Massive Dualities in Six Dimensions

We study compactifications of string theory and M-theory to six dimensions with background fluxes. The nonzero fluxes lead to additional mass parameters. We derive the S- and T-duality rules for the corresponding (massive) supergravity theories. Specifically, we investigate the massive T-duality between Type IIA superstring theory compactified on K3 with background fluxes and Type IIB superstring theory compactified on K3. Furthermore, we generalise to the massive case the 6D 'string-string' S-duality between M-theory on K3 x S^1 and the Heterotic String on T^4. Whereas in the case of massive T--duality the mass parameters are in the fundamental representation of the U-duality group O(4,20) we find that in the case of massive S-duality they are in the 3-index antisymmetric representation. In the latter case the mass parameters involved extend those of Kaloper and Myers. We apply our duality rules to massive brane solutions, like the domain wall solutions corresponding to the mass parameters and find new massive brane solutions. Finally, we discuss the higher-dimensional interpretation of the dualities and brane solutions.Comment: 28 page

An action principle for Vasiliev's four-dimensional higher-spin gravity

We provide Vasiliev's fully nonlinear equations of motion for bosonic gauge fields in four spacetime dimensions with an action principle. We first extend Vasiliev's original system with differential forms in degrees higher than one. We then derive the resulting duality-extended equations of motion from a variational principle based on a generalized Hamiltonian sigma-model action. The generalized Hamiltonian contains two types of interaction freedoms: One set of functions that appears in the Q-structure of the generalized curvatures of the odd forms in the duality-extended system; and another set depending on the Lagrange multipliers, encoding a generalized Poisson structure, i.e. a set of polyvector fields of ranks two or higher in target space. We find that at least one of the two sets of interaction-freedom functions must be linear in order to ensure gauge invariance. We discuss consistent truncations to the minimal Type A and B models (with only even spins), spectral flows on-shell and provide boundary conditions on fields and gauge parameters that are compatible with the variational principle and that make the duality-extended system equivalent, on shell, to Vasiliev's original system.Comment: 37 pages. References added, corrected typo

Supersymmetric Higher Spin Theories

We revisit the higher spin extensions of the anti de Sitter algebra in four dimensions that incorporate internal symmetries and admit representations that contain fermions, classified long ago by Konstein and Vasiliev. We construct the $dS_4$, Euclidean and Kleinian version of these algebras, as well as the corresponding fully nonlinear Vasiliev type higher spin theories, in which the reality conditions we impose on the master fields play a crucial role. The ${\cal N}=2$ supersymmetric higher spin theory in $dS_4$, on which we elaborate further, is included in this class of models. A subset of Konstein-Vasiliev algebras are the higher spin extensions of the $AdS_4$ superalgebras $osp(4|{\cal N})$ for ${\cal N}=1,2,4$ mod 4 and can be realized using fermionic oscillators. We tensor the higher superalgebras of the latter kind with appropriate internal symmetry groups and show that the ${\cal N}=3$ mod 4 higher spin algebras are isomorphic to those with ${\cal N}=4$ mod 4. We describe the fully nonlinear higher spin theories based on these algebras as well, and we elaborate further on the ${\cal N}=6$ supersymmetric theory, providing two equivalent descriptions one of which exhibits manifestly its relation to the ${\cal N}=8$ supersymmetric higher spin theory.Comment: 30 pages. Contribution to J. Phys. A special volume on "Higher Spin Theories and AdS/CFT" edited by M. R. Gaberdiel and M. Vasilie

Coenzyme Q10 dose-escalation study in hemodialysis patients: safety, tolerability, and effect on oxidative stress.

BackgroundCoenzyme Q10 (CoQ10) supplementation improves mitochondrial coupling of respiration to oxidative phosphorylation, decreases superoxide production in endothelial cells, and may improve functional cardiac capacity in patients with congestive heart failure. There are no studies evaluating the safety, tolerability and efficacy of varying doses of CoQ10 in chronic hemodialysis patients, a population subject to increased oxidative stress.MethodsWe performed a dose escalation study to test the hypothesis that CoQ10 therapy is safe, well-tolerated, and improves biomarkers of oxidative stress in patients receiving hemodialysis therapy. Plasma concentrations of F2-isoprostanes and isofurans were measured to assess systemic oxidative stress and plasma CoQ10 concentrations were measured to determine dose, concentration and response relationships.ResultsFifteen of the 20 subjects completed the entire dose escalation sequence. Mean CoQ10 levels increased in a linear fashion from 704 ± 286 ng/mL at baseline to 4033 ± 1637 ng/mL, and plasma isofuran concentrations decreased from 141 ± 67.5 pg/mL at baseline to 72.2 ± 37.5 pg/mL at the completion of the study (P = 0.003 vs. baseline and P < 0.001 for the effect of dose escalation on isofurans). Plasma F2-isoprostane concentrations did not change during the study.ConclusionsCoQ10 supplementation at doses as high as 1800 mg per day was safe in all subjects and well-tolerated in most. Short-term daily CoQ10 supplementation decreased plasma isofuran concentrations in a dose dependent manner. CoQ10 supplementation may improve mitochondrial function and decrease oxidative stress in patients receiving hemodialysis.Trial registrationThis clinical trial was registered on clinicaltrials.gov [NCT00908297] on May 21, 2009

Propagating modes of non-Abelian tensor gauge field of second rank

In the recently proposed extension of the YM theory, non-Abelian tensor gauge field of the second rank is represented by a general tensor whose symmetric part describes the propagation of charged gauge boson of helicity two and its antisymmetric part - the helicity zero charged gauge boson. On the non-interacting level these polarizations are similar to the polarizations of the graviton and of the Abelian antisymmetric B field, but the interaction of these gauge bosons carrying non-commutative internal charges cannot be directly identified with the interaction of gravitons or B field. Our intention here is to illustrate this result from different perspectives which would include Bianchi identity for the corresponding field strength tensor and the analysis of the second-order partial differential equation which describes in this theory the propagation of non-Abelian tensor gauge field of the second rank.Comment: 22 pages, Latex fil

Strong obstruction of the Berends-Burgers-van Dam spin-3 vertex

In the eighties, Berends, Burgers and van Dam (BBvD) found a nonabelian cubic vertex for self-interacting massless fields of spin three in flat spacetime. However, they also found that this deformation is inconsistent at higher order for any multiplet of spin-three fields. For arbitrary symmetric gauge fields, we severely constrain the possible nonabelian deformations of the gauge algebra and, using these results, prove that the BBvD obstruction cannot be cured by any means, even by introducing fields of spin higher (or lower) than three.Comment: 19 pages, no figur

Invariant Differential Operators and Characters of the AdS_4 Algebra

The aim of this paper is to apply systematically to AdS_4 some modern tools in the representation theory of Lie algebras which are easily generalised to the supersymmetric and quantum group settings and necessary for applications to string theory and integrable models. Here we introduce the necessary representations of the AdS_4 algebra and group. We give explicitly all singular (null) vectors of the reducible AdS_4 Verma modules. These are used to obtain the AdS_4 invariant differential operators. Using this we display a new structure - a diagram involving four partially equivalent reducible representations one of which contains all finite-dimensional irreps of the AdS_4 algebra. We study in more detail the cases involving UIRs, in particular, the Di and the Rac singletons, and the massless UIRs. In the massless case we discover the structure of sets of 2s_0-1 conserved currents for each spin s_0 UIR, s_0=1,3/2,... All massless cases are contained in a one-parameter subfamily of the quartet diagrams mentioned above, the parameter being the spin s_0. Further we give the classification of the so(5,C) irreps presented in a diagramatic way which makes easy the derivation of all character formulae. The paper concludes with a speculation on the possible applications of the character formulae to integrable models.Comment: 30 pages, 4 figures, TEX-harvmac with input files: amssym.def, amssym.tex, epsf.tex; version 2 1 reference added; v3: minor corrections; v.4: minor corrections, v.5: minor corrections to conform with version in J. Phys. A: Math. Gen; v.6.: small correction and addition in subsections 4.1 & 4.

Iron Age and Anglo-Saxon genomes from East England reveal British migration history

British population history has been shaped by a series of immigrations, including the early Anglo-Saxon migrations after 400 CE. It remains an open question how these events affected the genetic composition of the current British population. Here, we present whole-genome sequences from 10 individuals excavated close to Cambridge in the East of England, ranging from the late Iron Age to the middle Anglo-Saxon period. By analysing shared rare variants with hundreds of modern samples from Britain and Europe, we estimate that on average the contemporary East English population derives 38% of its ancestry from Anglo-Saxon migrations. We gain further insight with a new method, rarecoal, which infers population history and identifies fine-scale genetic ancestry from rare variants. Using rarecoal we find that the Anglo-Saxon samples are closely related to modern Dutch and Danish populations, while the Iron Age samples share ancestors with multiple Northern European populations including Britain