A Mathematical Model of the Immune and Neuroendocrine Systems Mutual Regulation under the Technogenic Chemical Factors Impact

The concept of the triad regulatory metasystem, which includes the neuroendocrine and immune regulation systems, is currently generally accepted. Changes occurring in each of the regulatory systems in response to the impact of technogenic chemical factors are also well known. This paper presents mathematical models of the immune and neuroendocrine system functioning, using the interaction between these systems in response to bacterial invasion as an example, and changes in their performance under exposure to chemical factors, taking into account the stage of functional disorders in a producing organ, using the performance of the bone marrow as an example

Scientific Data Lake for High Luminosity LHC project and other data-intensive particle and astro-particle physics experiments

Indexación ScopusThe next phase of LHC Operations-High Luminosity LHC (HL-LHC), which is aimed at ten-fold increase in the luminosity of proton-proton collisions at the energy of 14 TeV, is expected to start operation in 2027-2028 and will deliver an unprecedented scientific data volume of multi-exabyte scale. This amount of data has to be stored and the corresponding storage system should ensure fast and reliable data delivery for processing by scientific groups distributed all over the world. The present LHC computing and data processing model will not be able to provide the required infrastructure growth even taking into account the expected hardware technology evolution. To address this challenge the new state-of-The-Art computing infrastructure technologies are now being developed and are presented here. The possibilities of application of the HL-LHC distributed data handling technique for other particle and astro-particle physics experiments dealing with large-scale data volumes like DUNE, LSST, Belle-II, JUNO, SKAO etc. are also discussed. © Published under licence by IOP Publishing Ltd.https://iopscience-iop-org.recursosbiblioteca.unab.cl/article/10.1088/1742-6596/1690/1/01216

Alcohol increases circulatory disease mortality in Russia: acute and chronic effects or misattribution of cause?

Background There is a consensus that the large fluctuations in mortality seen in Russia in the past two decades can be attributed to trends in alcohol consumption. However, the precise mechanisms linking alcohol to mortality from circulatory disease remain unclear. It has recently been argued that a substantial number of such deaths currently ascribed to cardiovascular disorders are misclassified cases of acute alcohol poisoning

Manageable noninfectious pathology risk factors analysis in Perm region

Research aim is presentation of methodological approaches system for noninfectious pathology risk analysis tested in Perm region. Noninfectious pathology risk analysis in Perm region includes non-cancerogenic risk quantitative assessment based on epidemiological studies, choice of effective noninfectious pathology risk reduction strategy by means of Rospotrebnadzor and primary health care. Strategy search contains noninfectious pathology preventability estimation by comparative and expert assessment resulted to health changes reserves identification; its manageability estimation by risk factors analysis, management parameters, simulation modeling, optimization goals decision, strategy and management quality assessment Estimation of Perm region Rospotrebnadzor management activity revealed that risk indicators applying and economical assessment of risk unit value allow predicting management effects and estimating its efficiency using life expectancy increase criterion.Цель работы - представление системы методических подходов к анализу риска неинфекционной патологии, апробированных в Пермском крае. Представлены основные блоки анализа риска неинфекционной патологии в Пермском крае включая количественную оценку неканцерогенного риска на основании эпидемиологических исследований, выбор эффективных стратегий снижения риска неинфекционной патологии средствами системы Роспотребнадзора и первичной медико-санитарной помощи. Алгоритм поиска таких стратегий включает оценку предотвратимости неинфекционной патологии методами сравнительных и экспертных оценок, в результате которых определяются резервы направленных изменений здоровья, ее управляемости при помощи анализа факторов риска, параметров управления, имитационного моделирования, решения оптимизационных задач, оценки стратегии и качества управления. Оценка управляющих действий Роспотребнадзора по Пермскому краю показала, что использование показателей риска и оценка стоимости единицы риска нарушений здоровья позволяет не только прогнозировать эффект управляющих действий, но и оценивать их эффективность с использованием критерия увеличения ожидаемой продолжительности жизни

Проектирование системы электроснабжения производственной базы по обслуживанию нефтяной промышленности

В выпускной работе рассматривается система электроснабжения производственной базы по обслуживанию нефтяной промышленности. Объектом исследования является прокатно-ремонтный цех производственной базы по обслуживанию нефтяной промышленности. Цель работы: Разработка системы электроснабжения производственной базы по обслуживанию нефтяной промышленности и развитие способности решать технико-экономические вопросы при проектировании систем электроснабжения. В процессе исследования проводились расчеты электрических нагрузок прокатно-ремонтного цеха и предприятия в целом, методами коэффициента расчетной активной мощности и коэффициента спроса соответственно. Произведен выбор низковольтного оборудования прокатно-ремонтного цеха и высоковольтного оборудования главной понизительной подстанции.In the graduate qualification work, the system of power supplying production base for servicing the oil industry is considered. The object of the study is a hire and repair shop of the production base for servicing the oil industry. Purpose of work: development power supplying system production base for servicing the oil industry and development of the ability to solve technical and economic issues in the design of power supplying systems. In the process of the study, calculations were made of the electrical loads of the hire and repair shop and the enterprise as a whole, using the methods of the active power factor and the demand factor, respectively. A choice of low-voltage equipment of the hire and repair shop and high-voltage equipment of the main step-down substation were made

The HIM (Health for Izhevsk Men) trial protocol

BACKGROUND: Russia is one of the very few industrialised countries in the world where life expectancy has been declining. Alcohol has been implicated as a major contributor to the rapid fluctuations observed in male life expectancy since 1985 that have been particularly marked among working-age men. One approach to reducing the alcohol problem in Russia is 'brief interventions' which seek to change views of the personal acceptability of excessive drinking and to encourage self-directed behaviour change. There is limited understanding in Russia of the salience and applicability of Motivational Interviewing (MI), a well-defined brief intervention commonly used to target alcohol-related behaviour, but MI may have important potential for success within the Russian context. METHODS/DESIGN: The study will be an individually randomised two-armed parallel group exploratory trial. The primary hypothesis is that a brief adaptation of MI will be effective in reducing self-reported hazardous drinking at 3 months. The secondary hypothesis is that it will be effective in reducing self-reported past week beverage alcohol consumption, alcohol dependence and related problems at 3 months and at 12 months. MI will also be effective at 12 months in reducing self-reported hazardous drinking, alcohol dependence and related problems, proxy reported hazardous drinking, and recent alcohol use as indicated by bio-markers. Participants are drawn from the Izhevsk Family Study II, with eligibility determined based on proxy reports of hazardous drinking in the past year. All participants undergo a health check, with MI subsequently delivered to those in the intervention arm. Signed consent is obtained from those in the intervention arm at this point. Both groups are then invited for 3 and 12 month follow ups. The control group will not receive any additional intervention. TRIAL REGISTRATION: ISRCTN82405938

Ikeda Map and Phase Conjugated Ring Resonator Chaotic Dynamics

The dynamical behavior of a laser beam confined within a ring-phase-conjugated resonator modeled with a chaos generating element based on the Ikeda map is presented. Using the matrix ray optics, explicit expressions are obtained for the elements of the 2x2 dynamical matrix, which is found in terms of the specific map parameters, state variables and resonator parameters. The phase diagrams obtained show that the so called Ikeda map beams present complex dynamics, including critical points and metastability

Federated data storage and management infrastructure

The Large Hadron Collider (LHC)’ operating at the international CERN Laboratory in Geneva, Switzerland, is leading Big Data driven scientific explorations. Experiments at the LHC explore the fundamental nature of matter and the basic forces that shape our universe. Computing models for the High Luminosity LHC era anticipate a growth of storage needs of at least orders of magnitude, it will require new approaches in data storage organization and data handling. In our project we address the fundamental problem of designing of architecture to integrate a distributed heterogeneous disk resources for LHC experiments and other data- intensive science applications and to provide access to data from heterogeneous computing facilities. We have prototyped a federated storage for Russian T1 and T2 centers located in Moscow, St.-Petersburg and Gatchina, as well as Russian / CERN federation. We have conducted extensive tests of underlying network infrastructure and storage endpoints with synthetic performance measurement tools as well as with HENP-specific workloads, including the ones running on supercomputing platform, cloud computing and Grid for ALICE and ATLAS experiments. We will present our current accomplishments with running LHC data analysis remotely and locally to demonstrate our ability to efficiently use federated data storage experiment wide within National Academic facilities for High Energy and Nuclear Physics as well as for other data-intensive science applications, such as bio-informatics