Impact of smoke-free legislation on perinatal and infant mortality:a national quasi-experimental study

Smoke-free legislation is associated with improved early-life outcomes; however its impact on perinatal survival is unclear. We linked individual-level data with death certificates for all registered singletons births in England (1995-2011). We used interrupted time series logistic regression analysis to study changes in key adverse perinatal events following the July 2007 national, comprehensive smoke-free legislation. We studied 52,163 stillbirths and 10,238,950 live-births. Smoke-free legislation was associated with an immediate 7.8% (95%CI 3.5-11.8; p < 0.001) reduction in stillbirth, a 3.9% (95%CI 2.6-5.1; p < 0.001) reduction in low birth weight, and a 7.6% (95%CI 3.4-11.7; p = 0.001) reduction in neonatal mortality. No significant impact on SIDS was observed. Using a counterfactual scenario, we estimated that in the first four years following smoke-free legislation, 991 stillbirths, 5,470 cases of low birth weight, and 430 neonatal deaths were prevented. In conclusion, smoke-free legislation in England was associated with clinically important reductions in severe adverse perinatal outcomes

Parameters for assessment of newborn at birth, intestinal dysbiosis and permeability, infant feeding collected at 0,1,3,6 months of age

The study included 100 mother-child pairs, in the neonatal period, 3mths, 6mths after deliveryby natural means or after cesarean section. A standardized survey was conducted in mothersquestionnaire, regarding the risk factors present that may affect the intestinal function of their children. All children were examined, and their anthropometric data werecross-referenced with birth parameters and the postnatal adaptation period. In order to assessintestinal permeability and dysbiosis parameters, concentrations ofof zonulin and LPS by immunoenzymatic method and other parameters assessing intestinal permeability

Parameters for assessment of newborn at birth, intestinal dysbiosis and permeability, infant feeding collected at 0,1,3,6 months of age

The study included 100 mother-child pairs, in the neonatal period, 3mths, 6mths after deliveryby natural means or after cesarean section. A standardized survey was conducted in mothersquestionnaire, regarding the risk factors present that may affect the intestinal function of their children. All children were examined, and their anthropometric data werecross-referenced with birth parameters and the postnatal adaptation period. In order to assessintestinal permeability and dysbiosis parameters, concentrations ofof zonulin and LPS by immunoenzymatic method and other parameters assessing intestinal permeability.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV