrolidine dithiocarbamate, an inhibitor of NF-κB, as well as by wortmannin, which inhibits the phosphatidylinositol 3-kinase-dependent activation of NAD(P)H oxidase. Conclusion This results demonstrate that DFO-induced IL-8 acts via multiple signaling pathways in immortalized and malignant oral keratinocytes, and that the control of IL-8 may be an important target for immunotheraphy against human oral premalignant lesions.</p