Estimating the causal effect of a time-varying treatment on time-to-event using structural nested failure time models

In this paper we review an approach to estimating the causal effect of a time-varying treatment on time to some event of interest. This approach is designed for the situation where the treatment may have been repeatedly adapted to patient characteristics, which themselves may also be time-dependent. In this situation the effect of the treatment cannot simply be estimated by conditioning on the patient characteristics, as these may themselves be indicators of the treatment effect. This so-called time-dependent confounding is typical in observational studies. We discuss a new class of failure time models, structural nested failure time models, which can be used to estimate the causal effect of a time-varying treatment, and present methods for estimating and testing the parameters of these models

Betti number signatures of homogeneous Poisson point processes

The Betti numbers are fundamental topological quantities that describe the k-dimensional connectivity of an object: B_0 is the number of connected components and B_k effectively counts the number of k-dimensional holes. Although they are appealing natural descriptors of shape, the higher-order Betti numbers are more difficult to compute than other measures and so have not previously been studied per se in the context of stochastic geometry or statistical physics. As a mathematically tractable model, we consider the expected Betti numbers per unit volume of Poisson-centred spheres with radius alpha. We present results from simulations and derive analytic expressions for the low intensity, small radius limits of Betti numbers in one, two, and three dimensions. The algorithms and analysis depend on alpha-shapes, a construction from computational geometry that deserves to be more widely known in the physics community.Comment: Submitted to PRE. 11 pages, 10 figure

Aerodynamic characteristics at Mach numbers of 1.5, 1.8, and 2.0 of a blended wing-body configuration with and without integral canards

An exploratory, experimental, and theoretical investigation was made of a cambered, twisted, and blended wing-body concept with and without integral canard surfaces. Theoretical calculations of the static longitudinal and lateral aerodynamic characteristics of the wing-body configurations were compared with the characteristics obtained from tests of a model in the Langley Unitary Plan wind tunnel. Mach numbers of 1.5, 1.8, and 2.0 and a Reynolds number per meter of 6.56 million were used in the calculations and tests. Overall results suggest that planform selection is extremely important and that the supplemental application of new calculation techniques should provide a process for the design of supersonic wings in which spanwise distribution of upwash and leading-edge thrust might be rationally controlled and exploited

Supersonic aircraft Patent

Design of supersonic aircraft with novel fixed, swept wing planfor

Quantum projection noise limited interferometry with coherent atoms in a Ramsey type setup

Every measurement of the population in an uncorrelated ensemble of two-level systems is limited by what is known as the quantum projection noise limit. Here, we present quantum projection noise limited performance of a Ramsey type interferometer using freely propagating coherent atoms. The experimental setup is based on an electro-optic modulator in an inherently stable Sagnac interferometer, optically coupling the two interfering atomic states via a two-photon Raman transition. Going beyond the quantum projection noise limit requires the use of reduced quantum uncertainty (squeezed) states. The experiment described demonstrates atom interferometry at the fundamental noise level and allows the observation of possible squeezing effects in an atom laser, potentially leading to improved sensitivity in atom interferometers.Comment: 8 pages, 8 figures, published in Phys. Rev.

Remote Detection of Saline Intrusion in a Coastal Aquifer Using Borehole Measurements of Self-Potential

Funded by NERC CASE studentship . Grant Number: NE/I018417/1Peer reviewedPublisher PD

Statistical Mechanics of Steiner trees

The Minimum Weight Steiner Tree (MST) is an important combinatorial optimization problem over networks that has applications in a wide range of fields. Here we discuss a general technique to translate the imposed global connectivity constrain into many local ones that can be analyzed with cavity equation techniques. This approach leads to a new optimization algorithm for MST and allows to analyze the statistical mechanics properties of MST on random graphs of various types