Alien Registration- Allwood, Hanaford D. (Caribou, Aroostook County)

https://digitalmaine.com/alien_docs/25923/thumbnail.jp

Integrated health and care systems in England : can they help prevent disease?

Objectives: Over the past 12 months, there has been increasing policy rhetoric regarding the role of the NHS in preventing disease and improving population health. In particular, the NHS Long Term Plan sees integrated care systems (ICSs) and sustainability and transformation partnerships (STPs) as routes to improving disease prevention. Here, we place current NHS England integrated care plans in their historical context and review evidence on the relationship between integrated care and prevention. We ask how the NHS Long Term Plan may help prevent disease and explore the role of the 2019 ICS and STP plans in delivering this change. Methods: We reviewed the evidence underlying the relationship between integrated care and disease prevention, and analysed 2016 STP plans for content relating to disease prevention and population health. Results: The evidence of more integrated care leading to better disease prevention is weak. Although nearly all 2016 STP plans included a prevention or population health strategy, fewer than half specified how they will work with local government public health teams, and there was incomplete coverage across plans about how they would meet NHS England prevention priorities. Plans broadly focused on individual-level approaches to disease prevention, with few describing interventions addressing social determinants of health. Conclusions: For ICSs and STPs to meaningfully prevent disease and improve population health, they need to look beyond their 2016 plans and fill the gaps in the Long Term Plan on social determinants

Multimode switching induced by a transverse field planar magnetic nanowires

We report how transverse fields affect the axial field needed to "inject" domain walls from a large Permalloy (Ni80Fe20) pad into planar nanowires of width 184 nm, 303 nm, 321 nm, and 537 nm fabricated by electron beam lithography. For the narrowest wire, different switching fields are observed under the same transverse field conditions, indicating that more than one mode or state for the domain walls may exist. In contrast, in the widest wires a transverse field causes each reversal event to occur in two stages. The different response may be attributed to the magnetostatic energy differences of domain walls in wires of different widths

Magnetic domain walls : Types, processes and applications

Domain walls (DWs) in magnetic nanowires are promising candidates for a variety of applications including Boolean/unconventional logic, memories, in-memory computing as well as magnetic sensors and biomagnetic implementations. They show rich physical behaviour and are controllable using a number of methods including magnetic fields, charge and spin currents and spin-orbit torques. In this review, we detail types of domain walls in ferromagnetic nanowires and describe processes of manipulating their state. We look at the state of the art of DW applications and give our take on the their current status, technological feasibility and challenges.Comment: 32 pages, 25 figures, review pape

Observation of Magnetic Supercooling of the Transition to the Vortex State

We demonstrate that the transition from the high-field state to the vortex state in a nanomagnetic disk shows the magnetic equivalent of supercooling. This is evidence that this magnetic transition can be described in terms of a modified Landau first-order phase transition. To accomplish this we have measured the bulk magnetization of single magnetic disks using nanomechanical torsional resonator torque magnetometry. This allows observation of single vortex creation events without averaging over an array of disks or over multiple runs.Comment: 11 pages preprint, 4 figures, accepted to New Journal of Physic

Domain wall propagation in Permalloy nanowires with a thickness gradient

The domain wall nucleation and motion processes in Permalloy nanowires with a thickness gradient along the nanowire axis have been studied. Nanowires with widths, w = 250 nm to 3 um and a base thickness of t = 10 nm were fabricated by electron-beam lithography. The magnetization hysteresis loops measured on individual nanowires are compared to corresponding nanowires without a thickness gradient. The Hc vs. t/w curves of wires with and without a thickness gradient are discussed and compared to micromagnetic simulations. We find a metastability regime at values of w, where a transformation from transverse to vortex domain wall type is expected

Manipulating ultracold atoms with a reconfigurable nanomagnetic system of domain walls

The divide between the realms of atomic-scale quantum particles and lithographically-defined nanostructures is rapidly being bridged. Hybrid quantum systems comprising ultracold gas-phase atoms and substrate-bound devices already offer exciting prospects for quantum sensors, quantum information and quantum control. Ideally, such devices should be scalable, versatile and support quantum interactions with long coherence times. Fulfilling these criteria is extremely challenging as it demands a stable and tractable interface between two disparate regimes. Here we demonstrate an architecture for atomic control based on domain walls (DWs) in planar magnetic nanowires that provides a tunable atomic interaction, manifested experimentally as the reflection of ultracold atoms from a nanowire array. We exploit the magnetic reconfigurability of the nanowires to quickly and remotely tune the interaction with high reliability. This proof-of-principle study shows the practicability of more elaborate atom chips based on magnetic nanowires being used to perform atom optics on the nanometre scale.Comment: 4 pages, 4 figure

Study of diffusion weighted MRI as a predictive biomarker of response during radiotherapy for high and intermediate risk squamous cell cancer of the oropharynx: The MeRInO study

Introduction and background: A significant proportion of patients with intermediate and high risk squamous cell cancer of the oropharynx (OPSCC) continue to relapse locally despite radical chemoradiotherapy (CRT). The toxicity of the current combination of intensified dose per fraction radiotherapy and platinum based chemotherapy limits further uniform intensification. If a predictive biomarker for outcomes from CRT can be identified during treatment then individualised and adaptive treatment strategies may be employed. Methods/design: The MeRInO study is a prospective observational imaging study of patients with intermediate and high risk, locally advanced OPSCC receiving radical RT or concurrent CRT Patients undergo diffusion weighted MRI prior to treatment (MRI_1) and during the third week of RT (MRI_2). Apparent diffusion coefficient (ADC) measurements will be made on each scan for previously specified target lesions (primary and lymph nodes) and change in ADC calculated. Patients will be followed up and disease status for each target lesion noted. The primary aim of the MeRInO study is to determine the threshold change in ADC from baseline to week 3 of RT that may identify the sub-group of non-responders during treatment. Discussion: The use of DW-MRI as a predictive biomarker during RT for SCC H&N is in its infancy but studies to date have found that response to treatment may indeed be predicted by comparison of DW-MRI carried out before and during treatment. However, previous studies have included all sub-sites and biological sub-types. Establishing ADC thresholds that predict for local failure is an essential step towards using DW-MRI to improve the therapeutic ratio in treating SCC H&N. This would be done most robustly in a specific H&N sub-site and in sub-types with similar biological behaviour. The MeRInO study will help establish these thresholds in OPSCC