The nature of Garner interference: The role of uncertainty, information, and variation in the breakdown in selective attention

The popular measure of Garner Interference specifies the detriment to performance with the task-relevant attribute in the presence of a randomly varying distractor. But is irrelevant variation per se responsible for this breakdown of selective attention as the traditional account suggests? In this study we identified an overlooked alternative account – increased irrelevant information – which threatens the validity of the variation interpretation. We designed a new condition within the Garner paradigm, Roving Baseline, which allowed for dissociating the separate and combined contributions of information and variation at both macro and micro levels of analysis. A third account, increased number of stimuli or stimulus uncertainty, was also considered as well as the rival interpretations of configural processing and change detection. Our conceptual assay was complemented by a pair of dedicated experiments that included the novel Roving Baseline condition. The results of the theoretical analysis and of the experiments converged on supporting variability as the source of Garner interference. We found no evidence for an influence of information or of stimulus uncertainty. Our study thus adds further support for W. R. Garner's original intuition when designing the paradigm and the interference bearing his name

Hypervigilance for fear after basolateral amygdala damage in humans

Recent rodent research has shown that the basolateral amygdala (BLA) inhibits unconditioned, or innate, fear. It is, however, unknown whether the BLA acts in similar ways in humans. In a group of five subjects with a rare genetic syndrome, that is, Urbach–Wiethe disease (UWD), we used a combination of structural and functional neuroimaging, and established focal, bilateral BLA damage, while other amygdala sub-regions are functionally intact. We tested the translational hypothesis that these BLA-damaged UWD-subjects are hypervigilant to facial expressions of fear, which are prototypical innate threat cues in humans. Our data indeed repeatedly confirm fear hypervigilance in these UWD subjects. They show hypervigilant responses to unconsciously presented fearful faces in a modified Stroop task. They attend longer to the eyes of dynamically displayed fearful faces in an eye-tracked emotion recognition task, and in that task recognize facial fear significantly better than control subjects. These findings provide the first direct evidence in humans in support of an inhibitory function of the BLA on the brain's threat vigilance system, which has important implications for the understanding of the amygdala's role in the disorders of fear and anxiety