8 research outputs found

    ΠžΠ±Π½Π°Ρ€ΡƒΠΆΠ΅Π½ΠΈΠ΅ Ρ‚Ρ€Π°Π΅ΠΊΡ‚ΠΎΡ€ΠΈΠΉ двиТущихся прямолинСйно Π²ΠΎΠ·Π΄ΡƒΡˆΠ½Ρ‹Ρ… Ρ†Π΅Π»Π΅ΠΉ ΠΏΡ€ΠΈ Π²Ρ‚ΠΎΡ€ΠΈΡ‡Π½ΠΎΠΉ ΠΎΠ±Ρ€Π°Π±ΠΎΡ‚ΠΊΠ΅ Ρ€Π°Π΄ΠΈΠΎΠ»ΠΎΠΊΠ°Ρ†ΠΈΠΎΠ½Π½ΠΎΠΉ ΠΈΠ½Ρ„ΠΎΡ€ΠΌΠ°Ρ†ΠΈΠΈ

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    Introduction. The primary functions of secondary processing of radar information are to detect and maintain the trajectories of air targets (AT). The AT trajectory detection can be characterised by the probability of detecting trajectory and average autocapture time. When the target moves, its distance from the radar station changes, leading to a change in the signal/noise ratio and the probability of detecting AT.Aim. To assess the impact of a change in the probability of detection of a straight and evenly moving target at consecutive time intervals of radar observation upon the characteristics of trajectory detection during secondary processing of radar information.Methods and materials. The research aim was achieved using the methods of mathematical statistics, including verification of statistical hypotheses, assessment of distribution parameters and theory of perturbations by small parameters. The ratio of the distance travelled by the AT during the review period to the target range at the initial moment of its detection was chosen as a perturbation parameter.Results. Analytical expressions were established for the probability of detecting a straight-moving AT and the probability of detecting the trajectory of its movement at interval multiples during the study period. The study illustrated the probability of detecting AT moving away from radar by means of consistent radar observations with reduced signal/noise ratios and angles between the velocity vector and the AT vector radius relative to the radar. The increase in AT speed which causes the z parameter to change from 0.01 to 0.07 reduces the probability of AT detection from 0.727 to 0.52 and leads to a corresponding change in the probability of detecting the trajectory. If the observation time is reduced by one time interval, the probability of detecting the trajectory is from 0.03 to 0.04…0.07 for signal/noise 40 ratio and from 0.06 to 0.08…0.11 for signal/noise 25 ratio (with the probability of false alarm 10–4 ).Conclusion. The resulting expressions allow for the calculation of directly moving AT trajectory detection, considering changes in the probability of detecting targets in successive time intervals of radar observations.Π’Π²Π΅Π΄Π΅Π½ΠΈΠ΅. ΠžΡΠ½ΠΎΠ²Π½Ρ‹ΠΌΠΈ Π·Π°Π΄Π°Ρ‡Π°ΠΌΠΈ Π²Ρ‚ΠΎΡ€ΠΈΡ‡Π½ΠΎΠΉ ΠΎΠ±Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ Ρ€Π°Π΄ΠΈΠΎΠ»ΠΎΠΊΠ°Ρ†ΠΈΠΎΠ½Π½ΠΎΠΉ ΠΈΠ½Ρ„ΠΎΡ€ΠΌΠ°Ρ†ΠΈΠΈ ΡΠ²Π»ΡΡŽΡ‚ΡΡ ΠΎΠ±Π½Π°Ρ€ΡƒΠΆΠ΅Π½ΠΈΠ΅ ΠΈ сопровоТдСниС Ρ‚Ρ€Π°Π΅ΠΊΡ‚ΠΎΡ€ΠΈΠΉ двиТСния Π²ΠΎΠ·Π΄ΡƒΡˆΠ½Ρ‹Ρ… Ρ†Π΅Π»Π΅ΠΉ (Π’Π¦). ΠŸΡ€ΠΈ этом процСсс обнаруТСния Ρ‚Ρ€Π°Π΅ΠΊΡ‚ΠΎΡ€ΠΈΠΉ двиТСния Π’Π¦ принято Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€ΠΈΠ·ΠΎΠ²Π°Ρ‚ΡŒ вСроятностями ΠΈΡ… обнаруТСния ΠΈ срСдним Π²Ρ€Π΅ΠΌΠ΅Π½Π΅ΠΌ ΠΈΡ… Π°Π²Ρ‚ΠΎΠ·Π°Ρ…Π²Π°Ρ‚Π°. ΠŸΡ€ΠΈ Π΄Π²ΠΈΠΆΠ΅Π½ΠΈΠΈ Ρ†Π΅Π»ΠΈ Π΅Π΅ Π΄Π°Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ ΠΎΡ‚ Ρ€Π°Π΄ΠΈΠΎΠ»ΠΎΠΊΠ°Ρ†ΠΈΠΎΠ½Π½ΠΎΠΉ станции (Π Π›Π‘) измСняСтся, Ρ‡Ρ‚ΠΎ ΠΏΡ€ΠΈΠ²ΠΎΠ΄ΠΈΡ‚ ΠΊ измСнСнию ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΡ сигнал/ΡˆΡƒΠΌ ΠΈ вСроятности обнаруТСния Π’Π¦.ЦСль Ρ€Π°Π±ΠΎΡ‚Ρ‹. ΠžΡ†Π΅Π½ΠΊΠ° влияния измСнСния вСроятности обнаруТСния прямолинСйно двиТущСйся Ρ†Π΅Π»ΠΈ ΠΏΡ€ΠΈ Ρ€Π°Π΄ΠΈΠΎΠ»ΠΎΠΊΠ°Ρ†ΠΈΠΎΠ½Π½Ρ‹Ρ… Π½Π°Π±Π»ΡŽΠ΄Π΅Π½ΠΈΡΡ… Π½Π° характСристики обнаруТСния Ρ‚Ρ€Π°Π΅ΠΊΡ‚ΠΎΡ€ΠΈΠΈ Π΅Π΅ двиТСния ΠΏΡ€ΠΈ Π²Ρ‚ΠΎΡ€ΠΈΡ‡Π½ΠΎΠΉ ΠΎΠ±Ρ€Π°Π±ΠΎΡ‚ΠΊΠ΅ Ρ€Π°Π΄ΠΈΠΎΠ»ΠΎΠΊΠ°Ρ†ΠΈΠΎΠ½Π½ΠΎΠΉ ΠΈΠ½Ρ„ΠΎΡ€ΠΌΠ°Ρ†ΠΈΠΈ.ΠœΠ΅Ρ‚ΠΎΠ΄Ρ‹. Π˜ΡΠΏΠΎΠ»ΡŒΠ·ΡƒΡŽΡ‚ΡΡ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹ матСматичСской статистики: ΠΏΡ€ΠΎΠ²Π΅Ρ€ΠΊΠ° статистичСских Π³ΠΈΠΏΠΎΡ‚Π΅Π·, ΠΎΡ†Π΅Π½ΠΊΠ° ΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€ΠΎΠ² распрСдСлСний ΠΈ тСория Π²ΠΎΠ·ΠΌΡƒΡ‰Π΅Π½ΠΈΠΉ ΠΏΠΎ ΠΌΠ°Π»ΠΎΠΌΡƒ ΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€Ρƒ. Π’ качСствС Π²ΠΎΠ·ΠΌΡƒΡ‰Π°ΡŽΡ‰Π΅Π³ΠΎ ΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€Π° Π²Ρ‹Π±Ρ€Π°Π½ΠΎ ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠ΅ расстояния, ΠΏΡ€ΠΎΡ…ΠΎΠ΄ΠΈΠΌΠΎΠ³ΠΎ Π’Π¦ Π·Π° ΠΏΠ΅Ρ€ΠΈΠΎΠ΄ ΠΎΠ±Π·ΠΎΡ€Π°, ΠΊ Π΄Π°Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ Ρ†Π΅Π»ΠΈ Π² Π½Π°Ρ‡Π°Π»ΡŒΠ½Ρ‹ΠΉ ΠΌΠΎΠΌΠ΅Π½Ρ‚ Π΅Π΅ обнаруТСния.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. ΠŸΠΎΠ»ΡƒΡ‡Π΅Π½Ρ‹ аналитичСскиС выраТСния для вСроятности обнаруТСния прямолинСйно двиТущСйся Π’Π¦ ΠΈ вСроятности обнаруТСния Ρ‚Ρ€Π°Π΅ΠΊΡ‚ΠΎΡ€ΠΈΠΈ Π΅Π΅ двиТСния Π½Π° ΠΈΠ½Ρ‚Π΅Ρ€Π²Π°Π»Π°Ρ…, ΠΊΡ€Π°Ρ‚Π½Ρ‹Ρ… ΠΏΠ΅Ρ€ΠΈΠΎΠ΄Ρƒ ΠΎΠ±Π·ΠΎΡ€Π°. ΠŸΡ€ΠΎΠΈΠ»Π»ΡŽΡΡ‚Ρ€ΠΈΡ€ΠΎΠ²Π°Π½ΠΎ ΡƒΠΌΠ΅Π½ΡŒΡˆΠ΅Π½ΠΈΠ΅ вСроятности обнаруТСния Π’Π¦, ΡƒΠ΄Π°Π»ΡΡŽΡ‰Π΅ΠΉΡΡ ΠΎΡ‚ Π Π›Π‘, ΠΏΡ€ΠΈ ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½Ρ‹Ρ… Ρ€Π°Π΄ΠΈΠΎΠ»ΠΎΠΊΠ°Ρ†ΠΈΠΎΠ½Π½Ρ‹Ρ… Π½Π°Π±Π»ΡŽΠ΄Π΅Π½ΠΈΡΡ… с ΡƒΠΌΠ΅Π½ΡŒΡˆΠ΅Π½ΠΈΠ΅ΠΌ ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠΉ сигнал/ΡˆΡƒΠΌ ΠΈ ΡƒΠ³Π»Π° ΠΌΠ΅ΠΆΠ΄Ρƒ Π²Π΅ΠΊΡ‚ΠΎΡ€ΠΎΠΌ скорости ΠΈ радиусом-Π²Π΅ΠΊΡ‚ΠΎΡ€ΠΎΠΌ Π’Π¦ ΠΎΡ‚Π½ΠΎΡΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ Π Π›Π‘. Π£Π²Π΅Π»ΠΈΡ‡Π΅Π½ΠΈΠ΅ скорости Π’Π¦, Π²Ρ‹Π·Ρ‹Π²Π°ΡŽΡ‰Π΅Π΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€Π° z с 0.01 Π΄ΠΎ 0.07, ΠΏΡ€ΠΈΠ²ΠΎΠ΄ΠΈΡ‚ ΠΊ ΡƒΠΌΠ΅Π½ΡŒΡˆΠ΅Π½ΠΈΡŽ вСроятности обнаруТСния Π’Π¦ с 0.727 Π΄ΠΎ 0.52 ΠΈ ΠΊ ΡΠΎΠΎΡ‚Π²Π΅Ρ‚ΡΡ‚Π²ΡƒΡŽΡ‰Π΅ΠΌΡƒ измСнСнию вСроятности обнаруТСния Ρ‚Ρ€Π°Π΅ΠΊΡ‚ΠΎΡ€ΠΈΠΈ. ΠŸΡ€ΠΈ сокращСнии Π²Ρ€Π΅ΠΌΠ΅Π½ΠΈ наблюдСния Π½Π° ΠΎΠ΄ΠΈΠ½ Π²Ρ€Π΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΠΈΠ½Ρ‚Π΅Ρ€Π²Π°Π» ΡƒΠΌΠ΅Π½ΡŒΡˆΠ΅Π½ΠΈΠ΅ вСроятности обнаруТСния Ρ‚Ρ€Π°Π΅ΠΊΡ‚ΠΎΡ€ΠΈΠΈ составляСт ΠΎΡ‚ 0.03 Π΄ΠΎ 0.04...0.07 для ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΡ сигнал/ΡˆΡƒΠΌ 40 ΠΈ ΠΎΡ‚ 0.06 Π΄ΠΎ 0.08...0.11 для ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΡ сигнал/ΡˆΡƒΠΌ 25 (ΠΏΡ€ΠΈ вСроятности Π»ΠΎΠΆΠ½ΠΎΠΉ Ρ‚Ρ€Π΅Π²ΠΎΠ³ΠΈ 10–4 ).Π—Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅. ΠŸΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Π΅ выраТСния ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡŽΡ‚ Ρ€Π°ΡΡΡ‡ΠΈΡ‚Ρ‹Π²Π°Ρ‚ΡŒ характСристики обнаруТСния Ρ‚Ρ€Π°Π΅ΠΊΡ‚ΠΎΡ€ΠΈΠΉ Π²ΠΎΠ·Π΄ΡƒΡˆΠ½Ρ‹Ρ… Ρ†Π΅Π»Π΅ΠΉ, двиТущихся прямолинСйно, с ΡƒΡ‡Π΅Ρ‚ΠΎΠΌ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ вСроятностСй обнаруТСния Ρ†Π΅Π»Π΅ΠΉ Π² ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½Ρ‹Ρ… Π²Ρ€Π΅ΠΌΠ΅Π½Π½Ρ‹Ρ… ΠΈΠ½Ρ‚Π΅Ρ€Π²Π°Π»Π°Ρ… ΠΎΠ±Π·ΠΎΡ€Π° Ρ€Π°Π΄ΠΈΠΎΠ»ΠΎΠΊΠ°Ρ†ΠΈΠΎΠ½Π½Ρ‹Ρ… наблюдСний

    Detection of the Trajectories of Moving Rectilinearly Air Targets in the Secondary Processing of Radar Information

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    Introduction. The primary functions of secondary processing of radar information are to detect and maintain the trajectories of air targets (AT). The AT trajectory detection can be characterised by the probability of detecting trajectory and average autocapture time. When the target moves, its distance from the radar station changes, leading to a change in the signal/noise ratio and the probability of detecting AT.Aim. To assess the impact of a change in the probability of detection of a straight and evenly moving target at consecutive time intervals of radar observation upon the characteristics of trajectory detection during secondary processing of radar information.Methods and materials. The research aim was achieved using the methods of mathematical statistics, including verification of statistical hypotheses, assessment of distribution parameters and theory of perturbations by small parameters. The ratio of the distance travelled by the AT during the review period to the target range at the initial moment of its detection was chosen as a perturbation parameter.Results. Analytical expressions were established for the probability of detecting a straight-moving AT and the probability of detecting the trajectory of its movement at interval multiples during the study period. The study illustrated the probability of detecting AT moving away from radar by means of consistent radar observations with reduced signal/noise ratios and angles between the velocity vector and the AT vector radius relative to the radar. The increase in AT speed which causes the z parameter to change from 0.01 to 0.07 reduces the probability of AT detection from 0.727 to 0.52 and leads to a corresponding change in the probability of detecting the trajectory. If the observation time is reduced by one time interval, the probability of detecting the trajectory is from 0.03 to 0.04…0.07 for signal/noise 40 ratio and from 0.06 to 0.08…0.11 for signal/noise 25 ratio (with the probability of false alarm 10–4 ).Conclusion. The resulting expressions allow for the calculation of directly moving AT trajectory detection, considering changes in the probability of detecting targets in successive time intervals of radar observations

    Роль Π½ΠΈΡ€ΠΊΠΎΠ²ΠΎΡ— дисфункції Ρƒ Ρ€ΠΎΠ·Π²ΠΈΡ‚ΠΊΡƒ ΡƒΡΠΊΠ»Π°Π΄Π½Π΅Π½ΡŒ Ρ†ΠΈΡ€ΠΎΠ·Ρƒ ΠΏΠ΅Ρ‡Ρ–Π½ΠΊΠΈ

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    Renal dysfunction is defined as progressing renal failure against chronic and acute failure of a liver at insignificant or total absence of morphological changes in kidneys. Emergence of renal dysfunction at cirrhosis is an integral part of a natural course of the disease characterizing its weight. However the importance of renal dysfunction in development of complications of cirrhosis and its correction today fully are not defined.The aim of research. To estimate the role of renal dysfunction in development of complications of cirrhosis.Materials and methods. 70 patients with cirrhosis took part in the study. 34 patients were hospitalized with ascites resistant to the diuretics and 36 patients had bleeding from esophageal varices. 29 patients have died. Duration of supervision of patients was from 2-3 weeks to 1,5-2 years. All patients had numerous clinical, laboratory and instrumental researches. They included measurement of a daily diuresis, body weight, abdominal circumference. Laboratory researches included, in addition to standard, definition of a creatinine, sodium and potassium level in blood and urine, speeds of a glomerular filtration (GFR). Ultrasonic research (US) of abdominal organs with vessels of an abdominal cavity and renal arteries color duplex scan. Diameter of renal arteries, speed ofΒ  blood-groove on them and an index of resistance of arteries were estimated. Data of instrumental and laboratory researches were compared with clinical characteristics of a course of a disease and existence of complications.Β  Β Results. In 14 (39%) patients with bleeding and 28 (82%) with ascites before development of complications the negative water balance – decrease diuresis in comparison with amount of the drunk liquid was noted at the corresponding diuretic therapy that is an early clinical sign of development of renal dysfunction. At laboratory inspection in all patients before hospitalization the tendency to GFR decrease was noted. At an ultrasonic exam of renal arteries resistance index exceeded normal ranges (0,6-0,7) and was 0,95Β±0,03. In the absence of correction of renal dysfunction the unsatisfactory results of treatment consisting in frequent recurrence of bleeding and high mortality are noted.Β Conclusions. Clinical manifestation of renal dysfunction is the negative water balance; the laboratory – a tendency to speed of a glomerular filtration decrease; the tool – reduction of diameter of renal arteries, decrease in a volume blood-groove in them, increase in an index of resistance in process of transition from the disease not complicated to the complicated current that took place in 76% of patients. In 82% patients with ascites and 39% with bleeding from esophageal varices clinically significant renal dysfunction took place before development of complications. More than for 60% of patients with early recurrence of bleeding the gepatorenal syndrome was diagnosed. At all died patients hepato-renal insufficiency was noted. ИсслСдована функция ΠΏΠΎΡ‡Π΅ΠΊ Ρƒ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… с компСнсированным ΠΈ дСкомпСнсированным Ρ‚Π΅Ρ‡Π΅Π½ΠΈΠ΅ΠΌ Ρ†ΠΈΡ€Ρ€ΠΎΠ·Π° ΠΏΠ΅Ρ‡Π΅Π½ΠΈ. Π”Π°Π½Π° ΠΎΡ†Π΅Π½ΠΊΠ° Ρ€ΠΎΠ»ΠΈ ΠΏΠΎΡ‡Π΅Ρ‡Π½ΠΎΠΉ дисфункции Π² Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΠΈ ослоТнСний Ρ†ΠΈΡ€Ρ€ΠΎΠ·Π°.Дослідили Ρ„ΡƒΠ½ΠΊΡ†Ρ–ΡŽ Π½ΠΈΡ€ΠΎΠΊ Ρƒ Ρ…Π²ΠΎΡ€ΠΈΡ… Ρ–Π· компСнсованим Ρ– дСкомпСнсованим ΠΏΠ΅Ρ€Π΅Π±Ρ–Π³ΠΎΠΌ Ρ†ΠΈΡ€ΠΎΠ·Ρƒ ΠΏΠ΅Ρ‡Ρ–Π½ΠΊΠΈ. Здійснили ΠΎΡ†Ρ–Π½ΡŽΠ²Π°Π½Π½Ρ Ρ€ΠΎΠ»Ρ– Π½ΠΈΡ€ΠΊΠΎΠ²ΠΎΡ— дисфункції Ρƒ Ρ€ΠΎΠ·Π²ΠΈΡ‚ΠΊΡƒ ΡƒΡΠΊΠ»Π°Π΄Π½Π΅Π½ΡŒ Ρ†ΠΈΡ€ΠΎΠ·Ρƒ

    ΠšΠΎΡ€Π΅ΠΊΡ†Ρ–Ρ Π½ΠΈΡ€ΠΊΠΎΠ²ΠΎΡ— дисфункції Ρƒ Ρ…Π²ΠΎΡ€ΠΈΡ… Ρ–Π· дСкомпСнсованим ΠΏΠ΅Ρ€Π΅Π±Ρ–Π³ΠΎΠΌ Ρ†ΠΈΡ€ΠΎΠ·Ρƒ ΠΏΠ΅Ρ‡Ρ–Π½ΠΊΠΈ

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    Aim. Elaboration of the uniform tactical installations concerning questions of rational therapy of patients with renal dysfunction in cirrhosis and its complicationsΒ  is actual.Methods and results. Effectiveness of the treatment of 48 patients with renal dysfunction was studied. As basis therapy terlipressin (Remestip)Β  and albumin were used. It was established that treatment of renal dysfunction improves survival rate of patients and allows to extend terms of complications development.Conclusion. It testifies the influence of correction of renal dysfunction in patients with decompensative course of cirrhosis on duration and quality of their life.Β Β ΠΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Π° Π²Ρ‹Ρ€Π°Π±ΠΎΡ‚ΠΊΠ° Π΅Π΄ΠΈΠ½Ρ‹Ρ… тактичСских установок, ΠΊΠ°ΡΠ°ΡŽΡ‰ΠΈΡ…ΡΡ вопросов Ρ€Π°Ρ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠΉ Ρ‚Π΅Ρ€Π°ΠΏΠΈΠΈ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… с ΠΏΠΎΡ‡Π΅Ρ‡Π½ΠΎΠΉ дисфункциСй ΠΏΡ€ΠΈ Ρ†ΠΈΡ€Ρ€ΠΎΠ·Π΅ ΠΏΠ΅Ρ‡Π΅Π½ΠΈ ΠΈ Π΅Π³ΠΎ ослоТнСниях. Π‘ Ρ†Π΅Π»ΡŒΡŽ ΠΎΡ†Π΅Π½ΠΊΠΈ Ρ€ΠΎΠ»ΠΈ ΠΏΠΎΡ‡Π΅Ρ‡Π½ΠΎΠΉ дисфункции ΠΏΡ€ΠΈ ослоТнСниях Ρ†ΠΈΡ€Ρ€ΠΎΠ·Π° ΠΏΠ΅Ρ‡Π΅Π½ΠΈ ΠΈΠ·ΡƒΡ‡Π΅Π½Ρ‹ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ лСчСния 48 Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ…, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹ΠΌ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½Π° коррСкция ΠΏΠΎΡ‡Π΅Ρ‡Π½ΠΎΠΉ дисфункции. Π’ основС Ρ‚Π΅Ρ€Π°ΠΏΠΈΠΈ – Π½Π°Π·Π½Π°Ρ‡Π΅Π½ΠΈΠ΅ тСрлипрСссина ΠΈ Π°Π»ΡŒΠ±ΡƒΠΌΠΈΠ½Π°, ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Ρ… составила 70%. УстановлСно, Ρ‡Ρ‚ΠΎ Π»Π΅Ρ‡Π΅Π½ΠΈΠ΅ ΠΏΠΎΡ‡Π΅Ρ‡Π½ΠΎΠΉ дисфункции ΡƒΠ»ΡƒΡ‡ΡˆΠ°Π΅Ρ‚ Π²Ρ‹ΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡ‚ΡŒ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² ΠΈ позволяСт ΡƒΠ΄Π»ΠΈΠ½ΠΈΡ‚ΡŒ сроки ΠΌΠ΅ΠΆΠ΄Ρƒ Ρ€Π΅Ρ†ΠΈΠ΄ΠΈΠ²Π°ΠΌΠΈ развития ослоТнСний. Π­Ρ‚ΠΎ ΡΠ²ΠΈΠ΄Π΅Ρ‚Π΅Π»ΡŒΡΡ‚Π²ΡƒΠ΅Ρ‚ ΠΎ значимости ΠΊΠΎΡ€Ρ€Π΅ΠΊΡ†ΠΈΠΈ ΠΏΠΎΡ‡Π΅Ρ‡Π½ΠΎΠΉ дисфункции Ρƒ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… с дСкомпСнсированным Ρ‚Π΅Ρ‡Π΅Π½ΠΈΠ΅ΠΌ Ρ†ΠΈΡ€Ρ€ΠΎΠ·Π° ΠΏΠ΅Ρ‡Π΅Π½ΠΈ Π½Π° ΠΏΡ€ΠΎΠ΄ΠΎΠ»ΠΆΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ ΠΈ качСство ΠΈΡ… ΠΆΠΈΠ·Π½ΠΈ.Β ΠΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΈΠΌ Ρ” Π½Π°ΠΏΡ€Π°Ρ†ΡŽΠ²Π°Π½Π½Ρ Ρ”Π΄ΠΈΠ½ΠΈΡ… Ρ‚Π°ΠΊΡ‚ΠΈΡ‡Π½ΠΈΡ… установок, Ρ‰ΠΎ ΡΡ‚ΠΎΡΡƒΡŽΡ‚ΡŒΡΡ ΠΏΠΈΡ‚Π°Π½ΡŒ Ρ€Π°Ρ†Ρ–ΠΎΠ½Π°Π»ΡŒΠ½ΠΎΡ— Ρ‚Π΅Ρ€Π°ΠΏΡ–Ρ— Ρ…Π²ΠΎΡ€ΠΈΡ… Ρ–Π· Π½ΠΈΡ€ΠΊΠΎΠ²ΠΎΡŽ Π΄ΠΈΡΡ„ΡƒΠ½ΠΊΡ†Ρ–Ρ”ΡŽ ΠΏΡ€ΠΈ Ρ†ΠΈΡ€ΠΎΠ·Ρ– ΠΏΠ΅Ρ‡Ρ–Π½ΠΊΠΈ Ρ‚Π° ΠΉΠΎΠ³ΠΎ ускладнСннях. Π— ΠΌΠ΅Ρ‚ΠΎΡŽ ΠΎΡ†Ρ–Π½ΠΊΠΈ Ρ€ΠΎΠ»Ρ– Π½ΠΈΡ€ΠΊΠΎΠ²ΠΎΡ— дисфункції ΠΏΡ€ΠΈ ускладнСннях Ρ†ΠΈΡ€ΠΎΠ·Ρƒ ΠΏΠ΅Ρ‡Ρ–Π½ΠΊΠΈ Π²ΠΈΠ²Ρ‡ΠΈΠ»ΠΈ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΈ лікування 48 Ρ…Π²ΠΎΡ€ΠΈΡ…, яким Π΄ΠΎΠ΄Π°Ρ‚ΠΊΠΎΠ²ΠΎ Π²ΠΈΠΊΠΎΠ½Π°Π»ΠΈ ΠΊΠΎΡ€Π΅ΠΊΡ†Ρ–ΡŽ Π½ΠΈΡ€ΠΊΠΎΠ²ΠΎΡ— дисфункції. Основою Ρ‚Π΅Ρ€Π°ΠΏΡ–Ρ— Π±ΡƒΠ»ΠΎ призначСння тСрліпрСсину ΠΉ Π°Π»ΡŒΠ±ΡƒΠΌΡ–Π½Ρƒ, Ρ—Ρ… Π΅Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½Ρ–ΡΡ‚ΡŒ становила 70%. Π’ΠΈΠ·Π½Π°Ρ‡ΠΈΠ»ΠΈ, Ρ‰ΠΎ лікування Π½ΠΈΡ€ΠΊΠΎΠ²ΠΎΡ— дисфункції ΠΏΠΎΠ»Ρ–ΠΏΡˆΡƒΡ” Π²ΠΈΠΆΠΈΠ²Π°Π½Ρ–ΡΡ‚ΡŒ ΠΏΠ°Ρ†Ρ–Ρ”Π½Ρ‚Ρ–Π² Ρ– Π΄Π°Ρ” ΠΌΠΎΠΆΠ»ΠΈΠ²Ρ–ΡΡ‚ΡŒ ΠΏΠΎΠ΄ΠΎΠ²ΠΆΠΈΡ‚ΠΈ строки ΠΌΡ–ΠΆ Ρ€Π΅Ρ†ΠΈΠ΄ΠΈΠ²Π°ΠΌΠΈ Ρ€ΠΎΠ·Π²ΠΈΡ‚ΠΊΡƒ ΡƒΡΠΊΠ»Π°Π΄Π½Π΅Π½ΡŒ. Π¦Π΅ ΡΠ²Ρ–Π΄Ρ‡ΠΈΡ‚ΡŒ ΠΏΡ€ΠΎ значСння ΠΊΠΎΡ€Π΅ΠΊΡ†Ρ–Ρ— Π½ΠΈΡ€ΠΊΠΎΠ²ΠΎΡ— дисфункції Ρƒ Ρ…Π²ΠΎΡ€ΠΈΡ… Ρ–Π· дСкомпСнсованим ΠΏΠ΅Ρ€Π΅Π±Ρ–Π³ΠΎΠΌ Ρ†ΠΈΡ€ΠΎΠ·Ρƒ ΠΏΠ΅Ρ‡Ρ–Π½ΠΊΠΈ Π½Π° Ρ‚Ρ€ΠΈΠ²Π°Π»Ρ–ΡΡ‚ΡŒ Ρ– ΡΠΊΡ–ΡΡ‚ΡŒ Ρ—Ρ…Π½ΡŒΠΎΠ³ΠΎ Тиття

    Correction of renal dysfunction in patients with the decompensated course of cirrhosis

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    Aim. Elaboration of the uniform tactical installations concerning questions of rational therapy of patients with renal dysfunction in cirrhosis and its complications is actual. Methods and results. Effectiveness of the treatment of 48 patients with renal dysfunction was studied. As basis therapy terlipressin (Remestip) and albumin were used. It was established that treatment of renal dysfunction improves survival rate of patients and allows to extend terms of complications development. Conclusion. It testifies the influence of correction of renal dysfunction in patients with decompensative course of cirrhosis on duration and quality of their life

    Role of renal dysfunction in development of cirrhosis complications

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    Renal dysfunction is defined as progressing renal failure against chronic and acute failure of a liver at insignificant or total absence of morphological changes in kidneys. Emergence of renal dysfunction at cirrhosis is an integral part of a natural course of the disease characterizing its weight. However the importance of renal dysfunction in development of complications of cirrhosis and its correction today fully are not defined. The aim of research. To estimate the role of renal dysfunction in development of complications of cirrhosis. Materials and methods. 70 patients with cirrhosis took part in the study. 34 patients were hospitalized with ascites resistant to the diuretics and 36 patients had bleeding from esophageal varices. 29 patients have died. Duration of supervision of patients was from 2-3 weeks to 1,5-2 years. All patients had numerous clinical, laboratory and instrumental researches. They included measurement of a daily diuresis, body weight, abdominal circumference. Laboratory researches included, in addition to standard, definition of a creatinine, sodium and potassium level in blood and urine, speeds of a glomerular filtration (GFR). Ultrasonic research (US) of abdominal organs with vessels of an abdominal cavity and renal arteries color duplex scan. Diameter of renal arteries, speed of blood-groove on them and an index of resistance of arteries were estimated. Data of instrumental and laboratory researches were compared with clinical characteristics of a course of a disease and existence of complications. Results. In 14 (39%) patients with bleeding and 28 (82%) with ascites before development of complications the negative water balance – decrease diuresis in comparison with amount of the drunk liquid was noted at the corresponding diuretic therapy that is an early clinical sign of development of renal dysfunction. At laboratory inspection in all patients before hospitalization the tendency to GFR decrease was noted. At an ultrasonic exam of renal arteries resistance index exceeded normal ranges (0,6-0,7) and was 0,95Β±0,03. In the absence of correction of renal dysfunction the unsatisfactory results of treatment consisting in frequent recurrence of bleeding and high mortality are noted. Conclusions. Clinical manifestation of renal dysfunction is the negative water balance; the laboratory – a tendency to speed of a glomerular filtration decrease; the tool – reduction of diameter of renal arteries, decrease in a volume blood-groove in them, increase in an index of resistance in process of transition from the disease not complicated to the complicated current that took place in 76% of patients. In 82% patients with ascites and 39% with bleeding from esophageal varices clinically significant renal dysfunction took place before development of complications. More than for 60% of patients with early recurrence of bleeding the gepatorenal syndrome was diagnosed. At all died patients hepato-renal insufficiency was noted
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