Evaporation of a black hole off of a tense brane

We calculate the gray-body factors for scalar, vector and graviton fields in the background of an exact black hole localized on a tensional 3-brane in a world with two large extra dimensions. Finite brane tension modifies the standard results for the case with of a black hole on a brane with negligible tension. For a black hole of a fixed mass, the power carried away into the bulk diminishes as the tension increases, because the effective Planck constant, and therefore entropy of a fixed mass black hole, increase. In this limit, the semiclassical description of black hole decay becomes more reliable.Comment: a few typos corrected, accepted for publication in PR

Murine brain endothelial cells differently modulate interferon-γ and interleukin-17 production in vitro

Brain endothelial cells (BEC) are the major constituents of the blood-brain barrier (BBB), the structure that controls entrance of immune cells into CNS parenchyma. Our aim was to investigate the influence of BEC on production of IL-17 and IFN-γ-cytokines that are important for CNS inflammation. To that end, co-cultivations of the bEnd.3 brain endothelial cell line and lymph node cells (LNC) were performed, and gene expression and production of IL-17 and IFN-γ were determined. It was found that bEnd.3 cells inhibited expression and production of IFN-γ, but not of IL-17. Additionally, bEnd.3 cells also reduced production of the major IFN-γ-promoting cytokine - IL-12 - in LNC. The observed variation in modulation of pro-inflammatory cytokines by BEC could be of importance for the understanding of CNS inflammation

Theory of the Optical Conductivity in the Cuprate Superconductors

We present a study of the normal state optical conductivity in the cuprate superconductors using the nearly antiferromagnetic Fermi liquid (NAFL) description of the magnetic interaction between their planar quasiparticles. We find that the highly anisotropic scattering rate in different regions of the Brillouin zone, both as a function of frequency and temperature, a benchmark of NAFL theory, leads to an average relaxation rate of the Marginal Fermi Liquid form for overdoped and optimally doped systems, as well as for underdoped systems at high temperatures. We carry out numerical calculations of the optical conductivity for several compounds for which the input spin fluctuation parameters are known. Our results, which are in agreement with experiment on both overdoped and optimally doped systems, show that NAFL theory explains the anomalous optical behavior found in these cuprate superconductors.Comment: REVTEX file, 8 PostScript figure

Assessment of the nucleotide modifications in the high-resolution cryo-electron microscopy structure of the Escherichia coli 50S subunit.

Post-transcriptional ribosomal RNA (rRNA) modifications are present in all organisms, but their exact functional roles and positions are yet to be fully characterized. Modified nucleotides have been implicated in the stabilization of RNA structure and regulation of ribosome biogenesis and protein synthesis. In some instances, rRNA modifications can confer antibiotic resistance. High-resolution ribosome structures are thus necessary for precise determination of modified nucleotides' positions, a task that has previously been accomplished by X-ray crystallography. Here, we present a cryo-electron microscopy (cryo-EM) structure of the Escherichia coli 50S subunit at an average resolution of 2.2 Å as an additional approach for mapping modification sites. Our structure confirms known modifications present in 23S rRNA and additionally allows for localization of Mg2+ ions and their coordinated water molecules. Using our cryo-EM structure as a testbed, we developed a program for assessment of cryo-EM map quality. This program can be easily used on any RNA-containing cryo-EM structure, and an associated Coot plugin allows for visualization of validated modifications, making it highly accessible

Weak Pseudogap Behavior in the Underdoped Cuprate Superconductors

We report on an exact solution of the nearly antiferromagnetic Fermi liquid spin fermion model in the limit \pi T << \omega_{sf}, which demonstrates that the broad high energy features found in ARPES measurements of the spectral density of the underdoped cuprate superconductors are determined by strong antiferromagnetic (AF) correlations and precursor effects of an SDW state. We show that the onset temperature, T^{cr}, of weak pseudo-gap (pseudoscaling) behavior is determined by the strength, \xi, of the AF correlations, and obtain the generic changes in low frequency magnetic behavior seen in NMR experiments with \xi(T^{cr}) \approx 2, confirming the Barzykin and Pines crossover criterion.Comment: REVTEX, 4 pages, 3 EPS figure

Interaction of a brane with a moving bulk black hole

We study the interaction of an n-dimensional topological defect (n-brane) described by the Nambu-Goto action with a higher-dimensional Schwarzschild black hole moving in the bulk spacetime. We derive the general form of the perturbation equations for an n-brane in the weak field approximation and solve them analytically in the most interesting cases. We specially analyze applications to brane world models. We calculate the induced geometry on the brane generated by a moving black hole. From the point of view of a brane observer, this geometry can be obtained by solving (n+1)-dimensional Einstein's equations with a non-vanishing right hand side. We calculate the effective stress-energy tensor corresponding to this `shadow-matter'. We explicitly show that there exist regions on the brane where a brane observer sees an apparent violation of energy conditions. We also study the deflection of light propagating in the region of influence of this `shadow matter'.Comment: version accepted for publication in Phys. Rev.

Microscopic theory of weak pseudogap behavior in the underdoped cuprate superconductors I: General theory and quasiparticle properties

We derive in detail a novel solution of the spin fermion model which is valid in the quasi-static limit pi T<<omega_sf, found in the intermediate (pseudoscaling) regime of the magnetic phase diagram of cuprate superconductors, and use it to obtain results for the temperature and doping dependence of the single particle spectral density, the electron-spin fluctuation vertex function, and the low frequency dynamical spin susceptibility. The resulting strong anisotropy of the spectral density and the vertex function lead to the qualitatively different behavior of_hot_ (around k=(pi,0)) and_cold_ (around k=(pi/2,pi/2)) quasiparticles seen in ARPES experiments. We find that the broad high energy features found in ARPES measurements of the spectral density of the underdoped cuprate superconductors are determined by strong antiferromagnetic (AF) correlations and incoherent precursor effects of an SDW state, with reduced renormalized effective coupling constant. The electron spin-fluctuation vertex function, i.e. the effective interaction of low energy quasiparticles and spin degrees of freedom, is found to be strongly anisotropic and enhanced for hot quasiparticles; the corresponding charge-fluctuation vertex is considerably diminished. We thus demonstrate that, once established, strong AF correlations act to reduce substantially the effective electron-phonon coupling constant in cuprate superconductors.Comment: REVTEX with EPS figures, uses multicol.sty, epsfig,sty, psfig.st

Rat duodenal motility in vitro: Prokinetic effects of DL-homocysteine thiolactone and modulation of nitric oxide mediated inhibition

Homocysteine is a significant but modifiable risk factor for vascular diseases. As gastrointestinal smooth musculature is similar to blood vessel muscles, we investigated how elevated homocysteine levels affect nitric oxide-mediated neurotransmission in the gut. There is accumulated evidence that a dysfunction of NO neurons in the myenteric plexus may cause various diseases in the gastrointestinal tract such as achalasia, diabetic gastroparesis and infantile hypertrophic pyloric stenosis. In the present study, we aimed to assess the effects of homocysteine on NO-mediated responses in vitro, and to examine the effects of DL-homocysteine thiolactone on the spontaneous motility of rat duodenum and nitrergic neurotransmission. DL-homocysteine thiolactone concentration of 10 μmol/L leads to the immediate increase in tone, amplitude and frequency of spontaneous movements in isolated rat duodenum. L-NAME (30 μmol/L) leads to an increase in basal tone, amplitude and frequency of spontaneous contractions. The relaxations induced by EFS were significantly reduced in duodenal segments incubated in DL-homocysteine thiolactone compared with the control group. EFS-induced relaxations were inhibited by L-NAME in both experimental and control groups. These results suggest that a high level of homocysteine causes an important impairment of non-adrenergic non-cholinergic innervation of the rat duodenum. [Projekat Ministarstva nauke Republike Srbije, br. 175043

Magnetoresistance of YBa2Cu3O7 in the "cold spots" model

We calculate the in-plane magnetoresistance $\Delta\rho_{xx}/\rho_{xx}$ of YBa$_2$Cu$_3$O$_7$ in a magnetic field applied perpendicular to the $CuO_2$ planes for the ``cold spots'' model. In this model, the electron relaxation time $\tau_2\propto1/T^2$ at small regions on the Fermi surface near the Brillouin zone diagonals is much longer than the relaxation time $\tau_1\propto1/T$ at the rest of the Fermi surface ($T$ is temperature). In qualitative agreement with the experiment, we find that Kohler's rule is strongly violated, but the ratio $\Delta\rho_{xx}/\rho_{xx}\tan^2\theta_H$, where $\tan\theta_H$ is the Hall angle, is approximately temperature-independent. We find the ratio is about 5.5, which is of the same order of magnitude as in the experiment.Comment: RevTeX, 4 pages, 6 figures. V.2: 2 references adde

Impurity-induced spin polarization and NMR line broadening in underdoped cuprates

We present a theory of magnetic (S=1) Ni and nonmagnetic Zn impurities in underdoped cuprates. Both types of impurities are shown to induce S=1/2 moments on Cu sites in the proximity of the impurity, a process which is intimately related to the spin gap phenomenon in cuprates. Below a characteristic Kondo temperature, the Ni spin is partially screened by the Cu moments, resulting in an effective impurity spin S=1/2. We further analyze the Ruderman-Kittel-Kasiya-Yosida-type response of planar Cu spins to a polarization of the effective impurity moments and derive expressions for the corresponding ^{17}O NMR line broadening. The peculiar aspects of recent experimental NMR data can be traced back to different spatial characteristics of Ni and Zn moments as well as to an inherent temperature dependence of local antiferromagnetic correlations.Comment: PRB B1 01June9