1,171 research outputs found
Closure of a human tissue biobank: Individual, institutional, and field expectations during cycles of promise and disappointment
Biobanks are increasingly being established to act as mediators between patient-donors and researchers. In practice, some of these will close. This paper details the experiences of one such bank. We report interviews with the bank's staff and oversight group during the period when the bank ceased biobanking activity, reconfigured as a disseminator of best practice, before then closing altogether. The paper makes three distinct contributions: (i) to provide a detailed account of the establishment, operational challenges, and eventual closure of the bank, which makes clear the rapid turnover in a cycle of promise and disappointment; (ii) to explore this in terms of a novel analytical focus upon field, institutional, and individual expectations; and (iii) to use this typology to demonstrate how, even after the bank's closure, aspects of its work were reconfigured and reused in new contexts. This provides a unique empirical analysis of the under-reported issue of biobank closure.The Cesagen journal club and an anonymous reviewe
A Low Noise Thermometer Readout for Ruthenium Oxide Resistors
The thermometer and thermal control system, for the Absolute Radiometer for
Cosmology, Astrophysics, and Diffuse Emission (ARCADE) experiment, is
described, including the design, testing, and results from the first flight of
ARCADE. The noise is equivalent to about 1 Omega or 0.15 mK in a second for the
RuO_2 resistive thermometers at 2.7 K. The average power dissipation in each
thermometer is 1 nW. The control system can take full advantage of the
thermometers to maintain stable temperatures. Systematic effects are still
under investigation, but the measured precision and accuracy are sufficient to
allow measurement of the cosmic background spectrum.
Journal-ref: Review of Scientific Instruments Vol 73 #10 (Oct 2002)Comment: 5 pages text 7 figure
Prime Focus Spectrograph for the Subaru telescope: massively multiplexed optical and near-infrared fiber spectrograph
The Prime Focus Spectrograph (PFS) is an optical/near-infrared multifiber spectrograph with 2394 science fibers distributed across a 1.3-deg diameter field of view at the Subaru 8.2-m telescope. The wide wavelength coverage from 0.38  μm to 1.26  μm, with a resolving power of 3000, simultaneously strengthens its ability to target three main survey programs: cosmology, galactic archaeology and galaxy/AGN evolution. A medium resolution mode with a resolving power of 5000 for 0.71  μm to 0.89  μm will also be available by simply exchanging dispersers. We highlight some of the technological aspects of the design. To transform the telescope focal ratio, a broad-band coated microlens is glued to each fiber tip. A higher transmission fiber is selected for the longest part of the cable system, optimizing overall throughput; a fiber with low focal ratio degradation is selected for the fiber-positioner and fiber-slit components, minimizing the effects of fiber movements and fiber bending. Fiber positioning will be performed by a positioner consisting of two stages of piezo-electric rotary motors. The positions of these motors are measured by taking an image of artificially back-illuminated fibers with the metrology camera located in the Cassegrain container; the fibers are placed in the proper location by iteratively measuring and then adjusting the positions of the motors. Target light reaches one of the four identical fast-Schmidt spectrograph modules, each with three arms. The PFS project has passed several project-wide design reviews and is now in the construction phase
Prime focus spectrograph: Subaru's future
The Prime Focus Spectrograph (PFS) of the Subaru Measurement of Images and Redshifts (SuMIRe) project has been endorsed by Japanese community as one of the main future instruments of the Subaru 8.2-meter telescope at Mauna Kea, Hawaii. This optical/near-infrared multi-fiber spectrograph targets cosmology with galaxy surveys, Galactic archaeology, and studies of galaxy/AGN evolution. Taking advantage of Subaru’s wide field of view, which is further extended with the recently completed Wide Field Corrector, PFS will enable us to carry out multi-fiber spectroscopy of 2400 targets within 1.3 degree diameter. A microlens is attached at each fiber entrance for F-ratio transformation into a larger one so that difficulties of spectrograph design are eased. Fibers are accurately placed onto target positions by positioners, each of which consists of two stages of piezo-electric rotary motors, through iterations by using back-illuminated fiber position measurements with a widefield metrology camera. Fibers then carry light to a set of four identical fast-Schmidt spectrographs with three color arms each: the wavelength ranges from 0.38 μm to 1.3 μm will be simultaneously observed with an average resolving power of 3000. Before and during the era of extremely large telescopes, PFS will provide the unique capability of obtaining spectra of 2400 cosmological/astrophysical targets simultaneously with an 8-10 meter class telescope. The PFS collaboration, led by IPMU, consists of USP/LNA in Brazil, Caltech/JPL, Princeton, and JHU in USA, LAM in France, ASIAA in Taiwan, and NAOJ/Subaru
ARCADE 2 Measurement of the Extra-Galactic Sky Temperature at 3-90 GHz
The ARCADE 2 instrument has measured the absolute temperature of the sky at
frequencies 3, 8, 10, 30, and 90 GHz, using an open-aperture cryogenic
instrument observing at balloon altitudes with no emissive windows between the
beam-forming optics and the sky. An external blackbody calibrator provides an
{\it in situ} reference. Systematic errors were greatly reduced by using
differential radiometers and cooling all critical components to physical
temperatures approximating the CMB temperature. A linear model is used to
compare the output of each radiometer to a set of thermometers on the
instrument. Small corrections are made for the residual emission from the
flight train, balloon, atmosphere, and foreground Galactic emission. The ARCADE
2 data alone show an extragalactic rise of mK at 3.3 GHz in addition
to a CMB temperature of K. Combining the ARCADE 2 data with
data from the literature shows a background power law spectrum of [K] from 22 MHz to 10 GHz ( GHz)
in addition to a CMB temperature of K.Comment: 11 pages 5 figures Submitted to Ap
The Temperature of the CMB at 10 GHz
We report the results of an effort to measure the low frequency portion of
the spectrum of the Cosmic Microwave Background Radiation (CMB), using a
balloon-borne instrument called ARCADE (Absolute Radiometer for Cosmology,
Astrophysics, and Diffuse Emission). These measurements are to search for
deviations from a thermal spectrum that are expected to exist in the CMB due to
various processes in the early universe. The radiometric temperature was
measured at 10 and 30 GHz using a cryogenic open-aperture instrument with no
emissive windows. An external blackbody calibrator provides an in situ
reference. A linear model is used to compare the radiometer output to a set of
thermometers on the instrument. The unmodeled residuals are less than 50 mK
peak-to-peak with a weighted RMS of 6 mK. Small corrections are made for the
residual emission from the flight train, atmosphere, and foreground Galactic
emission. The measured radiometric temperature of the CMB is 2.721 +/- 0.010 K
at 10 GHz and 2.694 +/- 0.032 K at 30 GHz.Comment: 8 pages including 5 figures. Submitted to The Astrophysical Journa
Resolving the Radio Source Background: Deeper Understanding Through Confusion
We used the Karl G. Jansky Very Large Array (VLA) to image one primary beam
area at 3 GHz with 8 arcsec FWHM resolution and 1.0 microJy/beam rms noise near
the pointing center. The P(D) distribution from the central 10 arcmin of this
confusion-limited image constrains the count of discrete sources in the 1 <
S(microJy/beam) < 10 range. At this level the brightness-weighted differential
count S^2 n(S) is converging rapidly, as predicted by evolutionary models in
which the faintest radio sources are star-forming galaxies; and ~96$% of the
background originating in galaxies has been resolved into discrete sources.
About 63% of the radio background is produced by AGNs, and the remaining 37%
comes from star-forming galaxies that obey the far-infrared (FIR) / radio
correlation and account for most of the FIR background at lambda = 160 microns.
Our new data confirm that radio sources powered by AGNs and star formation
evolve at about the same rate, a result consistent with AGN feedback and the
rough correlation of black hole and bulge stellar masses. The confusion at
centimeter wavelengths is low enough that neither the planned SKA nor its
pathfinder ASKAP EMU survey should be confusion limited, and the ultimate
source detection limit imposed by "natural" confusion is < 0.01 microJy at 1.4
GHz. If discrete sources dominate the bright extragalactic background reported
by ARCADE2 at 3.3 GHz, they cannot be located in or near galaxies and most are
< 0.03 microJy at 1.4 GHz.Comment: 28 pages including 16 figures. ApJ accepted for publicatio
- …