Quantization and 2π2\pi Periodicity of the Axion Action in Topological Insulators

The Lagrangian describing the bulk electromagnetic response of a three-dimensional strong topological insulator contains a topological `axion' term of the form '\theta E dot B'. It is often stated (without proof) that the corresponding action is quantized on periodic space-time and therefore invariant under '\theta -> \theta +2\pi'. Here we provide a simple, physically motivated proof of the axion action quantization on the periodic space-time, assuming only that the vector potential is consistent with single-valuedness of the electron wavefunctions in the underlying insulator.Comment: 4 pages, 1 figure, version2 (section on axion action quantization of non-periodic systems added

Finite-temperature Screening and the Specific Heat of Doped Graphene Sheets

At low energies, electrons in doped graphene sheets are described by a massless Dirac fermion Hamiltonian. In this work we present a semi-analytical expression for the dynamical density-density linear-response function of noninteracting massless Dirac fermions (the so-called "Lindhard" function) at finite temperature. This result is crucial to describe finite-temperature screening of interacting massless Dirac fermions within the Random Phase Approximation. In particular, we use it to make quantitative predictions for the specific heat and the compressibility of doped graphene sheets. We find that, at low temperatures, the specific heat has the usual normal-Fermi-liquid linear-in-temperature behavior, with a slope that is solely controlled by the renormalized quasiparticle velocity.Comment: 9 pages, 5 figures, Submitted to J. Phys.

Effect of Telithromycin (HMR 3647) on Polymorphonuclear Neutrophil Killing of Staphylococcus aureus in Comparison with Roxithromycin

HMR 3647 (telithromycin), a new ketolide, is active on intracellular pathogens. It was previously demonstrated that it inhibits superoxide anion production in a time- and concentration-dependent manner, at concentrations which inhibit 50% of the control response of about 55 μg/ml (5 min) to 30 μg/ml (30 min); these values are similar to those obtained with roxithromycin, a classical erythromycin A derivative. Here we investigated whether these drugs modified the bactericidal activity of human polymorphonuclear neutrophils (PMN) on four strains of Staphylococcus aureus with different profiles of susceptibility to macrolides and ketolides. We found that the main factor involved in killing was the antibacterial potency of the drugs, although combinations of antibiotics with PMN were slightly more active than each component used alone against two of the four strains. In addition, high concentrations of the drugs, which impaired the PMN oxidative burst, did not impair PMN bactericidal activity. Likewise, some cytokines which enhance PMN oxidative metabolism did not modify PMN bactericidal activity in the presence or absence of macrolides or ketolides. These data suggest that oxygen-independent mechanisms contribute to the bactericidal activity of PMN on these strains of S. aureus. Both live and/or heat-killed bacteria impaired the uptake of telithromycin and roxithromycin (but not that of levofloxacin, a quinolone) in a concentration-dependent manner, owing to a modulation of PMN transductional systems involved in the activation of the macrolide carrier