Identification of a novel cell type in peripheral lymphoid organs of mice: III. Functional properties in vivo

[No abstract available

Non-Newtonian and flow pulsatility effects in simulation models of a stented intracranial aneurysm

Permission to redistribute provided by publishers.Three models of different stent designs implanted in a cerebral aneurysm, originating from the Virtual Intracranial Stenting Challenge'07, are meshed and the flow characteristics simulated using commercial computational fluid dynamics (CFD) software in order to investigate the effects of non-Newtonian viscosity and pulsatile flow. Conventional mass inflow and wall shear stress (WSS) output are used as a means of comparing the cfd simulations. In addition, a WSS distribution is presented, which clearly discriminates in favour of the stent design identified by other groups. It is concluded that non-Newtonian and pulsatile effects are important to include in order to avoid underestimating wss, to understand dynamic flow effects, and to discriminate more effectively between stent designs. © Authors 2011

Identification of a novel cell-type in peripheral lymphoid organs of mice. V. Purification of spleen dendritic cells, new surface markers, and maintenance in vitro

Steinman, R.M., Kaplan, G., Witmer, M.D., and Cohn, Z.A. Identification of a novel cell-type in peripheral lymphoid organs of mice. V. Purification of spleen dendritic cells, new surface markers, and maintenance in vitro. J. Exp. Med. 149: 1-16, 1979.https://digitalcommons.rockefeller.edu/historical-scientific-reports/1003/thumbnail.jp

Incoherency in Central American Hydroclimate Proxy Records Spanning the Last Millennium

Continued Global Warming is Expected to Result in Reduced Precipitation and a Drier Climate in Central America. Projections of Future Changes Are Highly Uncertain, However, Due to the Spatial Resolution Limitations of Models and Insufficient Observational Data Coverage Across Space and Time. Paleoclimate Proxy Data Are Therefore Critical for Understanding Regional Climate Responses during Times of Global Climate Reorganization. Here We Present Two Lake-Sediment based Records of Precipitation Variability in Guatemala Along with a Synthesis of Central American Hydroclimate Records Spanning the Last Millennium (800–2000 CE). the Synthesis Reveals that Regional Climate Changes Have Been Strikingly Heterogeneous, even over Relatively Short Distances. Our Analysis Further Suggests that Shifts in the Mean Position of the Intertropical Convergence Zone, Which Have Been Invoked by Numerous Studies to Explain Variability in Central American and Circum-Caribbean Proxy Records, Cannot Alone Explain the Observed Pattern of Hydroclimate Variability. Instead, Interactions between Several Ocean-Atmosphere Processes and their Disparate Influences Across Variable Topography Appear to Have Resulted in Complex Precipitation Responses. These Complexities Highlight the Difficulty of Reconstructing Past Precipitation Changes Across Central America and Point to the Need for Additional Paleo-Record Development and Analysis Before the Relationships between External Forcing and Hydroclimate Change Can Be Robustly Determined. Such Efforts Should Help Anchor Model-Based Predictions of Future Responses to Continued Global Warming

Identification of a novel cell type in peripheral lymphoid organs of mice: V. Purification of spleen dendritic cells, new surface markers, and maintenance in vitro*

[No abstract available

Fabrication of Gas-Filled Tungsten-Coated Glass Shells

OAK-B135 Deuterium (D{sub 2}) filled glass shells coated with a high Z element are needed for high energy density (HED) experiments by researchers at Los Alamos National Laboratory. They report here on our initial attempt to produce such shells. Glass shells made using the drop tower technique were coated with gold, palladium or tungsten, or a mixture of two of these elements. It was found that gold and palladium coatings did not stick well to the glass and resulted in poor or delaminated films. Tungsten coatings resulted in films suitable for these targets. Bouncing of shells during coating resulted in uniform tungsten coatings, but the surface of such coatings were filled with small nodules. Proper agitation of shells using a tapping technique resulted in smooth films with minimal particulate contamination. For coating rates of {approx} 0.15 {micro}m/hr coatings with {approx} 2 nm RMS surface finish could be deposited. The surface roughness of coatings at higher rates, 0.7 {micro}m/hr, was considerably worse ({approx} 100 nm RMS). The columnar structure of the coatings allowed permeation filling of the tungsten coated glass shells with deuterium at 300 C

Trends in Drug Utilization, Glycemic Control, and Rates of Severe Hypoglycemia, 2006-2013.

ObjectiveTo examine temporal trends in utilization of glucose-lowering medications, glycemic control, and rate of severe hypoglycemia among patients with type 2 diabetes (T2DM).Research design and methodsUsing claims data from 1.66 million privately insured and Medicare Advantage patients with T2DM from 2006 to 2013, we estimated the annual 1) age- and sex-standardized proportion of patients who filled each class of agents; 2) age-, sex-, race-, and region-standardized proportion with hemoglobin A1c (HbA1c) <6%, 6 to <7%, 7 to <8%, 8 to <9%, ≥9%; and 3) age- and sex-standardized rate of severe hypoglycemia among those using medications. Proportions were calculated overall and stratified by age-group (18-44, 45-64, 65-74, and ≥75 years) and number of chronic comorbidities (zero, one, and two or more).ResultsFrom 2006 to 2013, use increased for metformin (from 47.6 to 53.5%), dipeptidyl peptidase 4 inhibitors (0.5 to 14.9%), and insulin (17.1 to 23.0%) but declined for sulfonylureas (38.8 to 30.8%) and thiazolidinediones (28.5 to 5.6%; all P < 0.001). The proportion of patients with HbA1c <7% declined (from 56.4 to 54.2%; P < 0.001) and with HbA1c ≥9% increased (9.9 to 12.2%; P < 0.001). Glycemic control varied by age and was poor among 23.3% of the youngest and 6.3% of the oldest patients in 2013. The overall rate of severe hypoglycemia remained the same (1.3 per 100 person-years; P = 0.72), declined modestly among the oldest patients (from 2.9 to 2.3; P < 0.001), and remained high among those with two or more comorbidities (3.2 to 3.5; P = 0.36).ConclusionsDuring the recent 8-year period, the use of glucose-lowering drugs has changed dramatically among patients with T2DM. Overall glycemic control has not improved and remains poor among nearly a quarter of the youngest patients. The overall rate of severe hypoglycemia remains largely unchanged

Roughening of the (1+1) interfaces in two-component surface growth with an admixture of random deposition

We simulate competitive two-component growth on a one dimensional substrate of $L$ sites. One component is a Poisson-type deposition that generates Kardar-Parisi-Zhang (KPZ) correlations. The other is random deposition (RD). We derive the universal scaling function of the interface width for this model and show that the RD admixture acts as a dilatation mechanism to the fundamental time and height scales, but leaves the KPZ correlations intact. This observation is generalized to other growth models. It is shown that the flat-substrate initial condition is responsible for the existence of an early non-scaling phase in the interface evolution. The length of this initial phase is a non-universal parameter, but its presence is universal. In application to parallel and distributed computations, the important consequence of the derived scaling is the existence of the upper bound for the desynchronization in a conservative update algorithm for parallel discrete-event simulations. It is shown that such algorithms are generally scalable in a ring communication topology.Comment: 16 pages, 16 figures, 77 reference