Orthorhombically Mixed s and dx2−y2_{x^2-y^2} Wave Superconductivity and Josephson Tunneling

The effect of orthorhombicity on Josephson tunneling in high T$_c$ superconductors such as YBCO is studied for both single crystals and highly twinned crystals. It is shown that experiments on highly twinned crystals experimentally determine the symmetry of the superconducting twin boundaries (which can be either even or odd with respect to a reflection in the twinning plane). Conversely, Josephson experiments on highly twinned crystals can not experimentally determine whether the superconductivity is predominantly $s$-wave or predominantly $d$-wave. The direct experimental determination of the order-parameter symmetry by Josephson tunneling in YBCO thus comes from the relatively few experiments which have been carried out on untwinned single crystals.Comment: 5 pages, RevTeX file, 1 figure available on request ([email protected]

"Chain scenario" for Josephson tunneling with pi-shift in YBa2Cu3O7

We point out that all current Josephson-junction experiments probing directly the symmetry of the superconducting state in YBa2Cu3O7, can be interpreted in terms of the bilayer antiferromagnetic spin fluctuation model, which renders the superconducting state with the order parameters of extended $s$ symmetry, but with the opposite signs in the bonding and antibonding Cu-O plane bands. The essential part of our interpretation includes the Cu-O chain band which would have the order parameter of the same sign as antibonding plane band. We show that in this case net Josephson currents along and perpendicular to the chains have the phase shift equal to pi.Comment: 4 pages, revtex, 1 figure uuencoded (POSTSCRIPT figure replaced - the previous file did not print Greek letters correctly

The Ultimate Fate of Supercooled Liquids

In recent years it has become widely accepted that a dynamical length scale {\xi}_{\alpha} plays an important role in supercooled liquids near the glass transition. We examine the implications of the interplay between the growing {\xi}_{\alpha} and the size of the crystal nucleus, {\xi}_M, which shrinks on cooling. We argue that at low temperatures where {\xi}_{\alpha} > {\xi}_M a new crystallization mechanism emerges enabling rapid development of a large scale web of sparsely connected crystallinity. Though we predict this web percolates the system at too low a temperature to be easily seen in the laboratory, there are noticeable residual effects near the glass transition that can account for several previously observed unexplained phenomena of deeply supercooled liquids including Fischer clusters, and anomalous crystal growth near T_g

Gap Renormalization in Dirty Anisotropic Superconductors: Implications for the Order Parameter of the Cuprates

We contrast the effects of non-magnetic impurities on the properties of superconductors having a \dw\ order parameter, and a highly anisotropic s-wave (ASW) gap with the same nodal structure. The non-vanishing, impurity induced, off-diagonal self-energy in the ASW state is shown to gap out the low energy excitations present in the clean system, leading to a qualitatively different impurity response of the single particle density of states compared to the \dw\ state. We discuss how this behaviour can be employed to distinguish one state from the other by an analysis of high-resolution angle-resolved photoemission spectra.Comment: 12 pages, uuencoded Postscrip

Josephson tunneling in high-TcT_c superconductors

This article describes the Josephson tunneling from time-reversal symmetry-breaking states and compares it with that from time-reversal invariant states for both twinned and untwinned crystals and for both $c$-axis and basal-plane currents, in a model for orthorhombic YBCO. A macroscopic invariance group describing the superconducting state of a twinned crystal is introduced and shown to provide a useful framework for the discussion of the results for twinned crystals. In addition, a ring geometry, which allows $s$-wave and $d_{x^2-y^2}$-wave superconductivity in a tetragonal superconductor to be distinguished on the basis of symmetry arguments only, is proposed and analyzed. Finally, an appendix gives details of the experimental Josephson tunneling evidence for a superconducting state of orthorhombic $ux^2+vy^2$ symmetry in YBCO.Comment: Latex File, 18 pages, 6 Postscript figures, submitted to Phys. Rev.

Orthorhombicity mixing of s- and d- gap components in YBa2Cu3O7YBa_2Cu_3O_7 without involving the chains

Momentum decoupling develops when forward scattering dominates the pairing interaction and implies tendency for decorrelation between the physical behavior in the various regions of the Fermi surface. In this regime it is possible to obtain anisotropic s- or d-wave superconductivity even with isotropic pairing scattering. We show that in the momentum decoupling regime the distortion of the $CuO_2$ planes is enough to explain the experimental reports for s- mixing in the dominantly d-wave gap of $YBa_2Cu_3O_7$. In the case of spin fluctuations mediated pairing instead, a large part of the condensate must be located in the chains in order to understand the experiments.Comment: LATEX file and 3 Postscript figure

d-wave superconductivity near charge instabilities

We investigate the symmetry of the superconducting order parameter in the proximity of a phase-separation or of an incommensurate charge-density-wave instability. The attractive effective interaction at small or intermediate transferred momenta is singular near the instability. This strongly $q$-dependent interaction, together with a residual local repulsion between the quasiparticles and an enhanced density of states for band structures appropriate for the high temperature superconducting oxides, strongly favors the formation of $d$-wave superconductivity. The relative stability with respect to superconductivity in the $s$-wave channel is discussed in detail, finding this latter hardly realized in the above conditions. The superconducting temperature is mostly determined by the closeness to the quantum critical point associated to the charge instability and displays a stronger dependence on doping with respect to the simple proximity to a Van Hove singularity. The relevance of this scenario and the generic agreement of the resulting phase diagram with the properties displayed by high temperature superconducting oxides is discussed.Comment: 1 revtex file and 12 postscript figure

Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment.

The currently available techniques for the safety evaluation of candidate drugs are usually cost-intensive and time-consuming and are often insufficient to predict human relevant cardiotoxicity. The purpose of this study was to develop an in vitro repeated exposure toxicity methodology allowing the identification of predictive genomics biomarkers of functional relevance for drug-induced cardiotoxicity in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). The hiPSC-CMs were incubated with 156 nM doxorubicin, which is a well-characterized cardiotoxicant, for 2 or 6 days followed by washout of the test compound and further incubation in compound-free culture medium until day 14 after the onset of exposure. An xCELLigence Real-Time Cell Analyser was used to monitor doxorubicin-induced cytotoxicity while also monitoring functional alterations of cardiomyocytes by counting of the beating frequency of cardiomyocytes. Unlike single exposure, repeated doxorubicin exposure resulted in long-term arrhythmic beating in hiPSC-CMs accompanied by significant cytotoxicity. Global gene expression changes were studied using microarrays and bioinformatics tools. Analysis of the transcriptomic data revealed early expression signatures of genes involved in formation of sarcomeric structures, regulation of ion homeostasis and induction of apoptosis. Eighty-four significantly deregulated genes related to cardiac functions, stress and apoptosis were validated using real-time PCR. The expression of the 84 genes was further studied by real-time PCR in hiPSC-CMs incubated with daunorubicin and mitoxantrone, further anthracycline family members that are also known to induce cardiotoxicity. A panel of 35 genes was deregulated by all three anthracycline family members and can therefore be expected to predict the cardiotoxicity of compounds acting by similar mechanisms as doxorubicin, daunorubicin or mitoxantrone. The identified gene panel can be applied in the safety assessment of novel drug candidates as well as available therapeutics to identify compounds that may cause cardiotoxicity

Degraded Document Image Binarization Using Segmentation Algorithm

Degraded document image binarization is very difficult process due to different types of degradation over the document. Multiple algorithms as well as methods are available to get clear image of degraded document image. Many researchers have worked in this field of image processing. Still there is scope to get more clear and upgraded document image. Image segmentation is very famous process in the image processing domain. Image segmentation can used to binarize degraded document image. Binarization is a process to generate binary image from gray scale image. Also it is tedious to differentiate foreground and background pixel due to degradation. In this paper, Image Segmentation using thresholding is proposed for degraded document image binarization. Image segmentation gives better result than canny edge approach. DOI: 10.17762/ijritcc2321-8169.150611

An Efficient Technique to Secure Data Access for Multiple Domains using Overlapping Slicing

Data Mining is the process of analysing data from different perspective, summarizing it into useful information and extracts the needed information from the database. Most enterprises are collecting and storing data in large database. Database privacy is a important responsibility of organizations for to protects clients sensitive information, because their clients trust them to do so. Various anonymization techniques have been proposed for the privacy of sensitive microdata. However, there is considered between the level of privacy and the usefulness of the published data. Recently, slicing was proposed as a technique for anonymized published dataset by partitioning the dataset vertically and horizontally. This paper proposes a technique to increase the utility and privacy of a sliced dataset by allowing overlapped slicing while maintaining the prevention of membership disclosure. Also provide secure data access for multiple domains. This novel approaches work on overlapped slicing to improve preserve data utility and privacy better than traditional slicing. DOI: 10.17762/ijritcc2321-8169.16045