25 research outputs found
Intracellular Action of Mineralocorticoids: The Role of the Flavin Coenzymes and Riboflavin Analogs in Hypertension
Effect of Aldosterone on Acetylation of Ribosomal Proteins in Outer and Inner Zones of Kidney
Aldosterone-Induced Alterations in the Synthesis of Renal Cortical Chromatin Components and Acetylation of Histones
Differential Synthesis of Ribonucleic Acid in Uterine Nuclei: Evidence for Selective Gene Transcription Induced by Estrogens
Utilization of ammonium ions for purine precursor synthesis in soluble extracts of ehrlich ascites cells.
Utilization of ammonium ions for purine precursor synthesis in soluble extracts of Ehrlich ascites cells
In extracts of Ehrlich ascites cells the synthesis of α-N-formylglycinamide ribonucleotide (FGAR), an early intermediate in de novo purine synthesis, is enhanced by the presence of ammonium ions. Under these experimental conditions glutamine participation in FGAR formation is not obligatory. Ribonucleotides, deoxyribonucleotides, and purine analogues which inhibit glutamine-dependent FGAR synthesis also inhibit ammonium-ion-dependent FGAR synthesis. 3′-Ribonucleotides do not inhibit purine precursor formation from ammonium ions or from glutamine. </jats:p
